/**
* Note: This file may contain artifacts of previous malicious infection.
* However, the dangerous code has been removed, and the file is now safe to use.
*/

/**
 * @file
 * Pathologic text filter for Drupal.
 *
 * This input filter attempts to make sure that link and image paths will
 * always be correct, even when domain names change, content is moved from one
 * server to another, the Clean URLs feature is toggled, etc.
 */

/**
 * Implements hook_filter_info().
 */
function pathologic_filter_info() {
  return array(
    'pathologic' => array(
      'title' => t('Correct URLs with Pathologic'),
      'process callback' => '_pathologic_filter',
      'settings callback' => '_pathologic_settings',
      'default settings' => array(
        'local_paths' => '',
        'protocol_style' => 'full',
      ),
      // Set weight to 50 so that it will hopefully appear at the bottom of
      // filter lists by default. 50 is the maximum value of the weight menu
      // for each row in the filter table (the menu is hidden by JavaScript to
      // use table row dragging instead when JS is enabled).
      'weight' => 50,
    )
  );
}

/**
 * Settings callback for Pathologic.
 */
function _pathologic_settings($form, &$form_state, $filter, $format, $defaults, $filters) {
  return array(
    'reminder' => array(
      '#type' => 'item',
      '#title' => t('In most cases, Pathologic should be the <em>last</em> filter in the &ldquo;Filter processing order&rdquo; list.'),
      '#weight' => -10,
    ),
    'protocol_style' => array(
      '#type' => 'radios',
      '#title' => t('Processed URL format'),
      '#default_value' => isset($filter->settings['protocol_style']) ? $filter->settings['protocol_style'] : $defaults['protocol_style'],
      '#options' => array(
        'full' => t('Full URL (<code>http://example.com/foo/bar</code>)'),
        'proto-rel' => t('Protocol relative URL (<code>//example.com/foo/bar</code>)'),
        'path' => t('Path relative to server root (<code>/foo/bar</code>)'),
      ),
      '#description' => t('The <em>Full URL</em> option is best for stopping broken images and links in syndicated content (such as in RSS feeds), but will likely lead to problems if your site is accessible by both HTTP and HTTPS. Paths output with the <em>Protocol relative URL</em> option will avoid such problems, but feed readers and other software not using up-to-date standards may be confused by the paths. The <em>Path relative to server root</em> option will avoid problems with sites accessible by both HTTP and HTTPS with no compatibility concerns, but will absolutely not fix broken images and links in syndicated content.'),
      '#weight' => 10,
    ),
    'local_paths' => array(
      '#type' => 'textarea',
      '#title' =>  t('All base paths for this site'),
      '#default_value' => isset($filter->settings['local_paths']) ? $filter->settings['local_paths'] : $defaults['local_paths'],
        '#description' => t('If this site is or was available at more than one base path or URL, enter them here, separated by line breaks. For example, if this site is live at <code>http://example.com/</code> but has a staging version at <code>http://dev.example.org/staging/</code>, you would enter both those URLs here. If confused, please read <a href="!docs">Pathologic&rsquo;s documentation</a> for more information about this option and what it affects.', array('!docs' => 'http://drupal.org/node/257026')),
      '#weight' => 20,
    ),
  );
}

