Dla naukowców
M. Lorenzi, T. Lorenzi, E. Marzetti, et al.Exp Gerontol. 2016;81:8-12 High-temperature requirement serine protease A1 (HtrA1) is a secreted multidomain serine protease implicated in the inhibition of signaling of active transforming growth factor-β (TGF-β)1, a cytokine which has an important anti-inflammation role. These findings demonstrate for the first time the association of plasma levels of HtrA1 with frailty status. |
E. García-Esquinas, B. Rahi, K. Peres, et al.Am J Clin Nutr. 2016;104(1):132-42 We sought to examine the dose-response association between fruit and vegetables consumption and the risk of frailty in older adults. Among community-dwelling older adults, fruit and vegetables consumption was associated with a lower short-term risk of frailty in a dose-response manner, and the strongest association was obtained with 3 portions of fruit/d and 2 portions of vegetables/d |
Y.R. Huo, P. Suriyaarachchi, F. Gomez, et al.Arch Gerontol Geriatr. 2016;65:255-9 The goal of this study was to obtain a comprehensive phenotype of sarcopenic obesity in this high-risk population. Authors have found that sarcopenic obese subjects were older (81.1±7.3), mostly female and more likely to have lower bone mineral density, lower grip strength, slower gait velocity, and poor balance. Sarcopenic obese individuals also showed significantly higher parathyroid hormone and lower vitamin D. |
S. Freitag and S. SchmidtSoc Sci Med. 2016;160:120-7 The aim of this study is to investigate the effects of a biographical disclosure intervention on psychological frailty and health in older adults. The results of the intervention indicate a short-term positive effect on frailty and mental health in elderly people, who benefitted from the disclosure intervention in terms of improved mental health and lower frailty levels. |
Q.L. Xue, J. Tian, L.P. Fried, et al.Am J Epidemiol. 2016;183(11):1037-44 Different phenotypes have increasingly been used as tools for clinical characterization of frailty among older adults. Although there have been studies about the comparability and effectiveness of various simplifications and approximations of existing frailty phenotypes for risk prediction, there have been no studies in which investigators evaluated the stability of the clinical characterization achieved. Findings obtained shown that it was no merely the number of criteria used to characterize the PFPs but rather the specific criteria combinations that predicted the risk of adverse outcomes. There are clinically important contexts in which simplified PFPs cannot be used interchangeably. |
F.J. Tarazona-Santabalbina, M.C. Gómez-Cabrera, P. Pérez-Ros, et al.J Am Med Dir Assoc. 2016;17(5):426-33 The aim of this study is to ascertain if a supervised-facility multicomponent exercise program (MEP) when performed by frail older persons can reverse frailty and improve functionality; cognitive, emotional, and social networking; as well as biological biomarkers of frailty, when compared with a controlled population that received no training. |



