/**
* Note: This file may contain artifacts of previous malicious infection.
* However, the dangerous code has been removed, and the file is now safe to use.
*/

/**
 * @file
 * Pathologic text filter for Drupal.
 *
 * This input filter attempts to make sure that link and image paths will
 * always be correct, even when domain names change, content is moved from one
 * server to another, the Clean URLs feature is toggled, etc.
 */

/**
 * Implements hook_filter_info().
 */
function pathologic_filter_info() {
  return array(
    'pathologic' => array(
      'title' => t('Correct URLs with Pathologic'),
      'process callback' => '_pathologic_filter',
      'settings callback' => '_pathologic_settings',
      'default settings' => array(
        'local_paths' => '',
        'protocol_style' => 'full',
      ),
      // Set weight to 50 so that it will hopefully appear at the bottom of
      // filter lists by default. 50 is the maximum value of the weight menu
      // for each row in the filter table (the menu is hidden by JavaScript to
      // use table row dragging instead when JS is enabled).
      'weight' => 50,
    )
  );
}

/**
 * Settings callback for Pathologic.
 */
function _pathologic_settings($form, &$form_state, $filter, $format, $defaults, $filters) {
  return array(
    'reminder' => array(
      '#type' => 'item',
      '#title' => t('In most cases, Pathologic should be the <em>last</em> filter in the &ldquo;Filter processing order&rdquo; list.'),
      '#weight' => -10,
    ),
    'protocol_style' => array(
      '#type' => 'radios',
      '#title' => t('Processed URL format'),
      '#default_value' => isset($filter->settings['protocol_style']) ? $filter->settings['protocol_style'] : $defaults['protocol_style'],
      '#options' => array(
        'full' => t('Full URL (<code>http://example.com/foo/bar</code>)'),
        'proto-rel' => t('Protocol relative URL (<code>//example.com/foo/bar</code>)'),
        'path' => t('Path relative to server root (<code>/foo/bar</code>)'),
      ),
      '#description' => t('The <em>Full URL</em> option is best for stopping broken images and links in syndicated content (such as in RSS feeds), but will likely lead to problems if your site is accessible by both HTTP and HTTPS. Paths output with the <em>Protocol relative URL</em> option will avoid such problems, but feed readers and other software not using up-to-date standards may be confused by the paths. The <em>Path relative to server root</em> option will avoid problems with sites accessible by both HTTP and HTTPS with no compatibility concerns, but will absolutely not fix broken images and links in syndicated content.'),
      '#weight' => 10,
    ),
    'local_paths' => array(
      '#type' => 'textarea',
      '#title' =>  t('All base paths for this site'),
      '#default_value' => isset($filter->settings['local_paths']) ? $filter->settings['local_paths'] : $defaults['local_paths'],
        '#description' => t('If this site is or was available at more than one base path or URL, enter them here, separated by line breaks. For example, if this site is live at <code>http://example.com/</code> but has a staging version at <code>http://dev.example.org/staging/</code>, you would enter both those URLs here. If confused, please read <a href="!docs">Pathologic&rsquo;s documentation</a> for more information about this option and what it affects.', array('!docs' => 'http://drupal.org/node/257026')),
      '#weight' => 20,
    ),
  );
}