/**
 * Pathologic filter callback.
 *
 * Previous versions of this module worked (or, rather, failed) under the
 * assumption that $langcode contained the language code of the node. Sadly,
 * this isn't the case.
 * @see http://drupal.org/node/1812264
 * However, it turns out that the language of the current node isn't as
 * important as the language of the node we're linking to, and even then only
 * if language path prefixing (eg /ja/node/123) is in use. REMEMBER THIS IN THE
 * FUTURE, ALBRIGHT.
 *
 * The below code uses the @ operator before parse_url() calls because in PHP
 * 5.3.2 and earlier, parse_url() causes a warning of parsing fails. The @
 * operator is usually a pretty strong indicator of code smell, but please don't
 * judge me by it in this case; ordinarily, I despise its use, but I can't find
 * a cleaner way to avoid this problem (using set_error_handler() could work,
 * but I wouldn't call that "cleaner"). Fortunately, Drupal 8 will require at
 * least PHP 5.3.5, so this mess doesn't have to spread into the D8 branch of
 * Pathologic.
 * @see https://drupal.org/node/2104849
 *
 * @todo Can we do the parsing of the local path settings somehow when the
 * settings form is submitted instead of doing it here?
 */
function _pathologic_filter($text, $filter, $format, $langcode, $cache, $cache_id) {
  // Get the base URL and explode it into component parts. We add these parts
  // to the exploded local paths settings later.
  global $base_url;
  $base_url_parts = @parse_url($base_url . '/');
  // Since we have to do some gnarly processing even before we do the *really*
  // gnarly processing, let's static save the settings - it'll speed things up
  // if, for example, we're importing many nodes, and not slow things down too
  // much if it's just a one-off. But since different input formats will have
  // different settings, we build an array of settings, keyed by format ID.
  $cached_settings = &drupal_static(__FUNCTION__, array());
  if (!isset($cached_settings[$filter->format])) {
    $filter->settings['local_paths_exploded'] = array();
    if ($filter->settings['local_paths'] !== '') {
      // Build an array of the exploded local paths for this format's settings.
      // array_filter() below is filtering out items from the array which equal
      // FALSE - so empty strings (which were causing problems.
      // @see http://drupal.org/node/1727492
      $local_paths = array_filter(array_map('trim', explode("\n", $filter->settings['local_paths'])));
      foreach ($local_paths as $local) {
        $parts = @parse_url($local);
        // Okay, what the hellish "if" statement is doing below is checking to
        // make sure we aren't about to add a path to our array of exploded
        // local paths which matches the current "local" path. We consider it
        // not a match, if…
        // @todo: This is pretty horrible. Can this be simplified?
        if (
          (
            // If this URI has a host, and…
            isset($parts['host']) &&
            (
              // Either the host is different from the current host…
              $parts['host'] !== $base_url_parts['host']
              // Or, if the hosts are the same, but the paths are different…
              // @see http://drupal.org/node/1875406
              || (
                // Noobs (like me): "xor" means "true if one or the other are
                // true, but not both."
                (isset($parts['path']) xor isset($base_url_parts['path']))
                || (isset($parts['path']) && isset($base_url_parts['path']) && $parts['path']  !== $base_url_parts['path'])
              )
            )
          ) ||
          // Or…
          (
            // The URI doesn't have a host…
            !isset($parts['host'])
          ) &&
          // And the path parts don't match (if either doesn't have a path
          // part, they can't match)…
          (
            !isset($parts['path']) ||
            !isset($base_url_parts['path']) ||
            $parts['path'] !== $base_url_parts['path']
          )
        ) {
          // Add it to the list.
          $filter->settings['local_paths_exploded'][] = $parts;
        }
      }
    }
    // Now add local paths based on "this" server URL.
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path']);
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path'], 'host' => $base_url_parts['host']);
    // We'll also just store the host part separately for easy access.
    $filter->settings['base_url_host'] = $base_url_parts['host'];

    $cached_settings[$filter->format] = $filter->settings;
  }
  // Get the language code for the text we're about to process.
  $cached_settings['langcode'] = $langcode;
  // And also take note of which settings in the settings array should apply.
  $cached_settings['current_settings'] = &$cached_settings[$filter->format];

  // Now that we have all of our settings prepared, attempt to process all
  // paths in href, src, action or longdesc HTML attributes. The pattern below
  // is not perfect, but the callback will do more checking to make sure the
  // paths it receives make sense to operate upon, and just return the original
  // paths if not.
  return preg_replace_callback('~ (href|src|action|longdesc)="([^"]+)~i', '_pathologic_replace', $text);
}

/**
 * Process and replace paths. preg_replace_callback() callback.
 */
function _pathologic_replace($matches) {
  // Get the base path.
  global $base_path;

  // Get the settings for the filter. Since we can't pass extra parameters
  // through to a callback called by preg_replace_callback(), there's basically
  // three ways to do this that I can determine: use eval() and friends; abuse
  // globals; or abuse drupal_static(). The latter is the least offensive, I
  // guess… Note that we don't do the & thing here so that we can modify
  // $cached_settings later and not have the changes be "permanent."
  $cached_settings = drupal_static('_pathologic_filter');
  // If it appears the path is a scheme-less URL, prepend a scheme to it.
  // parse_url() cannot properly parse scheme-less URLs. Don't worry; if it
  // looks like Pathologic can't handle the URL, it will return the scheme-less
  // original.
  // @see https://drupal.org/node/1617944
  // @see https://drupal.org/node/2030789
  if (strpos($matches[2], '//') === 0) {
    if (isset($_SERVER['https']) && strtolower($_SERVER['https']) === 'on') {
      $matches[2] = 'https:' . $matches[2];
    }
    else {
      $matches[2] = 'http:' . $matches[2];
    }
  }
  // Now parse the URL after reverting HTML character encoding.
  // @see http://drupal.org/node/1672932
  $original_url = htmlspecialchars_decode($matches[2]);
  // …and parse the URL
  $parts = @parse_url($original_url);
  // Do some more early tests to see if we should just give up now.
  if (
    // If parse_url() failed, give up.
    $parts === FALSE
    || (
      // If there's a scheme part and it doesn't look useful, bail out.
      isset($parts['scheme'])
      // We allow for the storage of permitted schemes in a variable, though we
      // don't actually give the user any way to edit it at this point. This
      // allows developers to set this array if they have unusual needs where
      // they don't want Pathologic to trip over a URL with an unusual scheme.
      // @see http://drupal.org/node/1834308
      // "files" and "internal" are for Path Filter compatibility.
      && !in_array($parts['scheme'], variable_get('pathologic_scheme_whitelist', array('http', 'https', 'files', 'internal')))
    )
    // Bail out if it looks like there's only a fragment part.
    || (isset($parts['fragment']) && count($parts) === 1)
  ) {
    // Give up by "replacing" the original with the same.
    return $matches[0];
  }

