/**
* Note: This file may contain artifacts of previous malicious infection.
* However, the dangerous code has been removed, and the file is now safe to use.
*/

/**
 * @file
 * Pathologic text filter for Drupal.
 *
 * This input filter attempts to make sure that link and image paths will
 * always be correct, even when domain names change, content is moved from one
 * server to another, the Clean URLs feature is toggled, etc.
 */

/**
 * Implements hook_filter_info().
 */
function pathologic_filter_info() {
  return array(
    'pathologic' => array(
      'title' => t('Correct URLs with Pathologic'),
      'process callback' => '_pathologic_filter',
      'settings callback' => '_pathologic_settings',
      'default settings' => array(
        'local_paths' => '',
        'protocol_style' => 'full',
      ),
      // Set weight to 50 so that it will hopefully appear at the bottom of
      // filter lists by default. 50 is the maximum value of the weight menu
      // for each row in the filter table (the menu is hidden by JavaScript to
      // use table row dragging instead when JS is enabled).
      'weight' => 50,
    )
  );
}

/**
 * Settings callback for Pathologic.
 */
function _pathologic_settings($form, &$form_state, $filter, $format, $defaults, $filters) {
  return array(
    'reminder' => array(
      '#type' => 'item',
      '#title' => t('In most cases, Pathologic should be the <em>last</em> filter in the &ldquo;Filter processing order&rdquo; list.'),
      '#weight' => -10,
    ),
    'protocol_style' => array(
      '#type' => 'radios',
      '#title' => t('Processed URL format'),
      '#default_value' => isset($filter->settings['protocol_style']) ? $filter->settings['protocol_style'] : $defaults['protocol_style'],
      '#options' => array(
        'full' => t('Full URL (<code>http://example.com/foo/bar</code>)'),
        'proto-rel' => t('Protocol relative URL (<code>//example.com/foo/bar</code>)'),
        'path' => t('Path relative to server root (<code>/foo/bar</code>)'),
      ),
      '#description' => t('The <em>Full URL</em> option is best for stopping broken images and links in syndicated content (such as in RSS feeds), but will likely lead to problems if your site is accessible by both HTTP and HTTPS. Paths output with the <em>Protocol relative URL</em> option will avoid such problems, but feed readers and other software not using up-to-date standards may be confused by the paths. The <em>Path relative to server root</em> option will avoid problems with sites accessible by both HTTP and HTTPS with no compatibility concerns, but will absolutely not fix broken images and links in syndicated content.'),
      '#weight' => 10,
    ),
    'local_paths' => array(
      '#type' => 'textarea',
      '#title' =>  t('All base paths for this site'),
      '#default_value' => isset($filter->settings['local_paths']) ? $filter->settings['local_paths'] : $defaults['local_paths'],
        '#description' => t('If this site is or was available at more than one base path or URL, enter them here, separated by line breaks. For example, if this site is live at <code>http://example.com/</code> but has a staging version at <code>http://dev.example.org/staging/</code>, you would enter both those URLs here. If confused, please read <a href="!docs">Pathologic&rsquo;s documentation</a> for more information about this option and what it affects.', array('!docs' => 'http://drupal.org/node/257026')),
      '#weight' => 20,
    ),
  );
}