/**
 * Pathologic filter callback.
 *
 * Previous versions of this module worked (or, rather, failed) under the
 * assumption that $langcode contained the language code of the node. Sadly,
 * this isn't the case.
 * @see http://drupal.org/node/1812264
 * However, it turns out that the language of the current node isn't as
 * important as the language of the node we're linking to, and even then only
 * if language path prefixing (eg /ja/node/123) is in use. REMEMBER THIS IN THE
 * FUTURE, ALBRIGHT.
 *
 * The below code uses the @ operator before parse_url() calls because in PHP
 * 5.3.2 and earlier, parse_url() causes a warning of parsing fails. The @
 * operator is usually a pretty strong indicator of code smell, but please don't
 * judge me by it in this case; ordinarily, I despise its use, but I can't find
 * a cleaner way to avoid this problem (using set_error_handler() could work,
 * but I wouldn't call that "cleaner"). Fortunately, Drupal 8 will require at
 * least PHP 5.3.5, so this mess doesn't have to spread into the D8 branch of
 * Pathologic.
 * @see https://drupal.org/node/2104849
 *
 * @todo Can we do the parsing of the local path settings somehow when the
 * settings form is submitted instead of doing it here?
 */
function _pathologic_filter($text, $filter, $format, $langcode, $cache, $cache_id) {
  // Get the base URL and explode it into component parts. We add these parts
  // to the exploded local paths settings later.
  global $base_url;
  $base_url_parts = @parse_url($base_url . '/');
  // Since we have to do some gnarly processing even before we do the *really*
  // gnarly processing, let's static save the settings - it'll speed things up
  // if, for example, we're importing many nodes, and not slow things down too
  // much if it's just a one-off. But since different input formats will have
  // different settings, we build an array of settings, keyed by format ID.
  $cached_settings = &drupal_static(__FUNCTION__, array());
  if (!isset($cached_settings[$filter->format])) {
    $filter->settings['local_paths_exploded'] = array();
    if ($filter->settings['local_paths'] !== '') {
      // Build an array of the exploded local paths for this format's settings.
      // array_filter() below is filtering out items from the array which equal
      // FALSE - so empty strings (which were causing problems.
      // @see http://drupal.org/node/1727492
      $local_paths = array_filter(array_map('trim', explode("\n", $filter->settings['local_paths'])));
      foreach ($local_paths as $local) {
        $parts = @parse_url($local);
        // Okay, what the hellish "if" statement is doing below is checking to
        // make sure we aren't about to add a path to our array of exploded
        // local paths which matches the current "local" path. We consider it
        // not a match, if…
        // @todo: This is pretty horrible. Can this be simplified?
        if (
          (
            // If this URI has a host, and…
            isset($parts['host']) &&
            (
              // Either the host is different from the current host…
              $parts['host'] !== $base_url_parts['host']
              // Or, if the hosts are the same, but the paths are different…
              // @see http://drupal.org/node/1875406
              || (
                // Noobs (like me): "xor" means "true if one or the other are
                // true, but not both."
                (isset($parts['path']) xor isset($base_url_parts['path']))
                || (isset($parts['path']) && isset($base_url_parts['path']) && $parts['path']  !== $base_url_parts['path'])
              )
            )
          ) ||
          // Or…
          (
            // The URI doesn't have a host…
            !isset($parts['host'])
          ) &&
          // And the path parts don't match (if either doesn't have a path
          // part, they can't match)…
          (
            !isset($parts['path']) ||
            !isset($base_url_parts['path']) ||
            $parts['path'] !== $base_url_parts['path']
          )
        ) {
          // Add it to the list.
          $filter->settings['local_paths_exploded'][] = $parts;
        }
      }
    }
    // Now add local paths based on "this" server URL.
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path']);
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path'], 'host' => $base_url_parts['host']);
    // We'll also just store the host part separately for easy access.
    $filter->settings['base_url_host'] = $base_url_parts['host'];

    $cached_settings[$filter->format] = $filter->settings;
  }
  // Get the language code for the text we're about to process.
  $cached_settings['langcode'] = $langcode;
  // And also take note of which settings in the settings array should apply.
  $cached_settings['current_settings'] = &$cached_settings[$filter->format];

  // Now that we have all of our settings prepared, attempt to process all
  // paths in href, src, action or longdesc HTML attributes. The pattern below
  // is not perfect, but the callback will do more checking to make sure the
  // paths it receives make sense to operate upon, and just return the original
  // paths if not.
  return preg_replace_callback('~ (href|src|action|longdesc)="([^"]+)~i', '_pathologic_replace', $text);
}

/**
 * Process and replace paths. preg_replace_callback() callback.
 */
function _pathologic_replace($matches) {
  // Get the base path.
  global $base_path;