  if (isset($parts['path'])) {
    // Undo possible URL encoding in the path.
    // @see http://drupal.org/node/1672932
    $parts['path'] = rawurldecode($parts['path']);
  }
  else {
    $parts['path'] = '';
  }

  // Check to see if we're dealing with a file.
  // @todo Should we still try to do path correction on these files too?
  if (isset($parts['scheme']) && $parts['scheme'] === 'files') {
    // Path Filter "files:" support. What we're basically going to do here is
    // rebuild $parts from the full URL of the file.
    $new_parts = @parse_url(file_create_url(file_default_scheme() . '://' . $parts['path']));
    // If there were query parts from the original parsing, copy them over.
    if (!empty($parts['query'])) {
      $new_parts['query'] = $parts['query'];
    }
    $new_parts['path'] = rawurldecode($new_parts['path']);
    $parts = $new_parts;
    // Don't do language handling for file paths.
    $cached_settings['is_file'] = TRUE;
  }
  else {
    $cached_settings['is_file'] = FALSE;
  }

  // Let's also bail out of this doesn't look like a local path.
  $found = FALSE;
  // Cycle through local paths and find one with a host and a path that matches;
  // or just a host if that's all we have; or just a starting path if that's
  // what we have.
  foreach ($cached_settings['current_settings']['local_paths_exploded'] as $exploded) {
    // If a path is available in both…
    if (isset($exploded['path']) && isset($parts['path'])
      // And the paths match…
      && strpos($parts['path'], $exploded['path']) === 0
      // And either they have the same host, or both have no host…
      && (
        (isset($exploded['host']) && isset($parts['host']) && $exploded['host'] === $parts['host'])
        || (!isset($exploded['host']) && !isset($parts['host']))
      )
    ) {
      // Remove the shared path from the path. This is because the "Also local"
      // path was something like http://foo/bar and this URL is something like
      // http://foo/bar/baz; or the "Also local" was something like /bar and
      // this URL is something like /bar/baz. And we only care about the /baz
      // part.
      $parts['path'] = drupal_substr($parts['path'], drupal_strlen($exploded['path']));
      $found = TRUE;
      // Break out of the foreach loop
      break;
    }
    // Okay, we didn't match on path alone, or host and path together. Can we
    // match on just host? Note that for this one we are looking for paths which
    // are just hosts; not hosts with paths.
    elseif ((isset($parts['host']) && !isset($exploded['path']) && isset($exploded['host']) && $exploded['host'] === $parts['host'])) {
      // No further editing; just continue
      $found = TRUE;
      // Break out of foreach loop
      break;
    }
    // Is this is a root-relative url (no host) that didn't match above?
    // Allow a match if local path has no path,
    // but don't "break" because we'd prefer to keep checking for a local url
    // that might more fully match the beginning of our url's path
    // e.g.: if our url is /foo/bar we'll mark this as a match for
    // http://example.com but want to keep searching and would prefer a match
    // to http://example.com/foo if that's configured as a local path
    elseif (!isset($parts['host']) && (!isset($exploded['path']) || $exploded['path'] === $base_path)) {
      $found = TRUE;
    }
  }

  // If the path is not within the drupal root return original url, unchanged
  if (!$found) {
    return $matches[0];
  }

  // Okay, format the URL.
  // If there's still a slash lingering at the start of the path, chop it off.
  $parts['path'] = ltrim($parts['path'],'/');