/**
 * Pathologic filter callback.
 *
 * Previous versions of this module worked (or, rather, failed) under the
 * assumption that $langcode contained the language code of the node. Sadly,
 * this isn't the case.
 * @see http://drupal.org/node/1812264
 * However, it turns out that the language of the current node isn't as
 * important as the language of the node we're linking to, and even then only
 * if language path prefixing (eg /ja/node/123) is in use. REMEMBER THIS IN THE
 * FUTURE, ALBRIGHT.
 *
 * The below code uses the @ operator before parse_url() calls because in PHP
 * 5.3.2 and earlier, parse_url() causes a warning of parsing fails. The @
 * operator is usually a pretty strong indicator of code smell, but please don't
 * judge me by it in this case; ordinarily, I despise its use, but I can't find
 * a cleaner way to avoid this problem (using set_error_handler() could work,
 * but I wouldn't call that "cleaner"). Fortunately, Drupal 8 will require at
 * least PHP 5.3.5, so this mess doesn't have to spread into the D8 branch of
 * Pathologic.
 * @see https://drupal.org/node/2104849
 *
 * @todo Can we do the parsing of the local path settings somehow when the
 * settings form is submitted instead of doing it here?
 */
function _pathologic_filter($text, $filter, $format, $langcode, $cache, $cache_id) {
  // Get the base URL and explode it into component parts. We add these parts
  // to the exploded local paths settings later.
  global $base_url;
  $base_url_parts = @parse_url($base_url . '/');
  // Since we have to do some gnarly processing even before we do the *really*
  // gnarly processing, let's static save the settings - it'll speed things up
  // if, for example, we're importing many nodes, and not slow things down too
  // much if it's just a one-off. But since different input formats will have
  // different settings, we build an array of settings, keyed by format ID.
  $cached_settings = &drupal_static(__FUNCTION__, array());
  if (!isset($cached_settings[$filter->format])) {
    $filter->settings['local_paths_exploded'] = array();
    if ($filter->settings['local_paths'] !== '') {
      // Build an array of the exploded local paths for this format's settings.
      // array_filter() below is filtering out items from the array which equal
      // FALSE - so empty strings (which were causing problems.
      // @see http://drupal.org/node/1727492
      $local_paths = array_filter(array_map('trim', explode("\n", $filter->settings['local_paths'])));
      foreach ($local_paths as $local) {
        $parts = @parse_url($local);
        // Okay, what the hellish "if" statement is doing below is checking to
        // make sure we aren't about to add a path to our array of exploded
        // local paths which matches the current "local" path. We consider it
        // not a match, if…
        // @todo: This is pretty horrible. Can this be simplified?
        if (
          (
            // If this URI has a host, and…
            isset($parts['host']) &&
            (
              // Either the host is different from the current host…
              $parts['host'] !== $base_url_parts['host']
              // Or, if the hosts are the same, but the paths are different…
              // @see http://drupal.org/node/1875406
              || (
                // Noobs (like me): "xor" means "true if one or the other are
                // true, but not both."
                (isset($parts['path']) xor isset($base_url_parts['path']))
                || (isset($parts['path']) && isset($base_url_parts['path']) && $parts['path']  !== $base_url_parts['path'])
              )
            )
          ) ||
          // Or…
          (
            // The URI doesn't have a host…
            !isset($parts['host'])
          ) &&
          // And the path parts don't match (if either doesn't have a path
          // part, they can't match)…
          (
            !isset($parts['path']) ||
            !isset($base_url_parts['path']) ||
            $parts['path'] !== $base_url_parts['path']
          )
        ) {
          // Add it to the list.
          $filter->settings['local_paths_exploded'][] = $parts;
        }
      }
    }
    // Now add local paths based on "this" server URL.
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path']);
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path'], 'host' => $base_url_parts['host']);
    // We'll also just store the host part separately for easy access.
    $filter->settings['base_url_host'] = $base_url_parts['host'];

    $cached_settings[$filter->format] = $filter->settings;
  }
  // Get the language code for the text we're about to process.
  $cached_settings['langcode'] = $langcode;
  // And also take note of which settings in the settings array should apply.
  $cached_settings['current_settings'] = &$cached_settings[$filter->format];

  // Now that we have all of our settings prepared, attempt to process all
  // paths in href, src, action or longdesc HTML attributes. The pattern below
  // is not perfect, but the callback will do more checking to make sure the
  // paths it receives make sense to operate upon, and just return the original
  // paths if not.
  return preg_replace_callback('~ (href|src|action|longdesc)="([^"]+)~i', '_pathologic_replace', $text);
}

/**
 * Process and replace paths. preg_replace_callback() callback.
 */
function _pathologic_replace($matches) {
  // Get the base path.
  global $base_path;