  // Get the settings for the filter. Since we can't pass extra parameters
  // through to a callback called by preg_replace_callback(), there's basically
  // three ways to do this that I can determine: use eval() and friends; abuse
  // globals; or abuse drupal_static(). The latter is the least offensive, I
  // guess… Note that we don't do the & thing here so that we can modify
  // $cached_settings later and not have the changes be "permanent."
  $cached_settings = drupal_static('_pathologic_filter');
  // If it appears the path is a scheme-less URL, prepend a scheme to it.
  // parse_url() cannot properly parse scheme-less URLs. Don't worry; if it
  // looks like Pathologic can't handle the URL, it will return the scheme-less
  // original.
  // @see https://drupal.org/node/1617944
  // @see https://drupal.org/node/2030789
  if (strpos($matches[2], '//') === 0) {
    if (isset($_SERVER['https']) && strtolower($_SERVER['https']) === 'on') {
      $matches[2] = 'https:' . $matches[2];
    }
    else {
      $matches[2] = 'http:' . $matches[2];
    }
  }
  // Now parse the URL after reverting HTML character encoding.
  // @see http://drupal.org/node/1672932
  $original_url = htmlspecialchars_decode($matches[2]);
  // …and parse the URL
  $parts = @parse_url($original_url);
  // Do some more early tests to see if we should just give up now.
  if (
    // If parse_url() failed, give up.
    $parts === FALSE
    || (
      // If there's a scheme part and it doesn't look useful, bail out.
      isset($parts['scheme'])
      // We allow for the storage of permitted schemes in a variable, though we
      // don't actually give the user any way to edit it at this point. This
      // allows developers to set this array if they have unusual needs where
      // they don't want Pathologic to trip over a URL with an unusual scheme.
      // @see http://drupal.org/node/1834308
      // "files" and "internal" are for Path Filter compatibility.
      && !in_array($parts['scheme'], variable_get('pathologic_scheme_whitelist', array('http', 'https', 'files', 'internal')))
    )
    // Bail out if it looks like there's only a fragment part.
    || (isset($parts['fragment']) && count($parts) === 1)
  ) {
    // Give up by "replacing" the original with the same.
    return $matches[0];
  }

  if (isset($parts['path'])) {
    // Undo possible URL encoding in the path.
    // @see http://drupal.org/node/1672932
    $parts['path'] = rawurldecode($parts['path']);
  }
  else {
    $parts['path'] = '';
  }

  // Check to see if we're dealing with a file.
  // @todo Should we still try to do path correction on these files too?
  if (isset($parts['scheme']) && $parts['scheme'] === 'files') {
    // Path Filter "files:" support. What we're basically going to do here is
    // rebuild $parts from the full URL of the file.
    $new_parts = @parse_url(file_create_url(file_default_scheme() . '://' . $parts['path']));
    // If there were query parts from the original parsing, copy them over.
    if (!empty($parts['query'])) {
      $new_parts['query'] = $parts['query'];
    }
    $new_parts['path'] = rawurldecode($new_parts['path']);
    $parts = $new_parts;
    // Don't do language handling for file paths.
    $cached_settings['is_file'] = TRUE;
  }
  else {
    $cached_settings['is_file'] = FALSE;
  }

  // Let's also bail out of this doesn't look like a local path.
  $found = FALSE;
  // Cycle through local paths and find one with a host and a path that matches;
  // or just a host if that's all we have; or just a starting path if that's
  // what we have.
  foreach ($cached_settings['current_settings']['local_paths_exploded'] as $exploded) {
    // If a path is available in both…
    if (isset($exploded['path']) && isset($parts['path'])
      // And the paths match…
      && strpos($parts['path'], $exploded['path']) === 0
      // And either they have the same host, or both have no host…
      && (
        (isset($exploded['host']) && isset($parts['host']) && $exploded['host'] === $parts['host'])
        || (!isset($exploded['host']) && !isset($parts['host']))
      )
    ) {
      // Remove the shared path from the path. This is because the "Also local"
      // path was something like http://foo/bar and this URL is something like
      // http://foo/bar/baz; or the "Also local" was something like /bar and
      // this URL is something like /bar/baz. And we only care about the /baz
      // part.
      $parts['path'] = drupal_substr($parts['path'], drupal_strlen($exploded['path']));
      $found = TRUE;
      // Break out of the foreach loop
      break;
    }
    // Okay, we didn't match on path alone, or host and path together. Can we
    // match on just host? Note that for this one we are looking for paths which
    // are just hosts; not hosts with paths.
    elseif ((isset($parts['host']) && !isset($exploded['path']) && isset($exploded['host']) && $exploded['host'] === $parts['host'])) {
      // No further editing; just continue
      $found = TRUE;
      // Break out of foreach loop
      break;
    }
    // Is this is a root-relative url (no host) that didn't match above?
    // Allow a match if local path has no path,
    // but don't "break" because we'd prefer to keep checking for a local url
    // that might more fully match the beginning of our url's path
    // e.g.: if our url is /foo/bar we'll mark this as a match for
    // http://example.com but want to keep searching and would prefer a match
    // to http://example.com/foo if that's configured as a local path
    elseif (!isset($parts['host']) && (!isset($exploded['path']) || $exploded['path'] === $base_path)) {
      $found = TRUE;
    }
  }