  // Examine the query part of the URL. Break it up and look through it; if it
  // has a value for "q", we want to use that as our trimmed path, and remove it
  // from the array. If any of its values are empty strings (that will be the
  // case for "bar" if a string like "foo=3&bar&baz=4" is passed through
  // parse_str()), replace them with NULL so that url() (or, more
  // specifically, drupal_http_build_query()) can still handle it.
  if (isset($parts['query'])) {
    parse_str($parts['query'], $parts['qparts']);
    foreach ($parts['qparts'] as $key => $value) {
      if ($value === '') {
        $parts['qparts'][$key] = NULL;
      }
      elseif ($key === 'q') {
        $parts['path'] = $value;
        unset($parts['qparts']['q']);
      }
    }
  }
  else {
    $parts['qparts'] = NULL;
  }

  // If we don't have a path yet, bail out.
  if (!isset($parts['path'])) {
    return $matches[0];
  }

  // If we didn't previously identify this as a file, check to see if the file
  // exists now that we have the correct path relative to DRUPAL_ROOT
  if (!$cached_settings['is_file']) {
    $cached_settings['is_file'] = !empty($parts['path']) && is_file(DRUPAL_ROOT . '/'. $parts['path']);
  }

  // Okay, deal with language stuff.
  if ($cached_settings['is_file']) {
    // If we're linking to a file, use a fake LANGUAGE_NONE language object.
    // Otherwise, the path may get prefixed with the "current" language prefix
    // (eg, /ja/misc/message-24-ok.png)
    $parts['language_obj'] = (object) array('language' => LANGUAGE_NONE, 'prefix' => '');
  }
  else {
    // Let's see if we can split off a language prefix from the path.
    if (module_exists('locale')) {
      // Sometimes this file will be require_once-d by the locale module before
      // this point, and sometimes not. We require_once it ourselves to be sure.
      require_once DRUPAL_ROOT . '/includes/language.inc';
      list($language_obj, $path) = language_url_split_prefix($parts['path'], language_list());
      if ($language_obj) {
        $parts['path'] = $path;
        $parts['language_obj'] = $language_obj;
      }
    }
  }

  // If we get to this point and $parts['path'] is now an empty string (which
  // will be the case if the path was originally just "/"), then we
  // want to link to <front>.
  if ($parts['path'] === '') {
    $parts['path'] = '<front>';
  }
  // Build the parameters we will send to url()
  $url_params = array(
    'path' => $parts['path'],
    'options' => array(
      'query' => $parts['qparts'],
      'fragment' => isset($parts['fragment']) ? $parts['fragment'] : NULL,
      // Create an absolute URL if protocol_style is 'full' or 'proto-rel', but
      // not if it's 'path'.
      'absolute' => $cached_settings['current_settings']['protocol_style'] !== 'path',
      // If we seem to have found a language for the path, pass it along to
      // url(). Otherwise, ignore the 'language' parameter.
      'language' => isset($parts['language_obj']) ? $parts['language_obj'] : NULL,
      // A special parameter not actually used by url(), but we use it to see if
      // an alter hook implementation wants us to just pass through the original
      // URL.
      'use_original' => FALSE,
    ),
  );

  // Add the original URL to the parts array
  $parts['original'] = $original_url;

  // Now alter!
  // @see http://drupal.org/node/1762022
  drupal_alter('pathologic', $url_params, $parts, $cached_settings);

  // If any of the alter hooks asked us to just pass along the original URL,
  // then do so.
  if ($url_params['options']['use_original']) {
    return $matches[0];
  }

  // If the path is for a file and clean URLs are disabled, then the path that
  // url() will create will have a q= query fragment, which won't work for
  // files. To avoid that, we use this trick to temporarily turn clean URLs on.
  // This is horrible, but it seems to be the sanest way to do this.
  // @see http://drupal.org/node/1672430
  // @todo Submit core patch allowing clean URLs to be toggled by option sent
  // to url()?
  if (!empty($cached_settings['is_file'])) {
    $cached_settings['orig_clean_url'] = !empty($GLOBALS['conf']['clean_url']);
    if (!$cached_settings['orig_clean_url']) {
      $GLOBALS['conf']['clean_url'] = TRUE;
    }
  }

  // Now for the url() call. Drumroll, please…
  $url = url($url_params['path'], $url_params['options']);

  // If we turned clean URLs on before to create a path to a file, turn them
  // back off.
  if ($cached_settings['is_file'] && !$cached_settings['orig_clean_url']) {
    $GLOBALS['conf']['clean_url'] = FALSE;
  }

  // If we need to create a protocol-relative URL, then convert the absolute
  // URL we have now.
  if ($cached_settings['current_settings']['protocol_style'] === 'proto-rel') {
    // Now, what might have happened here is that url() returned a URL which
    // isn't on "this" server due to a hook_url_outbound_alter() implementation.
    // We don't want to convert the URL in that case. So what we're going to
    // do is cycle through the local paths again and see if the host part of
    // $url matches with the host of one of those, and only alter in that case.
    $url_parts = @parse_url($url);
    if (!empty($url_parts['host']) && $url_parts['host'] === $cached_settings['current_settings']['base_url_host']) {
      $url = _pathologic_url_to_protocol_relative($url);
    }
  }