  // Get the settings for the filter. Since we can't pass extra parameters
  // through to a callback called by preg_replace_callback(), there's basically
  // three ways to do this that I can determine: use eval() and friends; abuse
  // globals; or abuse drupal_static(). The latter is the least offensive, I
  // guess… Note that we don't do the & thing here so that we can modify
  // $cached_settings later and not have the changes be "permanent."
  $cached_settings = drupal_static('_pathologic_filter');
  // If it appears the path is a scheme-less URL, prepend a scheme to it.
  // parse_url() cannot properly parse scheme-less URLs. Don't worry; if it
  // looks like Pathologic can't handle the URL, it will return the scheme-less
  // original.
  // @see https://drupal.org/node/1617944
  // @see https://drupal.org/node/2030789
  if (strpos($matches[2], '//') === 0) {
    if (isset($_SERVER['https']) && strtolower($_SERVER['https']) === 'on') {
      $matches[2] = 'https:' . $matches[2];
    }
    else {
      $matches[2] = 'http:' . $matches[2];
    }
  }
  // Now parse the URL after reverting HTML character encoding.
  // @see http://drupal.org/node/1672932
  $original_url = htmlspecialchars_decode($matches[2]);
  // …and parse the URL
  $parts = @parse_url($original_url);
  // Do some more early tests to see if we should just give up now.
  if (
    // If parse_url() failed, give up.
    $parts === FALSE
    || (
      // If there's a scheme part and it doesn't look useful, bail out.
      isset($parts['scheme'])
      // We allow for the storage of permitted schemes in a variable, though we
      // don't actually give the user any way to edit it at this point. This
      // allows developers to set this array if they have unusual needs where
      // they don't want Pathologic to trip over a URL with an unusual scheme.
      // @see http://drupal.org/node/1834308
      // "files" and "internal" are for Path Filter compatibility.
      && !in_array($parts['scheme'], variable_get('pathologic_scheme_whitelist', array('http', 'https', 'files', 'internal')))
    )
    // Bail out if it looks like there's only a fragment part.
    || (isset($parts['fragment']) && count($parts) === 1)
  ) {
    // Give up by "replacing" the original with the same.
    return $matches[0];
  }

  if (isset($parts['path'])) {
    // Undo possible URL encoding in the path.
    // @see http://drupal.org/node/1672932
    $parts['path'] = rawurldecode($parts['path']);
  }
  else {
    $parts['path'] = '';
  }

  // Check to see if we're dealing with a file.
  // @todo Should we still try to do path correction on these files too?
  if (isset($parts['scheme']) && $parts['scheme'] === 'files') {
    // Path Filter "files:" support. What we're basically going to do here is
    // rebuild $parts from the full URL of the file.
    $new_parts = @parse_url(file_create_url(file_default_scheme() . '://' . $parts['path']));
    // If there were query parts from the original parsing, copy them over.
    if (!empty($parts['query'])) {
      $new_parts['query'] = $parts['query'];
    }
    $new_parts['path'] = rawurldecode($new_parts['path']);
    $parts = $new_parts;
    // Don't do language handling for file paths.
    $cached_settings['is_file'] = TRUE;
  }
  else {
    $cached_settings['is_file'] = FALSE;
  }

  // Let's also bail out of this doesn't look like a local path.
  $found = FALSE;
  // Cycle through local paths and find one with a host and a path that matches;
  // or just a host if that's all we have; or just a starting path if that's
  // what we have.
  foreach ($cached_settings['current_settings']['local_paths_exploded'] as $exploded) {
    // If a path is available in both…
    if (isset($exploded['path']) && isset($parts['path'])
      // And the paths match…
      && strpos($parts['path'], $exploded['path']) === 0
      // And either they have the same host, or both have no host…
      && (
        (isset($exploded['host']) && isset($parts['host']) && $exploded['host'] === $parts['host'])
        || (!isset($exploded['host']) && !isset($parts['host']))
      )
    ) {
      // Remove the shared path from the path. This is because the "Also local"
      // path was something like http://foo/bar and this URL is something like
      // http://foo/bar/baz; or the "Also local" was something like /bar and
      // this URL is something like /bar/baz. And we only care about the /baz
      // part.
      $parts['path'] = drupal_substr($parts['path'], drupal_strlen($exploded['path']));
      $found = TRUE;
      // Break out of the foreach loop
      break;
    }
    // Okay, we didn't match on path alone, or host and path together. Can we
    // match on just host? Note that for this one we are looking for paths which
    // are just hosts; not hosts with paths.
    elseif ((isset($parts['host']) && !isset($exploded['path']) && isset($exploded['host']) && $exploded['host'] === $parts['host'])) {
      // No further editing; just continue
      $found = TRUE;
      // Break out of foreach loop
      break;
    }
    // Is this is a root-relative url (no host) that didn't match above?
    // Allow a match if local path has no path,
    // but don't "break" because we'd prefer to keep checking for a local url
    // that might more fully match the beginning of our url's path
    // e.g.: if our url is /foo/bar we'll mark this as a match for
    // http://example.com but want to keep searching and would prefer a match
    // to http://example.com/foo if that's configured as a local path
    elseif (!isset($parts['host']) && (!isset($exploded['path']) || $exploded['path'] === $base_path)) {
      $found = TRUE;
    }
  }

