Involvement of plasma miRNAs, muscle miRNAs and mitochondrial miRNAs in the pathophysiology of frailty

I. Rusanova, J. Fernández-Martínez, M. Fernández-Ortiz, et al.

Exp Gerontol. 2019;124:110637

microRNAs are the one of multiple epigenetic biomarkers that reflect functional changes in aged subject. In this review we analyze microRNAs as molecules involved in the control of the pathways leading to the development of frailty.


A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial

Y. Bo, C. Liu, Z. Ji, et al.

Clin Nutr. 2019;38(1):159-164

Sarcopenia, an age-related decline of muscle mass, strength, and physical function, was associated with falls, frailty, and poor quality of life. The aim of the current study is to examine the effect of nutritional supplement containing whey protein, vitamin D and E on measures of sarcopenia.


The Effect of β-hydroxy-β-methylbutyrate (HMB) on Sarcopenia and Functional Frailty in Older Persons: A Systematic Review

J. Oktaviana, J. Zanker, S. Vogrin, et al.

J Nutr Health Aging. 2019;23(2):145-150

Beta-hydroxy-beta-methylbutyrate (HMB) has been shown to be effective and superior to other types of protein supplements to attenuate loss of muscle mass, strength and function, however, its benefits in sarcopenic and frail older people remain unclear.

We seek to determine the effect of HMB on muscle mass, strength and function in older people with sarcopenia or frailty by reviewing results from available randomized controlled trials (RCTs).


Effects of branched-chain amino acids and vitamin D supplementation on physical function, muscle mass and strength, and nutritional status in sarcopenic older adults undergoing hospital-based rehabilitation: A multicenter randomized controlled trial

I. Takeuchi, Y. Yoshimura, S. Shimaz, et al.

Geriatr Gerontol Int. 2019;19(1):12-17

The aim was to investigate the effects of branched-chain amino acids and vitamin D supplementation on physical function, muscle strength, muscle mass, and nutritional status in sarcopenic older adults undergoing hospital-based rehabilitation.


Higher dietary nitrate intake is associated with better muscle function in older women

M. Sim, J.R. Lewis, L.C. Blekkenhorst, et al.

J Cachexia Sarcopenia Muscle. 2019 Mar 24. doi: 10.1002/jcsm.12413. [Epub ahead of print]

The role of higher habitual nitrate intake as part of a typical diet on muscle function in ageing has not been investigated.  In this article a  cross-sectional study of relationships between dietary nitrate and measures of muscle function in older community-dwelling Australian women (n = 1420, ≥70 years) was undertaken.


Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men

A.M. Holwerda, K.J.M. Paulussen, M. Overkamp, et al.

Am J Physiol Endocrinol Metab. 2019 May 21. doi: 10.1152/ajpendo.00073.2019. [Epub ahead of print]

We investigated whether co-ingestion of 1.5 g free leucine with a single, 15 g bolus of protein further augments the post-prandial muscle protein synthetic response during recovery from resistance-type exercise in older men.


Consequences of applying the new EWGSOP2 guideline instead of the former EWGSOP guideline for sarcopenia case finding in older patients

J. Reiss, B. Iglseder, R. Alzner, et al.

Age Ageing. 2019 May 21. pii: afz035. doi: 10.1093/ageing/afz035. [Epub ahead of print]

We examined the consequences of applying the new EWGSOP2 algorithm for sarcopenia screening instead of the former EWGSOP algorithm (EWGSOP1) in geriatric inpatients.


Smoking and Diabetes as Predictive Factors of Accelerated Loss of Muscle Mass in Middle-Aged and Older Women: A Six-Year Retrospective Cohort Study

N. Lee, C.J. Choi

J Womens Health (Larchmt). 2019 May 23. doi: 10.1089/jwh.2018.7527. [Epub ahead of print]

Preservation of muscle mass during aging reduces the risk of frailty and age-related chronic diseases. We investigated the lifestyle, psychological factors, and common cardiometabolic diseases associated with accelerated muscle loss in middle-aged and older women.


Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project

B. Hsu, V. Hirani, R.G. Cumming, et al.

J Gerontol A Biol Sci Med Sci. 2019;74(6):835-841

Previous studies demonstrated associations between interleukin-6 (IL-6) and frailty, but associations between a wide range of cytokines, chemokines, and growth factors with prevalent and incident frailty has not been studied.



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