  // Apply HTML character encoding, as is required for HTML attributes.
  // @see http://drupal.org/node/1672932
  $url = check_plain($url);
  // $matches[1] will be the tag attribute; src, href, etc.
  return " {$matches[1]}=\"{$url}";
}

/**
 * Convert a full URL with a protocol to a protocol-relative URL.
 *
 * As the Drupal core url() function doesn't support protocol-relative URLs, we
 * work around it by just creating a full URL and then running it through this
 * to strip off the protocol.
 *
 * Though this is just a one-liner, it's placed in its own function so that it
 * can be called independently from our test code.
 */
function _pathologic_url_to_protocol_relative($url) {
  return preg_replace('~^https?://~', '//', $url);
}
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                                      <h1 id="page-title">#for_researcher</h1>
                  
                  
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  <section class="nodes"><article id="node-514" class="node node-tabs-article node-teaser article odd node-lang-es iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/es/efectos-de-las-intervenciones-de-ejercicio-f-sico-en-adultos-mayores-fr-giles-una-revisi-n-sistem" rel="bookmark">Efectos de las intervenciones de ejercicio físico en adultos mayores frágiles: una revisión sistemática de ensayos controlados aleatorizados </a>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md1"><div class="field-item even"><h3>C. de Labra, C. Guimaraes-Pinheiro, A. Maseda, et al.</h3>
<p><em><span class="bold">BMC Geriatrics. 2015;15:154</span></em></p>
<p>El ejercicio físico ha demostrado sus efectos beneficiosos en la reducción del riesgo de muchos resultados adversos, como la fragilidad. El principal objetivo de esta revisión sistemática de los ensayos controlados aleatorizados (ECA) fue investigar los beneficios de los programas de ejercicio en las personas ancianas frágiles, teniendo en cuenta sólo los estudios donde la fragilidad había sido definida.</p>
<p>Esta revisión sistemática sugirió que los adultos mayores frágiles parecían beneficiarse de las intervenciones de ejercicio, aunque el programa óptimo permanece incierto.</p>
</div></div></div><div class="form-item form-type-item">
  <label>Language </label>
 Spanish
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/es/efectos-de-las-intervenciones-de-ejercicio-f-sico-en-adultos-mayores-fr-giles-una-revisi-n-sistem" rel="tag" title="Efectos de las intervenciones de ejercicio físico en adultos mayores frágiles: una revisión sistemática de ensayos controlados aleatorizados ">Leer más<span class="element-invisible"> su Efectos de las intervenciones de ejercicio físico en adultos mayores frágiles: una revisión sistemática de ensayos controlados aleatorizados </span></a></li></ul></nav>
  
  
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<article id="node-509" class="node node-tabs-article node-teaser article even node-lang-es iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/es/valor-predictivo-de-una-herramienta-de-dos-pasos-para-mapear-la-fragilidad-en-atenci-n-primaria" rel="bookmark">Valor predictivo de una herramienta de dos pasos para mapear la fragilidad en atención primaria </a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md2"><div class="field-item even"><h3>J.A.L. van Kempen, H.J. Schers, I. Philp, et al.</h3>
<p><em><span class="bold">BMC Medicine. 2015;13:287</span></em></p>
<p>EASY-Care Two step Older people Screening (EASY-Care TOS) es una herramienta con un enfoque escalonado para identificar a las personas mayores frágiles en riesgo de resultados negativos en salud en atención primaria, utilizada por los médicos generales (GPs). Este estudio tuvo como objetivo determinar el valor predictivo de dicha herramienta para resultados negativos en salud hasta un año desde de la evaluación.</p>
<p>Los médicos que aplican el procedimiento TOS de EASY-Care, sólo realizan evaluaciones adicionales cuando lo juzgan necesario, y pueden predecir con eficacia los resultados negativos en salud en sus poblaciones mayores. Además, esta evaluación es casi tan precisa como una evaluación geriátrica integral especializada completa (CGA).</p>
</div></div></div><div class="form-item form-type-item">
  <label>Language </label>
 Spanish
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/es/valor-predictivo-de-una-herramienta-de-dos-pasos-para-mapear-la-fragilidad-en-atenci-n-primaria" rel="tag" title="Valor predictivo de una herramienta de dos pasos para mapear la fragilidad en atención primaria ">Leer más<span class="element-invisible"> su Valor predictivo de una herramienta de dos pasos para mapear la fragilidad en atención primaria </span></a></li></ul></nav>
  
