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SARC-F for sarcopenia screening in community-dwelling older adults: Are 3 items enough?

M. Yang, X. Hu, L. Xie, et al.

Medicine (Baltimore). 2018;97(30):e11726

A 3-item SARC-F (termed SARC-F-3 in our study) was recently suggested as a screening tool for sarcopenia.

The aim of this study was to compare the diagnostic value of SARC-F-3 to SARC-F in community-dwelling older people.

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The age-related loss of skeletal muscle mass and function: measurement and mechanisms of muscle fibre atrophy and muscle fibre loss in humans

D.J. Wilkinson, M. Piasecki and P.J. Atherton

Ageing Res Rev. 2018;47:123-132

This review will focus on muscle deterioration with ageing and highlight the two underpinning mechanisms regulating declines in muscle mass and function: muscle fibre atrophy and muscle fibre loss (hypoplasia) - and their measurement.

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Cholecalciferol or 25-Hydroxycholecalciferol Supplementation Does Not Affect Muscle Strength and Physical Performance in Prefrail and Frail Older Adults

A.M.M. Vaes, M. Tieland, N. Toussaint, et al.

J Nutr. 2018;148(5):712-720

Vitamin D supplementation is proposed as a potential treatment strategy to counteract functional decline in older adults. However, data from randomized trials are either limited or inconsistent.

This study investigated the effect of daily supplementation with 25-hydroxycholecalciferol [25(OH)D3] or cholecalciferol (vitamin D3) on muscle strength and physical performance in older adults.

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Validation of the sarcopenia index to assess muscle mass in the critically ill: A novel application of kidney function markers

E.F. Barreto, J.O. Poyant, H.H. Coville, et al.

Clin Nutr. 2018 Jun 8. pii: S0261-5614(18)30218-8. doi: 10.1016/j.clnu.2018.05.031. [Epub ahead of print]

Adverse outcomes for hospitalized patients with sarcopenia are well documented, and identification of patients at risk remains challenging. The sarcopenia index (SI), previously defined as (serum creatinine/serum cystatin C) × 100, could be an inexpensive, readily accessible, objective tool to predict muscle mass and risk for adverse clinical outcomes. The aim of this study was to assess the validity of the SI as a predictor of muscle mass

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What is the duration of life expectancy in the state of frailty? Estimates in the SIPAF study

M. Herr, J.J. Arvieu, J. Ankri, et al.

Eur J Ageing. 2017;15(2):165-173

This study aimed to estimate the time spent in the state of frailty in men and women using the Sullivan method.

In conclusion, frailty is a transition state that is relatively limited in time compared to pre-frailty that may represent a larger time window for prevention.  

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The frail older person does not exist: development of frailty profiles with latent class analysis

W.M. Looman, I.N. Fabbricotti, J.W. Blom, et al.

BMC Geriatr. 2018;18(1):84

The heterogeneous population of frail older people has differing needs and faces different health issues that should be considered to tailor care interventions.

Evaluation research of these interventions should acknowledge the heterogeneity of frailty by profiling.  

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Association between Sarcopenia and Metabolic Syndrome in Middle-Aged and Older Non-Obese Adults: A Systematic Review and Meta-Analysis

H. Zhang, S. Lin, T. Gao, et al.

Nutrients. 2018 Mar 16;10(3). pii: E364. doi: 10.3390/nu10030364

Our study revealed that a higher proportion of metabolic syndrome (MetS) in middle-aged and older non-obese people with sarcopenia.

Moreover, sarcopenia was positively associated with MetS in this population. Further large-scale prospective cohort studies are needed to investigate the causality between sarcopenia and MetS.

 

 

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SARC-F for Screening of Sarcopenia Among Older Adults: A Meta-analysis of Screening Test Accuracy

S. Ida, R. Kaneko, K. Murata

J Am Med Dir Assoc. 2018 May 16. pii: S1525-8610(18)30153-1. doi: 10.1016/j.jamda.2018.04.001. [Epub ahead of print]

Although the screening sensitivity performance of SARC-F was poor, its specificity was high; thus, it is an effective tool for selecting subjects who should undergo further testing for confirming a diagnosis of sarcopenia.

 

 

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