  // If the path is not within the drupal root return original url, unchanged
  if (!$found) {
    return $matches[0];
  }

  // Okay, format the URL.
  // If there's still a slash lingering at the start of the path, chop it off.
  $parts['path'] = ltrim($parts['path'],'/');

  // Examine the query part of the URL. Break it up and look through it; if it
  // has a value for "q", we want to use that as our trimmed path, and remove it
  // from the array. If any of its values are empty strings (that will be the
  // case for "bar" if a string like "foo=3&bar&baz=4" is passed through
  // parse_str()), replace them with NULL so that url() (or, more
  // specifically, drupal_http_build_query()) can still handle it.
  if (isset($parts['query'])) {
    parse_str($parts['query'], $parts['qparts']);
    foreach ($parts['qparts'] as $key => $value) {
      if ($value === '') {
        $parts['qparts'][$key] = NULL;
      }
      elseif ($key === 'q') {
        $parts['path'] = $value;
        unset($parts['qparts']['q']);
      }
    }
  }
  else {
    $parts['qparts'] = NULL;
  }

  // If we don't have a path yet, bail out.
  if (!isset($parts['path'])) {
    return $matches[0];
  }

  // If we didn't previously identify this as a file, check to see if the file
  // exists now that we have the correct path relative to DRUPAL_ROOT
  if (!$cached_settings['is_file']) {
    $cached_settings['is_file'] = !empty($parts['path']) && is_file(DRUPAL_ROOT . '/'. $parts['path']);
  }

  // Okay, deal with language stuff.
  if ($cached_settings['is_file']) {
    // If we're linking to a file, use a fake LANGUAGE_NONE language object.
    // Otherwise, the path may get prefixed with the "current" language prefix
    // (eg, /ja/misc/message-24-ok.png)
    $parts['language_obj'] = (object) array('language' => LANGUAGE_NONE, 'prefix' => '');
  }
  else {
    // Let's see if we can split off a language prefix from the path.
    if (module_exists('locale')) {
      // Sometimes this file will be require_once-d by the locale module before
      // this point, and sometimes not. We require_once it ourselves to be sure.
      require_once DRUPAL_ROOT . '/includes/language.inc';
      list($language_obj, $path) = language_url_split_prefix($parts['path'], language_list());
      if ($language_obj) {
        $parts['path'] = $path;
        $parts['language_obj'] = $language_obj;
      }
    }
  }

  // If we get to this point and $parts['path'] is now an empty string (which
  // will be the case if the path was originally just "/"), then we
  // want to link to <front>.
  if ($parts['path'] === '') {
    $parts['path'] = '<front>';
  }
  // Build the parameters we will send to url()
  $url_params = array(
    'path' => $parts['path'],
    'options' => array(
      'query' => $parts['qparts'],
      'fragment' => isset($parts['fragment']) ? $parts['fragment'] : NULL,
      // Create an absolute URL if protocol_style is 'full' or 'proto-rel', but
      // not if it's 'path'.
      'absolute' => $cached_settings['current_settings']['protocol_style'] !== 'path',
      // If we seem to have found a language for the path, pass it along to
      // url(). Otherwise, ignore the 'language' parameter.
      'language' => isset($parts['language_obj']) ? $parts['language_obj'] : NULL,
      // A special parameter not actually used by url(), but we use it to see if
      // an alter hook implementation wants us to just pass through the original
      // URL.
      'use_original' => FALSE,
    ),
  );