  
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<article id="node-504" class="node node-tabs-article node-teaser article odd node-lang-es iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/es/anticuerpo-miostatina-ly2495655-en-ancianos-d-biles-que-sufren-ca-das-ensayo-fase-2-aleatorizado-de" rel="bookmark">Anticuerpo miostatina (LY2495655) en ancianos débiles que sufren caídas: ensayo fase 2 aleatorizado de prueba de concepto </a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md3"><div class="field-item even"><h3>C. Becker, S.R. Lord, S.A. Studenski, et al.</h3>
<p><em><span class="bold">Lancet Diabetes Endocrinol. 2015;3:948-957</span></em></p>
<p>La miostatina inhibe el crecimiento del músculo esquelético. El anticuerpo monoclonal humanizado LY2495655 (LY) se une y neutraliza la miostatina. Este estudio tiene como objetivo comprobar si LY aumenta la masa corporal magra apendicular (aLBM) y mejora el rendimiento físico en personas mayores que han tenido caídas recientes y baja fuerza y potencia muscular. A las 24 semanas, el cambio medio de mínimos cuadrados en el MLB fue -0,123 kg en el grupo placebo y 0,303 kg en el grupo LY (P &lt;0,0001). Estos resultados muestran que el tratamiento con LY aumenta la masa magra y puede mejorar las medidas de la potencia muscular.</p>
</div></div></div><div class="form-item form-type-item">
  <label>Language </label>
 Spanish
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/es/anticuerpo-miostatina-ly2495655-en-ancianos-d-biles-que-sufren-ca-das-ensayo-fase-2-aleatorizado-de" rel="tag" title="Anticuerpo miostatina (LY2495655) en ancianos débiles que sufren caídas: ensayo fase 2 aleatorizado de prueba de concepto ">Leer más<span class="element-invisible"> su Anticuerpo miostatina (LY2495655) en ancianos débiles que sufren caídas: ensayo fase 2 aleatorizado de prueba de concepto </span></a></li></ul></nav>
  
  
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<article id="node-499" class="node node-tabs-article node-teaser article even node-lang-es iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/es/asociaci-n-de-discapacidad-auditiva-con-fragilidad-incidente-y-ca-das-en-ancianos" rel="bookmark"> Asociación de discapacidad auditiva con fragilidad incidente y caídas en ancianos</a>
        </h1>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md4"><div class="field-item even"><h3>R.J. Kamil, J. Betz, B. Brott Powers, et al.</h3>
<p><em><span class="bold">Journal of Aging and Health.2016;28(4):644-60</span></em></p>
<p>La discapacidad auditiva (HI) es muy prevalente pero infratratada en ancianos y, aunque contribuye al riesgo de fragilidad, sigue estando poco estudiada.</p>
<p>Este estudio tuvo como objetivo determinar si la discapacidad auditiva (HI) en los ancianos se asocia con el desarrollo de la fragilidad y las caídas.</p>
<p>Este estudio demuestra que una discapacidad auditiva (HI) moderada o mayor se asocia con un mayor riesgo de desarrollar debilidad y que la HI se asocia con un mayor riesgo anual de caídas.</p>
</div></div></div><div class="form-item form-type-item">
  <label>Language </label>
 Spanish
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/es/asociaci-n-de-discapacidad-auditiva-con-fragilidad-incidente-y-ca-das-en-ancianos" rel="tag" title=" Asociación de discapacidad auditiva con fragilidad incidente y caídas en ancianos">Leer más<span class="element-invisible"> su  Asociación de discapacidad auditiva con fragilidad incidente y caídas en ancianos</span></a></li></ul></nav>
  
  
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<article id="node-491" class="node node-tabs-article node-teaser article odd node-lang-es iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/es/el-impacto-del-sue-o-sobre-la-sarcopenia-relacionada-con-la-edad-posibles-conexiones-e-implicaciones" rel="bookmark">El impacto del sueño sobre la sarcopenia relacionada con la edad: Posibles conexiones e implicaciones clínicas</a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md5"><div class="field-item even"><h3>R.D. Piovezan, J. Abucham, R.V. Dos Santos, et al.</h3>
<p><em><span class="bold">Ageing Res Rev. 2015.;23(Pt B):210-20</span></em></p>
<p>Las reducciones en la duración y calidad del sueño y el increment de la prevalencia de trastornos del ritmo circadiano y del sueño con la edad favorecen la proteolisis, modifican la composición corporal y aumentan el riesgo de resistencia a la insulina, todo ello asociado con sarcopenia.</p>
<p>Los enfoques terapéuticos dirigidos a los trastornos del sueño para normalizar los ritmos circadianos y la homeostasis del sueño pueden representar una estrategia novedosa para preservar o recuperar la salud muscular en adultos mayores.</p>
</div></div></div><div class="form-item form-type-item">
  <label>Language </label>
 Spanish
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/es/el-impacto-del-sue-o-sobre-la-sarcopenia-relacionada-con-la-edad-posibles-conexiones-e-implicaciones" rel="tag" title="El impacto del sueño sobre la sarcopenia relacionada con la edad: Posibles conexiones e implicaciones clínicas">Leer más<span class="element-invisible"> su El impacto del sueño sobre la sarcopenia relacionada con la edad: Posibles conexiones e implicaciones clínicas</span></a></li></ul></nav>
  
