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Serum markers of inflammation and oxidative stress in sarcopenia

B. Can, O. Kara, M.C. Kizilarslanoglu, et al.

Aging Clin Exp Res. 2017;29(4):745-752

The aim of the study was to evaluate the relationship between sarcopenia and biomarkers that may be involved in its pathogenesis and hence allow early detection. The present study demonstrated an association of sarcopenia with inflammatory markers CRP, erythrocyte sedimentation rate and adiponectin.

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Emergency general surgery specific frailty index: A validation study

T.O. Jokar, K. Ibraheem, P. Rhee, et al.

J Trauma Acute Care Surg. 2016;81(2):254-60

Assessment of operative risk in geriatric patients undergoing emergency general surgery (EGS) is challenging. Frailty is an established measure for risk assessment in surgical cases. The aim of our study was to validate a modified 15 variable emergency general surgery specific frailty index (EGSFI). Data obtained suggest that the 15-variable validated EGSFI is a simple and reliable bedside tool to determine the frailty status of patients undergoing emergency general surgery.
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Prediction of one-year mortality by five different frailty instruments: A comparative study in hospitalized geriatric patients

M. Ritt, L.C. Bollheimer, C.C. Sieber, et al.

Arch Gerontol Geriatr. 2016;66:66-72

307 patients ≥65years who were hospitalized in geriatric wards were included in this prospective analysis. A fifty-item frailty index (FI), a ten-domain+co-morbidity frailty index based on a standardized comprehensive geriatric assessment (FI-CGA), the nine category Clinical Frailty Scale (CFS-9), the CSHA rules-based frailty definition (CSHA-RBFD), and the frailty phenotype (FP) were assessed during the patients' hospital stays. Among those frailty instruments that were evaluated, the CFS-9 emerged as the most powerful for prediction of one-year mortality.
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Case finding for sarcopenia in geriatric inpatients: performance of bioimpedance analysis in comparison to dual X-ray absorptiometry

J. Reiss, B. Iglseder, M. Kreutzer, et al.

BMC Geriatr. 2016;16(1):52

The European Working Group on Sarcopenia in Older People (EWGSOP) suggests different methods for case finding for sarcopenia. However, data comparing the different methodological options are scarce for geriatric inpatients. Muscle mass measured by BIA was highly correlated to DXA (r > 0.9), but BIA systematically overestimated muscle mass. The raw agreement between the DXA- and BIA-based approaches for classifying participants as having normal or reduced muscle mass was at best 80 % depending on the BIA cut-offs used.
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Frailty Is Associated with an Increased Risk of Incident Type 2 Diabetes in the Elderly

N. Veronese, B. Stubbs, L. Fontana, et al.

J Am Med Dir Assoc. 2016;17(10):902-7

This longitudinal study (follow-up of 4.4 years) aimed to investigate whether frailty is associated with an increased risk of incident type 2 diabetes mellitus (T2DM) in a prospective cohort of community-dwelling older people. Among community-dwelling older people, frailty and prefrailty were significant and independent predictors of T2DM, which is a major and potentially preventable risk factor for multiple comorbidities.
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Frailty as a major factor in the increate risk of death and disability in older people with diabetes

M. Castro-Rodríguez, J.A. Carnicero, F. J. Garcia-Garcia, et al.

J Am Med Dir Assoc. 2016;17(10):949-55

The objective of this prospective cohort study on 1825 individuals (≥65years old) was to assess the role of frailty in predicting death and incident disability in older adults with type 2 diabetes mellitus. The results obtained suggest that frailty is an important risk factor for death and disability in older adults with diabetes, supporting the recent recommendations that frailty status should be routinely assessed in these patients.
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Prevalence of Frailty and Factors Associated with Frailty in Individuals Aged 90 and Older: The 90+ Study

D.R. Lee, C.H. Kawas, L. Gibbs, et al.

J Am Geriatr Soc. 2016;64(11):2257-2262

This study estimated the overall prevalence of frailty in people aged 90 and older to be 28.0%. The overall prevalence of frailty was 24% in those aged 90 to 94 and 39.5% in those aged 95 and older. The prevalence of frailty was significantly associated with age in women but not men and with living with relatives or caregiver or in a group setting.
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Prevalence and Incidence of Frailty in Community-Dwelling Older People: Beijing Longitudinal Study of Aging II

Z. Zheng, S. Guan, H. Ding, et al.

J Am Geriatr Soc. 2016;64(6):1281-6

The objective of this secondary analysis of a prospective cohort study was to estimate the prevalence and incidence of frailty and evaluate the effect of frailty on adverse outcomes in 10,039 Chinese elderly adults (≥55 years). A 12.3% prevalence and a 13% incidence of frailty was demonstrated in community-dwelling Chinese older adults.
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