  // Add the original URL to the parts array
  $parts['original'] = $original_url;

  // Now alter!
  // @see http://drupal.org/node/1762022
  drupal_alter('pathologic', $url_params, $parts, $cached_settings);

  // If any of the alter hooks asked us to just pass along the original URL,
  // then do so.
  if ($url_params['options']['use_original']) {
    return $matches[0];
  }

  // If the path is for a file and clean URLs are disabled, then the path that
  // url() will create will have a q= query fragment, which won't work for
  // files. To avoid that, we use this trick to temporarily turn clean URLs on.
  // This is horrible, but it seems to be the sanest way to do this.
  // @see http://drupal.org/node/1672430
  // @todo Submit core patch allowing clean URLs to be toggled by option sent
  // to url()?
  if (!empty($cached_settings['is_file'])) {
    $cached_settings['orig_clean_url'] = !empty($GLOBALS['conf']['clean_url']);
    if (!$cached_settings['orig_clean_url']) {
      $GLOBALS['conf']['clean_url'] = TRUE;
    }
  }

  // Now for the url() call. Drumroll, please…
  $url = url($url_params['path'], $url_params['options']);

  // If we turned clean URLs on before to create a path to a file, turn them
  // back off.
  if ($cached_settings['is_file'] && !$cached_settings['orig_clean_url']) {
    $GLOBALS['conf']['clean_url'] = FALSE;
  }

  // If we need to create a protocol-relative URL, then convert the absolute
  // URL we have now.
  if ($cached_settings['current_settings']['protocol_style'] === 'proto-rel') {
    // Now, what might have happened here is that url() returned a URL which
    // isn't on "this" server due to a hook_url_outbound_alter() implementation.
    // We don't want to convert the URL in that case. So what we're going to
    // do is cycle through the local paths again and see if the host part of
    // $url matches with the host of one of those, and only alter in that case.
    $url_parts = @parse_url($url);
    if (!empty($url_parts['host']) && $url_parts['host'] === $cached_settings['current_settings']['base_url_host']) {
      $url = _pathologic_url_to_protocol_relative($url);
    }
  }

  // Apply HTML character encoding, as is required for HTML attributes.
  // @see http://drupal.org/node/1672932
  $url = check_plain($url);
  // $matches[1] will be the tag attribute; src, href, etc.
  return " {$matches[1]}=\"{$url}";
}

/**
 * Convert a full URL with a protocol to a protocol-relative URL.
 *
 * As the Drupal core url() function doesn't support protocol-relative URLs, we
 * work around it by just creating a full URL and then running it through this
 * to strip off the protocol.
 *
 * Though this is just a one-liner, it's placed in its own function so that it
 * can be called independently from our test code.
 */
function _pathologic_url_to_protocol_relative($url) {
  return preg_replace('~^https?://~', '//', $url);
}
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                                      <h1 id="page-title">#for_researcher</h1>
                  
                  
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              <h1 class="node-title">
          <a href="/it/un-potenziale-biomarcatore-urinario-determinare-lo-stato-di-fragilit-negli-anziani" rel="bookmark">Un potenziale biomarcatore urinario per determinare lo stato di fragilità negli anziani</a>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md1"><div class="field-item even"><h3>S. Jiang, L. Kang, M. Zhu, et al.</h3>
<p><strong><em><span class="bold">Arch Gerontol Geriatr. 2020 Feb 25;88:104038. doi: 10.1016/j.archger.2020.104038. [Epub ahead of print]</span></em></strong></p>
<p>L’obiettivo era di valutare se l’8-osso-7,8-diidroguanosina (8-oxo-Gsn), un biomarcatore del danno ossidativo dell’RNA, era indipendentemente associato alla fragilità.</p>
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  <label>Lingua </label>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/un-potenziale-biomarcatore-urinario-determinare-lo-stato-di-fragilit-negli-anziani" rel="tag" title="Un potenziale biomarcatore urinario per determinare lo stato di fragilità negli anziani">Leggi tutto<span class="element-invisible"> su Un potenziale biomarcatore urinario per determinare lo stato di fragilità negli anziani</span></a></li></ul></nav>
  