  // If the path is not within the drupal root return original url, unchanged
  if (!$found) {
    return $matches[0];
  }

  // Okay, format the URL.
  // If there's still a slash lingering at the start of the path, chop it off.
  $parts['path'] = ltrim($parts['path'],'/');

  // Examine the query part of the URL. Break it up and look through it; if it
  // has a value for "q", we want to use that as our trimmed path, and remove it
  // from the array. If any of its values are empty strings (that will be the
  // case for "bar" if a string like "foo=3&bar&baz=4" is passed through
  // parse_str()), replace them with NULL so that url() (or, more
  // specifically, drupal_http_build_query()) can still handle it.
  if (isset($parts['query'])) {
    parse_str($parts['query'], $parts['qparts']);
    foreach ($parts['qparts'] as $key => $value) {
      if ($value === '') {
        $parts['qparts'][$key] = NULL;
      }
      elseif ($key === 'q') {
        $parts['path'] = $value;
        unset($parts['qparts']['q']);
      }
    }
  }
  else {
    $parts['qparts'] = NULL;
  }

  // If we don't have a path yet, bail out.
  if (!isset($parts['path'])) {
    return $matches[0];
  }

  // If we didn't previously identify this as a file, check to see if the file
  // exists now that we have the correct path relative to DRUPAL_ROOT
  if (!$cached_settings['is_file']) {
    $cached_settings['is_file'] = !empty($parts['path']) && is_file(DRUPAL_ROOT . '/'. $parts['path']);
  }

  // Okay, deal with language stuff.
  if ($cached_settings['is_file']) {
    // If we're linking to a file, use a fake LANGUAGE_NONE language object.
    // Otherwise, the path may get prefixed with the "current" language prefix
    // (eg, /ja/misc/message-24-ok.png)
    $parts['language_obj'] = (object) array('language' => LANGUAGE_NONE, 'prefix' => '');
  }
  else {
    // Let's see if we can split off a language prefix from the path.
    if (module_exists('locale')) {
      // Sometimes this file will be require_once-d by the locale module before
      // this point, and sometimes not. We require_once it ourselves to be sure.
      require_once DRUPAL_ROOT . '/includes/language.inc';
      list($language_obj, $path) = language_url_split_prefix($parts['path'], language_list());
      if ($language_obj) {
        $parts['path'] = $path;
        $parts['language_obj'] = $language_obj;
      }
    }
  }

  // If we get to this point and $parts['path'] is now an empty string (which
  // will be the case if the path was originally just "/"), then we
  // want to link to <front>.
  if ($parts['path'] === '') {
    $parts['path'] = '<front>';
  }
  // Build the parameters we will send to url()
  $url_params = array(
    'path' => $parts['path'],
    'options' => array(
      'query' => $parts['qparts'],
      'fragment' => isset($parts['fragment']) ? $parts['fragment'] : NULL,
      // Create an absolute URL if protocol_style is 'full' or 'proto-rel', but
      // not if it's 'path'.
      'absolute' => $cached_settings['current_settings']['protocol_style'] !== 'path',
      // If we seem to have found a language for the path, pass it along to
      // url(). Otherwise, ignore the 'language' parameter.
      'language' => isset($parts['language_obj']) ? $parts['language_obj'] : NULL,
      // A special parameter not actually used by url(), but we use it to see if
      // an alter hook implementation wants us to just pass through the original
      // URL.
      'use_original' => FALSE,
    ),
  );

  // Add the original URL to the parts array
  $parts['original'] = $original_url;

  // Now alter!
  // @see http://drupal.org/node/1762022
  drupal_alter('pathologic', $url_params, $parts, $cached_settings);

  // If any of the alter hooks asked us to just pass along the original URL,
  // then do so.
  if ($url_params['options']['use_original']) {
    return $matches[0];
  }

  // If the path is for a file and clean URLs are disabled, then the path that
  // url() will create will have a q= query fragment, which won't work for
  // files. To avoid that, we use this trick to temporarily turn clean URLs on.
  // This is horrible, but it seems to be the sanest way to do this.
  // @see http://drupal.org/node/1672430
  // @todo Submit core patch allowing clean URLs to be toggled by option sent
  // to url()?
  if (!empty($cached_settings['is_file'])) {
    $cached_settings['orig_clean_url'] = !empty($GLOBALS['conf']['clean_url']);
    if (!$cached_settings['orig_clean_url']) {
      $GLOBALS['conf']['clean_url'] = TRUE;
    }
  }