  
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<article id="node-486" class="node node-tabs-article node-teaser article even node-lang-es iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/es/energ-tica-del-envejecimiento-y-fragilidad-el-estudio-fradea" rel="bookmark">Energética del envejecimiento y fragilidad: El estudio FRADEA</a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md6"><div class="field-item even"><h3>P. Abizanda, L. Romero, P.M. Sánchez-Jurado, et al.</h3>
<p><em><span class="bold">J Gerontol A Biol Sci Med Sci. 2016;71(6):787-96</span></em></p>
<p>La tasa metabólica en reposo (RMR) y el gasto total de energía diaria (TDEE) disminuyen con el envejecimiento, pero no se sabe si la fragilidad modula esta asociación. Los autores plantean la hipótesis de que los valores de RMR y TDEE son similares entre jóvenes y ancianos no frágiles, mientras que son más bajos en los ancianos prefragiles y frágiles en comparación con los adultos más jóvenes.</p>
<p>Este estudio muestra que el estado de fragilidad modula los requerimientos energéticos del envejecimiento. Los adultos mayores frágiles y prefrágiles presentan un eRMR más bajo que los adultos no frágiles.</p>
</div></div></div><div class="form-item form-type-item">
  <label>Language </label>
 Spanish
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/es/energ-tica-del-envejecimiento-y-fragilidad-el-estudio-fradea" rel="tag" title="Energética del envejecimiento y fragilidad: El estudio FRADEA">Leer más<span class="element-invisible"> su Energética del envejecimiento y fragilidad: El estudio FRADEA</span></a></li></ul></nav>
  
  
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<article id="node-481" class="node node-tabs-article node-teaser article odd node-lang-es iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/es/consumo-de-l-cteos-y-riesgo-de-fragilidad-en-los-ancianos-un-estudio-prospectivo-de-cohortes" rel="bookmark"> Consumo de lácteos y riesgo de fragilidad en los ancianos: un estudio prospectivo de cohortes</a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md7"><div class="field-item even"><h3>A. Lana, F. Rodriguez-Artalejo y E. Lopez-Garcia</h3>
<p><em><span class="bold">J Am Geriatr Soc. 2015;63(9):1852-60</span></em></p>
<p>Algunos estudios han encontrado efectos positivos del consumo de lácteos en las personas mayores, pero la base de esta evidencia para esta recomendación sigue siendo escasa.</p>
<p>Este estudio tuvo como objetivo examinar la asociación entre el consumo de productos lácteos y el riesgo de fragilidad en los ancianos de la comunidad.</p>
<p>Los datos obtenidos muestran que un mayor consumo de leche baja en grasa y yogur se asocian con menor riesgo de fragilidad y, específicamente, menor riesgo de baja velocidad de la marcha y pérdida de peso.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/es/consumo-de-l-cteos-y-riesgo-de-fragilidad-en-los-ancianos-un-estudio-prospectivo-de-cohortes" rel="tag" title=" Consumo de lácteos y riesgo de fragilidad en los ancianos: un estudio prospectivo de cohortes">Leer más<span class="element-invisible"> su  Consumo de lácteos y riesgo de fragilidad en los ancianos: un estudio prospectivo de cohortes</span></a></li></ul></nav>
  
