Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention

C.W. Li, K. Yu, N. Shyh-Chang, et al.

J Cachexia Sarcopenia Muscle. 2019 Apr 10. doi: 10.1002/jcsm.12417. [Epub ahead of print]

In this study, we evaluated whether proinflammatory cytokines are associated with the onset of sarcopenia, which circulating factors are associated with the severity of sarcopenia, and how these factors change after lifestyle interventions in sarcopenic elderly persons.


Muscle mass and strength gains following 6 months of resistance type exercise training are only partly preserved within one year with autonomous exercise continuation in older adults

T. Snijders, M. Leenders, L.C.P.G.M. de Groot, et al.

Exp Gerontol. 2019;121:71-78.

Although resistance type exercise training (RT) effectively increases muscle mass and strength in older individuals, it remains unclear whether gains in muscle mass and strength are maintained without continued supervised training. We assessed the capacity of older individuals to maintain muscle mass and strength gains one year after partaking in a successful RT program.


Dietary Patterns, Skeletal Muscle Health, and Sarcopenia in Older Adults

A. Granic, A.A. Sayer, S.M. Robinson

Nutrients. 2019 Mar 30;11(4). pii: E745. doi: 10.3390/nu11040745.

The prevalence of sarcopenia increases with age and leads to high personal, social, and economic costs. Finding adequate nutritional measures to maintain muscle health, preserve function, and independence for the growing population of older adults would have important scientific and societal implications.


The Impact of Physical Activity and Sedentary Behaviors on Frailty Levels

D.S. Kehler, O. Theou

Mech Ageing Dev. 2019 Mar 26. pii: S0047-6374(18)30244-6. doi: 10.1016/j.mad.2019.03.004. [Epub ahead of print]

Here, we summarize epidemiological and clinical trial evidence concerning the impact of physical activity and sedentary behaviors on frailty levels. We also analysed the National Health and Nutrition Examination Survey (NHANES) data to describe physical activity and sedentary behavior accumulation patterns across frailty levels and their impact on mortality risk.


Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence

K.J. Yoon, D. Zhang, S.J. Kim, et al.

Biochem Biophys Res Commun. 2019 Mar 22. pii: S0006-291X(19)30475-9. doi: 10.1016/j.bbrc.2019.03.086. [Epub ahead of print]

Here we show that pre-activation of AMPK with the AMPK activator, AICAR can mitigate the diminished cellular viability of skeletal muscle cells induced by doxorubicin, which accelerates senescence through free radical production.


A comparison between an ICT tool and a traditional physical measure for frailty evaluation in older adults

A. Mulasso, P.R. Brustio, A. Rainoldi, et al.

BMC Geriatr. 2019;19(1):88.

This study aimed to: i) evaluate differences in the mobility index (MI) provided by ADAMO system, an innovative remote monitoring device for older adults; ii) compare the association of the MI and a traditional physical measure with frailty.


Establishing the Link Between Lean Mass and Grip Strength Cut-points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference

P.M. Cawthon, T.G. Travison, T.M. Manini, et al.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14. pii: glz081. doi: 10.1093/gerona/glz081. [Epub ahead of print]

Lack of consensus on how to diagnose sarcopenia has limited the ability to diagnose this condition and hindered drug development. The Sarcopenia Definitions and Outcomes Consortium (SDOC) was formed to develop evidence-based diagnostic cut-points for lean mass and/or muscle strength that identify people at increased risk of mobility disability. We describe here the proceedings of a meeting of SDOC and other experts to discuss strategic considerations in the development of evidence-based sarcopenia definition.


Nutritional interventions to prevent and treat frailty

A.J. Cruz-Jentoft, J. Woo

Curr Opin Clin Nutr Metab Care. 2019 Feb 18. doi: 10.1097/MCO.0000000000000556. [Epub ahead of print]

Frailty is a multidimensional condition common in older adults, where reduced resiliency leads to adverse outcomes. It has strong links with malnutrition and sarcopenia, mostly through muscle health. This review explores the links between nutrition and frailty from different perspectives.


Can Physical Activity Offset the Detrimental Consequences of Sedentary Time on Frailty? A Moderation Analysis in 749 Older Adults Measured With Accelerometers

A. Mañas, B.D. Pozo-Cruz, I. Rodríguez-Gómez, et al.

J Am Med Dir Assoc. 2019 Feb 6. pii: S1525-8610(18)30719-9. doi: 10.1016/j.jamda.2018.12.012. [Epub ahead of print]

The Johnson-Neyman technique determined that the estimated moderate-to-vigorous physical activity point was 27.25 minutes/d, from which sedentary time has no significant effect on frailty.


Exercise training increases skeletal muscle strength independent of hypertrophy in older adults aged 75 years and older

H. Lee, I.G. Kim, C. Sung, et al.

Geriatr Gerontol Int. 2019;19(3):265-270

We investigated whether exercise-mediated acquisition of muscle mass and strength would occur in a concurrent manner in older adults.

A total of 152 community-dwelling older adults (young-old aged 65-74 years, old-old aged >75 years) were allocated into either 8-week comprehensive exercise training or the control group.



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