  // Now for the url() call. Drumroll, please…
  $url = url($url_params['path'], $url_params['options']);

  // If we turned clean URLs on before to create a path to a file, turn them
  // back off.
  if ($cached_settings['is_file'] && !$cached_settings['orig_clean_url']) {
    $GLOBALS['conf']['clean_url'] = FALSE;
  }

  // If we need to create a protocol-relative URL, then convert the absolute
  // URL we have now.
  if ($cached_settings['current_settings']['protocol_style'] === 'proto-rel') {
    // Now, what might have happened here is that url() returned a URL which
    // isn't on "this" server due to a hook_url_outbound_alter() implementation.
    // We don't want to convert the URL in that case. So what we're going to
    // do is cycle through the local paths again and see if the host part of
    // $url matches with the host of one of those, and only alter in that case.
    $url_parts = @parse_url($url);
    if (!empty($url_parts['host']) && $url_parts['host'] === $cached_settings['current_settings']['base_url_host']) {
      $url = _pathologic_url_to_protocol_relative($url);
    }
  }

  // Apply HTML character encoding, as is required for HTML attributes.
  // @see http://drupal.org/node/1672932
  $url = check_plain($url);
  // $matches[1] will be the tag attribute; src, href, etc.
  return " {$matches[1]}=\"{$url}";
}

/**
 * Convert a full URL with a protocol to a protocol-relative URL.
 *
 * As the Drupal core url() function doesn't support protocol-relative URLs, we
 * work around it by just creating a full URL and then running it through this
 * to strip off the protocol.
 *
 * Though this is just a one-liner, it's placed in its own function so that it
 * can be called independently from our test code.
 */
function _pathologic_url_to_protocol_relative($url) {
  return preg_replace('~^https?://~', '//', $url);
}
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                                      <h1 id="page-title">#for_researcher</h1>
                  
                  
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              <h1 class="node-title">
          <a href="/it/il-fenotipo-di-obesit-sarcopenica-negli-anziani-con-storia-di-cadute-0" rel="bookmark">Il fenotipo di obesità sarcopenica negli anziani con storia di cadute</a>
        </h1>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md1"><div class="field-item even"><h3>Y.R. Huo, P. Suriyaarachchi, F. Gomez, et al.</h3>
<p><em><span class="bold">Arch Gerontol Geriatr. 2016;65:255-9</span></em></p>
<p>L’obiettivo di questo studio è quello di ottenere un fenotipo completo di obesità sarcopenica in una popolazione ad alto rischio. Gli autori hanno trovato che i soggetti con obesità sarcopenica erano anziani (81.1±7.3), per lo più donne e con tendenza ad avere una scarsa densità minerale ossea, bassa forza di presa della mano, bassa velocità di deambulazione e scarso equilibrio. I soggetti con obesità sarcopenica inoltre presentavano elevati livelli di ormone paratirioideo e bassi livelli di vitamina D.&nbsp;</p>
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<article id="node-400" class="node node-tabs-article node-teaser article even node-lang-it iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/it/associazione-della-fragilit-con-la-serina-proteasi-htra1negli-anziani" rel="bookmark">Associazione della fragilità con la serina proteasi HtrA1negli anziani </a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md2"><div class="field-item even"><h3>M. Lorenzi, T. Lorenzi, E. Marzetti, et al.</h3>
<p><em><span class="bold">Exp Gerontol. 2016;81:8-12</span></em></p>
<p>La serina proteasi A1 richiedente elevate temperature (HtrA1) è una serina proteasi con multi dominio che viene secreta, ed è implicata nella inibizione della segnalazione che permette l’attivazione del fattore di crescita beta(TGF-β) 1, ovvero di una citochina che ricopre un importante ruolo antinfiammatorio. I risultati del presente studio dimostrano l’associazione dei livelli plasmatici di HtrA1 con lo stato di fragilità.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/associazione-della-fragilit-con-la-serina-proteasi-htra1negli-anziani" rel="tag" title="Associazione della fragilità con la serina proteasi HtrA1negli anziani ">Leggi tutto<span class="element-invisible"> su Associazione della fragilità con la serina proteasi HtrA1negli anziani </span></a></li></ul></nav>
  