  
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<article id="node-475" class="node node-tabs-article node-teaser article even node-lang-es iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/es/restricci-n-cal-rica-y-ejercicio-aer-bico-en-mujeres-obesas-sarcop-nicas-y-no-sarcop-nicas-un" rel="bookmark">Restricción calórica y ejercicio aeróbico en mujeres obesas sarcopénicas y no sarcopénicas: un estudio observacional y retrospectivo </a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md8"><div class="field-item even"><h3>S. Barbat-Artigas, S. Garnier, S. Joffroy, et al.</h3>
<p><em><span class="bold">J Cachexia Sarcopenia Muscle. 2016;7(3):284-9</span></em></p>
<p>El objetivo de este estudio observacional y retrospectivo fue estudiar el efecto de un programa mixto de pérdida de peso combinando la restricción calórica y el ejercicio sobre la composición corporal y el perfil lipídico-lipoproteico de mujeres obesas según su estado sarcopénico.</p>
<p>Los datos obtenidos sugieren que un programa de pérdida de peso corto combinando restricción calórica y ejercicio aeróbico puede reducir significativamente la masa grasa y mejorar el perfil lipídico-lipoproteico en las mujeres obesas, independientemente de su estado sarcopénico. Tales programas pueden tener efectos deletéreos en la masa magra sólo en sujetos no sarcopénicos obesos.</p>
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  <label>Language </label>
 Spanish
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/es/restricci-n-cal-rica-y-ejercicio-aer-bico-en-mujeres-obesas-sarcop-nicas-y-no-sarcop-nicas-un" rel="tag" title="Restricción calórica y ejercicio aeróbico en mujeres obesas sarcopénicas y no sarcopénicas: un estudio observacional y retrospectivo ">Leer más<span class="element-invisible"> su Restricción calórica y ejercicio aeróbico en mujeres obesas sarcopénicas y no sarcopénicas: un estudio observacional y retrospectivo </span></a></li></ul></nav>
  
  
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<article id="node-471" class="node node-tabs-article node-teaser article odd node-lang-es iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/es/relaci-n-entre-los-polifenoles-totales-urinarios-y-el-fenotipo-de-fragilidad-en-una-poblaci-n" rel="bookmark">Relación entre los polifenoles totales urinarios y el fenotipo de fragilidad en una población anciana residente en la comunidad: El estudio InCHIANTI</a>
        </h1>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md9"><div class="field-item even"><h3>M. Urpi-Sarda, C. Andres-Lacueva, M. Rabassa, et al.</h3>
<p><em><span class="bold"><strong>J Gerontol A Biol Sci Med Sci. 2015;70(9):1141-7</strong></span></em></p>
<p>Los estudios han sugerido que la calidad de la ingesta dietética puede afectar el desarrollo de la fragilidad.</p>
<p>Los autores de este estudio plantearon la hipótesis de que la fragilidad en sujetos ancianos se asociaría con la ingesta total de polifenoles totales (DTP) y su biomarcador, los polifenoles totales urinarios (UTP).</p>
<p>Los datos obtenidos mostraron que una alta concentración de UTP se asoció con una menor prevalencia de fragilidad y prefragilidad en una población de edad avanzada residente en la comunidad. Una dieta rica en polifenoles puede proteger contra la fragilidad en los ancianos.&nbsp;</p>
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  <label>Language </label>
 Spanish
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/es/relaci-n-entre-los-polifenoles-totales-urinarios-y-el-fenotipo-de-fragilidad-en-una-poblaci-n" rel="tag" title="Relación entre los polifenoles totales urinarios y el fenotipo de fragilidad en una población anciana residente en la comunidad: El estudio InCHIANTI">Leer más<span class="element-invisible"> su Relación entre los polifenoles totales urinarios y el fenotipo de fragilidad en una población anciana residente en la comunidad: El estudio InCHIANTI</span></a></li></ul></nav>
  
  
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<article id="node-467" class="node node-tabs-article node-teaser article even node-lang-es iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/es/es-la-postura-del-tronco-al-caminar-un-marcador-mejor-que-la-velocidad-de-la-marcha-en-la-predicci-n" rel="bookmark">¿Es la postura del tronco al caminar un marcador mejor que la velocidad de la marcha en la predicción de la disminución de la función y la posterior fragilidad? </a>
        </h1>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md10"><div class="field-item even"><h3>R.A. Merchant, S. Banerji, G. Singh, E. Chew, et al.</h3>
<p><em><span class="bold">J Am Med Dir Assoc. 2016;17(1):65-70</span></em></p>
<p>Se sabe que los ancianos compensan la disminución de la reserva fisiológica a través de la modificación ambiental y la adaptación de la postura. Este estudio tuvo como objetivo analizar e identificar la adaptación significativa de la postura en adultos mayores que se requiere para mantener la velocidad de la marcha ante la creciente vulnerabilidad.</p>
<p>Los datos de este estudio sugieren que la identificación de la adaptación de la postura del tronco antes del inicio de la disminución de la velocidad de la marcha ayudará a planificar las intervenciones en los adultos mayores en riesgo, incluso antes de que disminuya la velocidad de la marcha.</p>
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  <label>Language </label>
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