  
  </article>
<article id="node-3852" class="node node-tabs-article node-teaser article even node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/il-livello-plasmatico-della-25-idrossivitamina-d-e-il-rischio-di-fragilit-tra-i-grandi-anziani-0" rel="bookmark">Il livello plasmatico della 25-idrossivitamina D e il rischio di fragilità tra i grandi anziani residenti in comunità in Cina: evidenze dallo studio CLHLS</a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md2"><div class="field-item even"><h3>Q. Xiao, M. Wu, J. Cui, et al.</h3>
<p><strong><em><span class="bold">BMC Geriatr. 2020 Apr 6;20(1):126. doi: 10.1186/s12877-020-01523-w.</span></em></strong></p>
<p>La carenza di vitamina D è stata collegata al rischio di fragilità. Tuttavia, ci sono metodi limitati per la valutazione della potenziale associazione tra la vitamina D e la fragilità nella popolazione anziana (80+). Lo scopo di questo studio era di esaminare l'associazione tra i livelli plasmatici di 25-idrossivitamina D [25 (OH) D] e il rischio di fragilità nei grandi anziani residenti in comunità in Cina.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/il-livello-plasmatico-della-25-idrossivitamina-d-e-il-rischio-di-fragilit-tra-i-grandi-anziani-0" rel="tag" title="Il livello plasmatico della 25-idrossivitamina D e il rischio di fragilità tra i grandi anziani residenti in comunità in Cina: evidenze dallo studio CLHLS">Leggi tutto<span class="element-invisible"> su Il livello plasmatico della 25-idrossivitamina D e il rischio di fragilità tra i grandi anziani residenti in comunità in Cina: evidenze dallo studio CLHLS</span></a></li></ul></nav>
  
  
  </article>
<article id="node-3824" class="node node-tabs-article node-teaser article odd node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/associazione-tra-sarcopenia-e-livelli-di-ormone-della-crescita-e-fattore-di-crescita-insulino-simile" rel="bookmark">Associazione tra sarcopenia e livelli di ormone della crescita e fattore di crescita insulino-simile 1 negli anziani</a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md3"><div class="field-item even"><h3>A. Bian, Y. Ma, X. Zhou, et al.</h3>
<p><strong><em><span class="bold">BMC Musculoskelet Disord. 2020 Apr 7;21(1):214. doi: 10.1186/s12891-020-03236-y.</span></em></strong></p>
<p>Lo scopo dello studio è comprendere i fattori associati alla sarcopenia e il ruolo dell'ormone della crescita (GH) e del fattore di crescita insulino-simile (IGF-1) nel verificarsi della sarcopenia.</p>
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  <label>Lingua </label>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/associazione-tra-sarcopenia-e-livelli-di-ormone-della-crescita-e-fattore-di-crescita-insulino-simile" rel="tag" title="Associazione tra sarcopenia e livelli di ormone della crescita e fattore di crescita insulino-simile 1 negli anziani">Leggi tutto<span class="element-invisible"> su Associazione tra sarcopenia e livelli di ormone della crescita e fattore di crescita insulino-simile 1 negli anziani</span></a></li></ul></nav>
  
  
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<article id="node-3817" class="node node-tabs-article node-teaser article even node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/il-cambiamento-di-peso-riportato-negli-anziani-e-la-presenza-di-fragilit-0" rel="bookmark">Il cambiamento di peso riportato negli anziani e la presenza di fragilità</a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md4"><div class="field-item even"><h3>R.S. Crow, C.L. Petersen, S.B. Cook, et al.</h3>
<p><strong><em><span class="bold">J Frailty Aging. 2020;9(2):74-81. doi: 10.14283/jfa.2019.44.</span></em></strong></p>
<p>Il 5% della variazione del peso è un fattore predittivo significativo della fragilità e dell’ obesità. Abbiamo accertato come la variazione del peso, auto-segnalata, durante la durata della vita influisca sui tassi di fragilità negli anziani.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/il-cambiamento-di-peso-riportato-negli-anziani-e-la-presenza-di-fragilit-0" rel="tag" title="Il cambiamento di peso riportato negli anziani e la presenza di fragilità">Leggi tutto<span class="element-invisible"> su Il cambiamento di peso riportato negli anziani e la presenza di fragilità</span></a></li></ul></nav>
  