  
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<article id="node-395" class="node node-tabs-article node-teaser article odd node-lang-it iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/it/associazione-tra-le-dimensioni-e-la-densit-dei-muscoli-del-tronco-ricavate-mediante-tomografia" rel="bookmark">Associazione tra le dimensioni e la densità dei muscoli del tronco ricavate mediante tomografia computerizzata con l’equilibrio e le cadute negli anziani </a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md3"><div class="field-item even"><h3>D.E. Anderson, E. Quinn, E. Parker, et al.</h3>
<p><em><span class="bold">J Gerontol A Biol Sci Med Sci. 2016;71(6):811-6</span></em></p>
<p>L’invecchiamento è associato al declino significativo delle dimensioni e della densità dei muscoli del tronco, ma l’associazione della densità e delle dimensioni dei muscoli del tronco con l’equilibrio e le cadute negli anziani non è stato mai studiato fino ad ora.</p>
<p>I risultati ottenuti in questo studio, suggeriscono che un’elevata densità muscolare si associa a ridotte oscillazioni posturali, in particolare ad oscillazioni della velocità, sia negli uomini che nelle donne, inoltre si associa ad un migliore risultato nella Short Physical Performance Battery (SPPB)&nbsp;ma non alle cadute.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/associazione-tra-le-dimensioni-e-la-densit-dei-muscoli-del-tronco-ricavate-mediante-tomografia" rel="tag" title="Associazione tra le dimensioni e la densità dei muscoli del tronco ricavate mediante tomografia computerizzata con l’equilibrio e le cadute negli anziani ">Leggi tutto<span class="element-invisible"> su Associazione tra le dimensioni e la densità dei muscoli del tronco ricavate mediante tomografia computerizzata con l’equilibrio e le cadute negli anziani </span></a></li></ul></nav>
  
  
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<article id="node-390" class="node node-tabs-article node-teaser article even node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli" rel="bookmark">Effetto dell’assunzione con la dieta di supplementi di n-3 PUFA sul trascrittoma muscolare negli anziani</a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md4"><div class="field-item even"><h3>J. Yoshino, G.I. Smith, S.C. Kelly, et al.</h3>
<p><em><span class="bold">Physiol Rep. 2016;4(11). pii: e12785</span></em></p>
<p>In questo studio abbiamo utilizzato dei campioni bioptici raccolti durante un recente studio clinico randomizzato controllato, il quale ha trovato che la terapia con supplementi di acidi grassi omega-3 aumenta la massa e la funzione muscolare, al fine di fornire una valutazione comprensiva dell'effetto della terapia a base di acidi grassi omega-3 sul profilo d'espressione genica nella muscolatura scheletrica di questi soggetti.</p>
<p>I dati ottenuti suggeriscono che la terapia con acidi grassi omega-3determina dei piccoli ma coordinati cambiamenti nel trascrittoma muscolare, questo può aiutare a spiegare i miglioramenti indotti da acidi grassi omega-3 sulla massa e funzione muscolare.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli" rel="tag" title="Effetto dell’assunzione con la dieta di supplementi di n-3 PUFA sul trascrittoma muscolare negli anziani">Leggi tutto<span class="element-invisible"> su Effetto dell’assunzione con la dieta di supplementi di n-3 PUFA sul trascrittoma muscolare negli anziani</span></a></li></ul></nav>
  
  
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<article id="node-385" class="node node-tabs-article node-teaser article odd node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/invecchiamento-di-successo-e-fragilit-facce-opposte-della-stessa-medaglia-0" rel="bookmark">Invecchiamento di successo e fragilità: facce opposte della stessa medaglia? </a>
        </h1>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md5"><div class="field-item even"><h3>J. Woo, J. Leung e T. Zhang</h3>
<p><em><span class="bold">J Am Med Dir Assoc. 2016;17(9):797-801</span></em></p>
<p>Questo studio esplora le ipotesi che descrivono l’invecchiamento di successo e la fragilità come due facce appartenenti alla stessa medaglia. Inoltre viene descritto l’uso della velocità del cammino come indicatore obbiettivo dell’invecchiamento di successo.</p>
<p>Chi camminava velocemente presentava una migliore salute auto-riportata, minore prevalenza di ictus, di ipertensione, di cataratta, di osteoporosi e di compromissione cognitiva. Coloro che assumevano frequentemente alcol, che erano fisicamente attivi e che consumavano quantità maggiori di verdure, presentavano una migliore qualità di vita, un minore indice di massa corporea, una minore percentuale di grasso appendicolare e totale, un maggiore indice di massa muscolare appendicolare e avevano ricevuto maggiore istruzione.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/invecchiamento-di-successo-e-fragilit-facce-opposte-della-stessa-medaglia-0" rel="tag" title="Invecchiamento di successo e fragilità: facce opposte della stessa medaglia? ">Leggi tutto<span class="element-invisible"> su Invecchiamento di successo e fragilità: facce opposte della stessa medaglia? </span></a></li></ul></nav>
  
