The role of omega-3 in the prevention and treatment of sarcopenia

J. Dupont, L. Dedeyne, S. Dalle, et al.

Aging Clin Exp Res. 2019 Feb 19. doi: 10.1007/s40520-019-01146-1. [Epub ahead of print]

This narrative review provides an overview of the current knowledge about omega-3 PUFAs and their role in the prevention and treatment of sarcopenia. We conclude that there is growing evidence for a beneficial effect of omega-3 PUFAs supplementation in sarcopenic older persons, which may add to the effect of exercise and/or protein supplementation.


Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

H. Neelakantan, C.R. Brightwell, T.G. Graber, et al.

Biochem Pharmacol. 2019 Feb 9. pii: S0006-2952(19)30046-2. doi: 10.1016/j.bcp.2019.02.008. [Epub ahead of print]

We recently developed small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed with aging in skeletal muscles and linked to impairment of the NAD+ salvage pathway, dysregulated sirtuin 1 activity, and increased muSC senescence. We hypothesized that NNMT inhibitor (NNMTi) treatment will rescue age-related deficits in muSC activity to promote superior regeneration post-injury in aging muscle.


Cross-sectional associations of dietary and circulating magnesium with skeletal muscle mass in the EPIC-Norfolk cohort

R.P.G. Hayhoe, M.A.H. Lentjes, A.A. Mulligan, et al.

Clin Nutr.2019;38(1):317-323

This study aimed to investigate the influence of dietary and circulating magnesium on skeletal muscle mass in a UK population of 14,340 middle to older-aged men and women participating in the EPIC-Norfolk cohort study.


Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

A. Santoro, G. Guidarelli, R. Ostan, et al.

Eur Radiol. 2019 Feb 4. doi: 10.1007/s00330-018-5973-2. [Epub ahead of print]

The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.


Prospective Views for Whey Protein and/or Resistance Training Against Age-related Sarcopenia

Y. Liao, Z. Peng, L. Chen, et al.

Aging Dis. 2019;10(1):157-173

Whey protein and/or resistance training has shown promise in preventing and treating age-related sarcopenia. Sex hormones could be potential contributors for gender differences in skeletal muscle and age-related sarcopenia. In addition, skeletal muscle and the development of sarcopenia are influenced by gut microbiota.


Biological Processes and Biomarkers Related to Frailty in Older Adults: A State-of-the-Science Literature Review

J. Wang, C.A. Maxwell, F. Yu

Biol Res Nurs. 2019;21(1):80-106

The objectives of this literature review were to (1) synthesize biological processes linked to frailty and their corresponding biomarkers and (2) identify potential associations among these processes and biomarkers.


Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

D.D. Huang, S.D. Fan, X.Y. Chen, et al.

Exp Gerontol. 2019 Jan 25. pii: S0531-5565(18)30615-6. doi: 10.1016/j.exger.2019.01.022. [Epub ahead of print]

Mitochondrial dysfunction during aging is a key factor that contributes to sarcopenia. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been increasingly recognized to regulate mitochondrial function. The present study aimed to investigate the role of Nrf2 in the development of frailty and sarcopenia during aging, and to demonstrate whether Nrf2 contributes to the maintenance of muscle mass and function by regulation of mitochondrial biogenesis and dynamics during the aging process.



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