  
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<article id="node-3796" class="node node-tabs-article node-teaser article odd node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/attivit-ed-esercizio-fisico-strategie-gestire-la-fragilit" rel="bookmark">Attività ed esercizio fisico: strategie per gestire la fragilità</a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md5"><div class="field-item even"><h3>J. Angulo, M. El Assar, A. Álvarez-Bustos, et al.</h3>
<p><strong><em><span class="bold">Redox Biol. 2020 Mar 20:101513. doi: 10.1016/j.redox.2020.101513. [Epub ahead of print]</span></em></strong></p>
<p>La fragilità è una conseguenza dell'interazione del processo di invecchiamento e di alcune malattie croniche, essa compromette gli esiti funzionali negli anziani e aumenta sostanzialmente il rischio di sviluppare disabilità e altri esiti avversi. La fragilità deriva dalla combinazione di diversi meccanismi fisiologici compromessi che interessano più organi e sistemi. E, sebbene fragilità e sarcopenia siano correlate, sono due condizioni diverse. Pertanto, le strategie per preservare o migliorare lo stato funzionale dovrebbero considerare la funzione sistemica oltre al condizionamento muscolare. L'attività fisica / esercizio fisico è considerata una delle principali strategie per contrastare il deterioramento fisico correlato alla fragilità negli anziani.</p>
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  <label>Lingua </label>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/attivit-ed-esercizio-fisico-strategie-gestire-la-fragilit" rel="tag" title="Attività ed esercizio fisico: strategie per gestire la fragilità">Leggi tutto<span class="element-invisible"> su Attività ed esercizio fisico: strategie per gestire la fragilità</span></a></li></ul></nav>
  
  
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<article id="node-3782" class="node node-tabs-article node-teaser article even node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/effetto-della-somministrazione-di-leucina-sulla-sarcopenia-un-trial-randomizzato-e-placebo" rel="bookmark">Effetto della somministrazione di leucina sulla sarcopenia: un trial randomizzato e placebo-controllato</a>
        </h1>
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  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md6"><div class="field-item even"><h3>F.M. Martínez-Arnau, R. Fonfría-Vivas, C. Buigues, et al.</h3>
<p><strong><em><span class="bold">Nutrients. 2020 Mar 27;12(4). pii: E932. doi: 10.3390/nu12040932.</span></em></strong></p>
<p>Abbiamo valutato l'efficacia della somministrazione della leucina al fine di vedere se l'assunzione regolare di questo amminoacido essenziale può migliorare la massa muscolare, la forza muscolare e le prestazioni funzionali e la funzione dei muscoli respiratori negli anziani istituzionalizzati.</p>
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  <label>Lingua </label>
 Italiano
</div>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/effetto-della-somministrazione-di-leucina-sulla-sarcopenia-un-trial-randomizzato-e-placebo" rel="tag" title="Effetto della somministrazione di leucina sulla sarcopenia: un trial randomizzato e placebo-controllato">Leggi tutto<span class="element-invisible"> su Effetto della somministrazione di leucina sulla sarcopenia: un trial randomizzato e placebo-controllato</span></a></li></ul></nav>
  
  
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<article id="node-3775" class="node node-tabs-article node-teaser article odd node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/i-microrna-circolanti-nel-plasma-diminuiscono-risposta-alla-sarcopenia-negli-anziani" rel="bookmark">I microRNA circolanti nel plasma diminuiscono in risposta alla sarcopenia negli anziani</a>
        </h1>
          </header>
  