  
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<article id="node-380" class="node node-tabs-article node-teaser article even node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/l-attivit-fisica-svolta-la-sera-aumenta-la-sintesi-proteica-muscolare-notturna-risposta-all" rel="bookmark">L’attività fisica svolta la sera aumenta la sintesi proteica muscolare notturna in risposta all’ingestione di proteine, negli uomini anziani prima del sonno</a>
        </h1>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md6"><div class="field-item even"><h3>A.M. Holwerda, I.W. Kouw, J. Trommelen, et al.</h3>
<p><em><span class="bold">J Nutr. 2016;146(7):1307-14</span></em></p>
<p>Il presente studio ha valutato se l’attività fisica svolta la sera può aumentare la sintesi proteica notturna nei muscoli, negli uomini anziani prima del sonno, in risposta all’ingestione di proteine. I risultati ottenuti suggeriscono che l’attività fisica svolta la sera aumenta la sintesi proteica notturna nei muscoli in risposta all’ingestione di proteine negli uomini anziani prima del sonno, e che permette ad un numero maggiore di amminoacidi ingeriti, di essere utilizzati per la sintesi proteica muscolare de novo durante il sonno.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/l-attivit-fisica-svolta-la-sera-aumenta-la-sintesi-proteica-muscolare-notturna-risposta-all" rel="tag" title="L’attività fisica svolta la sera aumenta la sintesi proteica muscolare notturna in risposta all’ingestione di proteine, negli uomini anziani prima del sonno">Leggi tutto<span class="element-invisible"> su L’attività fisica svolta la sera aumenta la sintesi proteica muscolare notturna in risposta all’ingestione di proteine, negli uomini anziani prima del sonno</span></a></li></ul></nav>
  
  
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<article id="node-370" class="node node-tabs-article node-teaser article odd node-lang-it iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/it/marcatori-sierici-di-infiammazione-e-di-stress-ossidativo-nella-sarcopenia-0" rel="bookmark">Marcatori sierici di infiammazione e di stress ossidativo nella sarcopenia </a>
        </h1>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md7"><div class="field-item even"><h3>B. Can, O. Kara, M.C. Kizilarslanoglu, et al.</h3>
<p><em><span class="bold">Aging Clin Exp Res. 2017;29(4):745-752</span></em></p>
<p>L’obiettivo di questo studio è quello di valutare la relazione tra la sarcopenia e i biomarcatori che possono essere coinvolti nella sua patogenesi e quindi di consentirne la diagnosi precoce. Il presente studio ha dimostrato la presenza di una associazione tra la sarcopenia e i marcatori dell’infiammazione CRP, il tasso di sedimentazione eritrocitaria e l’ adiponectina.</p>
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<article id="node-287" class="node node-tabs-article node-teaser article even node-lang-it iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/it/stima-della-prevalenza-di-sarcopenia-mediante-strumenti-differenti" rel="bookmark">Stima della prevalenza di sarcopenia mediante strumenti differenti</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md8"><div class="field-item even"><h3>C. Beaudart, J.Y. Reginster, J. Slomian, et al.</h3>
<p><em><span class="bold">Experimental Gerontology. 2015;61:31-7</span></em></p>
<p>Questo studio ha come obiettivo quello di valutare la prevalenza di sarcopenia in relazione allo strumento adottato per misurare le variabili relative alla massa muscolare, forza muscolare e performance fisica. I risultati ottenuti mostrano che, in base allo strumento utilizzato, la prevalenza di sarcopenia varia tra l’8.4% e il 27.6%. Inoltre è stato osservato che la metodica di valutazione dell’impedenza bioelettrica (BIA) tende a sovrastimare la massa muscolare rispetto all’assorbimetria a raggi X a doppia energia (DXA). Allo stesso modo, per quanto riguarda la forza muscolare, è stato visto che in dinamometro pneumatico diagnostica il doppio dei soggetti sarcopenici rispetto al dinamometro idraulico.</p>
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