Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty "cytokinome" at its core

E. Marzetti, A. Picca, F. Marini, et al.

Exp Gerontol. 2019;122:129-138

This study was designed to explore the association between a large panel of inflammatory biomolecules and physical frailty and sarcopenia in older adults through a multivariate statistical approach. Gender-specific inflammatory patterns were also explored.


High flavonoid cocoa supplement ameliorates plasma oxidative stress and inflammation levels while improving mobility and quality of life in older subjects: a double blind randomized clinical trial

L. Munguia, I. Rubio-Gayosso, I. Ramirez-Sanchez, et al.

J Gerontol A Biol Sci Med Sci. 2019 May 6. pii: glz107. doi: 10.1093/gerona/glz107. [Epub ahead of print]

The age-related decline in mass, strength and performance of skeletal muscle is associated with loss of independence, falls risk, disability, institutionalization and death.

To determine whether a cocoa supplement enriched in flavonoids can improve plasma markers of oxidative stress and inflammation, physical performance and frailty in middle and older age subjects, we conducted a two-phase, randomized, double blind, clinical trial.


Effects of dietary patterns and low protein intake on sarcopenia risk in the very old: The Newcastle 85+ study

A. Granic, N. Mendonça, A.A. Sayer, et al.

Clin Nutr. 2019 Jan 21. pii: S0261-5614(19)30011-1. doi: 10.1016/j.clnu.2019.01.009. [Epub ahead of print]

The aim was to investigate the association between healthy dietary patterns DPs and the risk of sarcopenia over 3 years, and to determine whether protein intake influences this relationship in community-dwelling older adults from the Newcastle 85 + Study.


Higher protein intake is associated with a lower likelihood of frailty among older women, Kuopio OSTPRE-Fracture Prevention Study

M. Isanejad, J. Sirola, T. Rikkonen, et al.

Eur J Nutr. 2019 May 7. doi: 10.1007/s00394-019-01978-7. [Epub ahead of print]

Nordic nutrition recommendations (2012) suggest protein intake ≥ 1.1 g/kg body weight (BW) to preserve physical function in Nordic older adults. However, no published study has used this cut-off to evaluate the association between protein intake and frailty. This study examined associations between protein intake, and sources of protein intake, with frailty status at the 3-year follow-up.


Associations between dietary patterns at age 71 and the prevalence of sarcopenia 16 years later

M. Karlsson, W. Becker, K. Michaëlsson, et al.

Clin Nutr. 2019 Apr 18. pii: S0261-5614(19)30182-7. doi: 10.1016/j.clnu.2019.04.009. [Epub ahead of print]

The growing recognition of the significance of sarcopenia has highlighted the need to understand etiologic factors, where food intake likely plays a role. The aim was to investigate the association between dietary patterns at mean age 71 and the prevalence of sarcopenia at mean age 87 in a Swedish cohort of community dwelling men.


Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study

K. Liberman, R. Njemini, Y. Luiking, et al.

Aging Clin Exp Res. 2019 May 2. doi: 10.1007/s40520-019-01208-4. [Epub ahead of print]

A chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited. The aim was to investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis.


Sex-specific differences in the association of vitamin D with low lean mass and frailty: Results from the Berlin Aging Study II

D. Spira, N. Buchmann, M. König, et al.

Nutrition. 2019;62:1-6

Sex-specific differences in factors associated with aging and lifespan, such as sarcopenia and disease development, are increasingly recognized. The study aims to assess sex-specific aspects of the association between vitamin D insufficiency and low lean mass as well as between vitamin D insufficiency and the frailty phenotype.


Phase angle and metabolic equivalents as predictors of frailty transitions in advanced age

B.M. Zanforlini, C. Trevisan, A. Bertocco, et al.

Exp Gerontol. 2019 Apr 24. pii: S0531-5565(19)30121-4. doi: 10.1016/j.exger.2019.04.016. [Epub ahead of print]

The aim of this prospective study was to investigate whether two cellular and metabolic health indices, phase angle (PhA) and metabolic equivalents (METs), can predict changes in frailty states in fit community-dwelling older people.


Ultrasound measurement of rectus femoris muscle thickness as a quick screening test for sarcopenia assessment

K. Rustani, L. Kundisova, P.L. Capecchi, et al.

Arch Gerontol Geriatr. 2019;83:151-154

According to European Working Group on Sarcopenia in Older People (EWGSOP) the diagnosis of sarcopenia requires the assessment of muscle mass, muscle force and function, that is time-consuming and not easily at hand in everyday clinical practice. We propose the B-mode ultrasound measurement of muscle thickness as a quick screening test to assess the presence of sarcopenia.


Effects of IGF-1 isoforms on muscle growth and sarcopenia

F. Ascenzi, L. Barberi, G. Dobrowolny, et al.

Aging Cell. 2019 Apr 5:e12954. doi: 10.1111/acel.12954. [Epub ahead of print]

The insulin-like growth factor-1 (IGF-1) has been implicated in many anabolic pathways in skeletal muscle. IGF-1 exists in different isoforms that might exert different role in skeletal muscle. Here we study the effects of two full propeptides IGF-1Ea and IGF-1Eb in skeletal muscle, with the aim to define whether and through which mechanisms their overexpression impacts muscle aging.



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