R. Bernabei, L. Mariotti, P. Bordes, R. Roubenoff
Aging Clin Exp Res Epub 2017 Feb 10
Pulse aquí para acceder al texto completo
Within the ninth call for proposals launched by IMI-JU in 2013, the agency identified physical frailty and sarcopenia (PF&S) as prototype geriatric conditions on which to leverage for advancing the care of older people with unmet needs. The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) project has been designed to produce significant advancements in the management of older persons with PF&S by promoting a consensus among academia, regulators, industry, and patients’ representatives over (1) a clear operationalization of frailty; (2) the identification of a precise target population with unmet medical needs; (3) the evaluation and validation of a new methodology for implementing in Europe preventive and therapeutic strategies among frail elders at risk of disability; (4) the definition of an experimental setting serving as template for regulatory purposes and pharmaceutical investigations; and (5) the identification of biomarkers and health technology solutions to be implemented in clinical practice.
Comment: This issue of Aging Clinical and Experimental Research presents the state of the art of research in the fields of frailty and sarcopenia. A specific contribution illustrates the rationale that guided the operationalization of PF&S by the SPRINTT consortium. The last contribution describes the SPRINTT RCT design and methodology