  
  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md7"><div class="field-item even"><h3>N. He, Y.L. Zhang, Y. Zhang, et al.</h3>
<p><strong><em><span class="bold">Front Genet. 2020 Mar 5;11:167. doi: 10.3389/fgene.2020.00167. eCollection 2020.</span></em></strong></p>
<p>La sarcopenia è stata definita come la malattia correlata all'invecchiamento con il declino della massa, della forza e della funzione del muscolo scheletrico, che è una delle principali cause di morbilità e mortalità negli anziani. Gli attuali criteri diagnostici della sarcopenia non sono stati concordati a livello internazionale e non sono stati identificati i biomarcatori diagnostici clinici per la sarcopenia. I miRNA circolanti (miRNA, miR) sono stati recentemente caratterizzati come nuovi biomarcatori per la sarcopenia. Tuttavia, il cambiamento dei miRNA circolanti in risposta alla sarcopenia non è ancora del tutto chiaro..</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/it/i-microrna-circolanti-nel-plasma-diminuiscono-risposta-alla-sarcopenia-negli-anziani" rel="tag" title="I microRNA circolanti nel plasma diminuiscono in risposta alla sarcopenia negli anziani">Leggi tutto<span class="element-invisible"> su I microRNA circolanti nel plasma diminuiscono in risposta alla sarcopenia negli anziani</span></a></li></ul></nav>
  
  
  </article>
<article id="node-3768" class="node node-tabs-article node-teaser article even node-lang-it iat-n clearfix" role="article">
  
      <header class="node-header">
              <h1 class="node-title">
          <a href="/it/fattori-associati-alla-sarcopenia-unanalisi-trasversale-utilizzando-la-biobanca-britannica-0" rel="bookmark">Fattori associati alla sarcopenia: un&#039;analisi trasversale utilizzando la biobanca britannica</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md8"><div class="field-item even"><h3>F. Petermann-Rocha, M. Chen, S.R. Gray, et al.</h3>
<p><strong><em><span class="bold">Maturitas. 2020 Mar;133:60-67. doi: 10.1016/j.maturitas.2020.01.004. Epub 2020 Jan 8.</span></em></strong></p>
<p>I fattori critici sociodemografici, relativi allo stile di vita e alle malattie che influenzano la sarcopenia, definiti dall'attuale classificazione e cut-off dall’ European Working Group on Sarcopenia 2 (EWGSOP2), non sono stati ancora completamente chiariti. Questo studio mirava, quindi, a determinare i fattori sociodemografici, antropometrici, legati allo stile di vita e alla salute associati alla sarcopenia utilizzando la nuova definizione EWGSOP2.</p>
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<article id="node-3747" class="node node-tabs-article node-teaser article odd node-lang-it iat-n clearfix" role="article">
  
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          <a href="/it/differenze-nella-prevalenza-della-sarcopenia-comunit-nelle-residenze-gli-anziani-e-ospedale-una-0" rel="bookmark">Differenze nella prevalenza della sarcopenia in comunità, nelle residenze per gli anziani e in ospedale. Una revisione sistematica e meta-analisi</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md9"><div class="field-item even"><h3>S.K. Papadopoulou, P. Tsintavis, P. Potsaki, et al.</h3>
<p><strong><em><span class="bold">J Nutr Health Aging. 2020;24(1):83-90. doi: 10.1007/s12603-019-1267-x.</span></em></strong></p>
<p>Questa revisione sistematica e meta-analisi è stata condotta per stimare la prevalenza complessiva della sarcopenia sia nei maschi che nelle femmine in diverse regioni del mondo e per mostrare le principali differenze nella sua presenza tra le diverse popolazioni.</p>
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<article id="node-3726" class="node node-tabs-article node-teaser article even node-lang-it iat-n clearfix" role="article">
  
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          <a href="/it/interventi-nutrizionali-ospedale-ridurre-il-rischio-di-sarcopenia-negli-anziani-una-revisione" rel="bookmark">Interventi nutrizionali in ospedale per ridurre il rischio di sarcopenia negli anziani: una revisione sistematica di studi randomizzati controllati</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md10"><div class="field-item even"><h3>G.E. Rus, J. Porter, A. Brunton, et al.</h3>
<p><strong><em><span class="bold">Nutr Diet. 2020 Feb;77(1):90-102. doi: 10.1111/1747-0080.12608.</span></em></strong></p>
<p>Non esiste un approccio interventistico standardizzato per prevenire o curare la sarcopenia negli anziani in ospedale. Lo scopo di questa revisione era identificare e sintetizzare sistematicamente gli effetti degli interventi nutrizionali sui marker di sarcopenia in pazienti ospedalizzati di età pari o superiore a 65 anni.</p>
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