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Nutritional, Physical, Cognitive and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial

T. P. Ng, L. Feng, M.S. Nyunt, et al.

Am J Med.2015;128:1225-1236.e1

This study aimed to assess the reversibility of frailty in 246 community-living prefrail and frail older people in Singapore (mean age: 70 years). Participants were randomly assigned to 5 different 6-month interventions: nutritional supplementation, physical training, cognitive training, combination treatment and usual care control. Frailty score, body mass index, knee extension strength, gait speed, energy/vitality, physical activity levels and secondary outcomes (activities of daily living dependency, hospitalization and falls) were assessed at 0, 3, 6 and 12 months.

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Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial

J.M. Bauer, S. Verlaan, I. Bautmans, et al.

J Am Med Dir Assoc.2015;16:740-747

This study was a multicenter, randomized, controlled, double-blind, 2 parallel-group trial among 380 sarcopenic primarily independent-living older adults. The aim of the study was to test the hypothesis that a specific oral nutritional supplement can result in improvements in measures of sarcopenia. Improvements in muscle mass and lower-extremity function were observed, suggesting that nutritional supplementation alone might benefit geriatric patients.

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Estimation of sarcopenia prevalence using various assessment tools

C. Beaudart, J.Y. Reginster, J. Slomian, et al.

Experimental Gerontology.2015;61:31-7

This study aims to evaluate the prevalence of sarcopenia in relation to the assessment tool used in the measurement of the variables related to muscle mass, muscle strength and physical performance. The results obtained showed that the prevalence of sarcopenia varies between 8.4% and 27.6% in relation to the method used. Furthermore, it was observed that the bioelectrical impedance analysis (BIA) tends to overestimate muscle mass compared to the X-ray absorptiometry dual energy (DXA). As regards the muscle strength, it is observed that the pneumatic dynamometer allowed to diagnose the double of the sarcopenic subjects compared to hydraulic dynamometer.

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Prevalence and risk factors of sarcopenia among adults living in nursing homes

H. E. Senior, T. R. Henwood, E. M. Beller, et al.

Maturitas 2015; 82: 418–423

Sarcopenia is a progressive loss of skeletal muscle and muscle function, with significant health and disability consequences for older adults. This study was aimed to evaluate the prevalence and risk factors of sarcopenia among older residential aged care adults using the European Working Group on Sarcopenia in Older People (EWGSOP) criteria.

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The impact of sleep on age-related sarcopenia: Possible connections and clinical implications

R.D. Piovezan, J. Abucham, R.V. Dos Santos, et al.

Ageing Res Rev. 2015 ;23(Pt B):210-20

Reductions in duration and quality of sleep and increases in prevalence of circadian rhythm and sleep disorders with age favor proteolysis, modify body composition and increase the risk of insulin resistance, all of which have been associated with sarcopenia. Therapeutic approaches targeting sleep disturbances to normalize circadian rhythms and sleep homeostasis may represent a novel strategy to preserve or recover muscle health in older adults.

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Energetics of Aging and Frailty: The FRADEA Study

P. Abizanda, L. Romero, P.M. Sánchez-Jurado, et al.

J Gerontol A Biol Sci Med Sci. 2016;71(6):787-96

Resting metabolic rate (RMR) and total daily energy expenditure (TDEE) decrease with aging, but it is not known whether frailty modulates this association. Authors hypothesize that RMR and TDEE values are similar between younger and older nonfrail adults, whereas they are lower in older prefrail and frail compared with younger adults. This study shows that frailty status modulates the energy requirements of aging. Frail and prefrail older adults present lower eRMR than nonfrail adults.

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Dairy Consumption and Risk of Frailty in Older Adults: A Prospective Cohort Study

A. Lana, F. Rodriguez-Artalejo and E. Lopez-Garcia

J Am Geriatr Soc. 2015;63(9):1852-60

Some studies have found positive effects of dairy consumption in older people, but the evidence base for this recommendation remains scarce. This study aimed to examining the association between consumption of dairy products and risk of frailty in community-dwelling older adults. Data obtained shown that higher consumption of low-fat milk and yogurt are associated with lower risk of frailty and, specifically, lower risk of slow walking speed and weight loss.

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Association of Hearing Impairment With Incident Frailty and Falls in Older Adults

R.J. Kamil, J. Betz, B. Brott Powers, et al.

Journal of Aging and Health.2016;28(4):644-60

The hearing impairment (HI) is highly prevalent but undertreated in older adults and, although it contributes to frailty risk, it remains poorly studied. This study aimed at determining whether HI in older adults is associated with the development of frailty and falls. This study demonstrate that moderate or greater HI is associated with increased risk of developing frailty and that HI is associated with an increased annual risk of falling.

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Accelerometer-determined physical activity, muscle mass, and leg strength in community-dwelling older adults

Y.C. Foong, N. Chherawala, D. Aitken, et al.

J Cachexia Sarcopenia Muscle. 2015;7(3):275-83

The aim of this study was to describe the relationship between accelerometer-determined physical activity (PA), muscle mass, and lower-limb strength in community-dwelling older adults. Using accelerometer technology, both the amount and intensity of accelerometer-determined PA had an independent, dose-response relationship with lean mass percentage and lower limb strength, with the largest effect for vigorous activity. Time spent in sedentary activity was negatively associated with lean mass percentage, but was not associated with lower limb strength. The magnitude of the association between PA and lean mass percentage decreased with age.

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Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study

M. Rabassa, R. Zamora-Ros, M. Urpi-Sarda, et al.

Am J Clin Nutr. 2015;102:1534–42

Resveratrol may play a protective role against the frailty syndrome (FS) because of its antioxidant and anti-inflammatory properties. This study has prospectively evaluated the association between habitual dietary resveratrol exposure and the development of FS after 3-, 6-, and 9-years follow-up periods in a community-dwelling older population. This study has shown that higher habitual dietary resveratrol exposure was associated with lower risk of older community dwellers developing FS during the first 3 years of follow-up but not after longer follow-up periods.

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