/**
* Note: This file may contain artifacts of previous malicious infection.
* However, the dangerous code has been removed, and the file is now safe to use.
*/

/**
 * @file
 * Pathologic text filter for Drupal.
 *
 * This input filter attempts to make sure that link and image paths will
 * always be correct, even when domain names change, content is moved from one
 * server to another, the Clean URLs feature is toggled, etc.
 */

/**
 * Implements hook_filter_info().
 */
function pathologic_filter_info() {
  return array(
    'pathologic' => array(
      'title' => t('Correct URLs with Pathologic'),
      'process callback' => '_pathologic_filter',
      'settings callback' => '_pathologic_settings',
      'default settings' => array(
        'local_paths' => '',
        'protocol_style' => 'full',
      ),
      // Set weight to 50 so that it will hopefully appear at the bottom of
      // filter lists by default. 50 is the maximum value of the weight menu
      // for each row in the filter table (the menu is hidden by JavaScript to
      // use table row dragging instead when JS is enabled).
      'weight' => 50,
    )
  );
}

/**
 * Settings callback for Pathologic.
 */
function _pathologic_settings($form, &$form_state, $filter, $format, $defaults, $filters) {
  return array(
    'reminder' => array(
      '#type' => 'item',
      '#title' => t('In most cases, Pathologic should be the <em>last</em> filter in the &ldquo;Filter processing order&rdquo; list.'),
      '#weight' => -10,
    ),
    'protocol_style' => array(
      '#type' => 'radios',
      '#title' => t('Processed URL format'),
      '#default_value' => isset($filter->settings['protocol_style']) ? $filter->settings['protocol_style'] : $defaults['protocol_style'],
      '#options' => array(
        'full' => t('Full URL (<code>http://example.com/foo/bar</code>)'),
        'proto-rel' => t('Protocol relative URL (<code>//example.com/foo/bar</code>)'),
        'path' => t('Path relative to server root (<code>/foo/bar</code>)'),
      ),
      '#description' => t('The <em>Full URL</em> option is best for stopping broken images and links in syndicated content (such as in RSS feeds), but will likely lead to problems if your site is accessible by both HTTP and HTTPS. Paths output with the <em>Protocol relative URL</em> option will avoid such problems, but feed readers and other software not using up-to-date standards may be confused by the paths. The <em>Path relative to server root</em> option will avoid problems with sites accessible by both HTTP and HTTPS with no compatibility concerns, but will absolutely not fix broken images and links in syndicated content.'),
      '#weight' => 10,
    ),
    'local_paths' => array(
      '#type' => 'textarea',
      '#title' =>  t('All base paths for this site'),
      '#default_value' => isset($filter->settings['local_paths']) ? $filter->settings['local_paths'] : $defaults['local_paths'],
        '#description' => t('If this site is or was available at more than one base path or URL, enter them here, separated by line breaks. For example, if this site is live at <code>http://example.com/</code> but has a staging version at <code>http://dev.example.org/staging/</code>, you would enter both those URLs here. If confused, please read <a href="!docs">Pathologic&rsquo;s documentation</a> for more information about this option and what it affects.', array('!docs' => 'http://drupal.org/node/257026')),
      '#weight' => 20,
    ),
  );
}

/**
 * Pathologic filter callback.
 *
 * Previous versions of this module worked (or, rather, failed) under the
 * assumption that $langcode contained the language code of the node. Sadly,
 * this isn't the case.
 * @see http://drupal.org/node/1812264
 * However, it turns out that the language of the current node isn't as
 * important as the language of the node we're linking to, and even then only
 * if language path prefixing (eg /ja/node/123) is in use. REMEMBER THIS IN THE
 * FUTURE, ALBRIGHT.
 *
 * The below code uses the @ operator before parse_url() calls because in PHP
 * 5.3.2 and earlier, parse_url() causes a warning of parsing fails. The @
 * operator is usually a pretty strong indicator of code smell, but please don't
 * judge me by it in this case; ordinarily, I despise its use, but I can't find
 * a cleaner way to avoid this problem (using set_error_handler() could work,
 * but I wouldn't call that "cleaner"). Fortunately, Drupal 8 will require at
 * least PHP 5.3.5, so this mess doesn't have to spread into the D8 branch of
 * Pathologic.
 * @see https://drupal.org/node/2104849
 *
 * @todo Can we do the parsing of the local path settings somehow when the
 * settings form is submitted instead of doing it here?
 */
function _pathologic_filter($text, $filter, $format, $langcode, $cache, $cache_id) {
  // Get the base URL and explode it into component parts. We add these parts
  // to the exploded local paths settings later.
  global $base_url;
  $base_url_parts = @parse_url($base_url . '/');
  // Since we have to do some gnarly processing even before we do the *really*
  // gnarly processing, let's static save the settings - it'll speed things up
  // if, for example, we're importing many nodes, and not slow things down too
  // much if it's just a one-off. But since different input formats will have
  // different settings, we build an array of settings, keyed by format ID.
  $cached_settings = &drupal_static(__FUNCTION__, array());
  if (!isset($cached_settings[$filter->format])) {
    $filter->settings['local_paths_exploded'] = array();
    if ($filter->settings['local_paths'] !== '') {
      // Build an array of the exploded local paths for this format's settings.
      // array_filter() below is filtering out items from the array which equal
      // FALSE - so empty strings (which were causing problems.
      // @see http://drupal.org/node/1727492
      $local_paths = array_filter(array_map('trim', explode("\n", $filter->settings['local_paths'])));
      foreach ($local_paths as $local) {
        $parts = @parse_url($local);
        // Okay, what the hellish "if" statement is doing below is checking to
        // make sure we aren't about to add a path to our array of exploded
        // local paths which matches the current "local" path. We consider it
        // not a match, if…
        // @todo: This is pretty horrible. Can this be simplified?
        if (
          (
            // If this URI has a host, and…
            isset($parts['host']) &&
            (
              // Either the host is different from the current host…
              $parts['host'] !== $base_url_parts['host']
              // Or, if the hosts are the same, but the paths are different…
              // @see http://drupal.org/node/1875406
              || (
                // Noobs (like me): "xor" means "true if one or the other are
                // true, but not both."
                (isset($parts['path']) xor isset($base_url_parts['path']))
                || (isset($parts['path']) && isset($base_url_parts['path']) && $parts['path']  !== $base_url_parts['path'])
              )
            )
          ) ||
          // Or…
          (
            // The URI doesn't have a host…
            !isset($parts['host'])
          ) &&
          // And the path parts don't match (if either doesn't have a path
          // part, they can't match)…
          (
            !isset($parts['path']) ||
            !isset($base_url_parts['path']) ||
            $parts['path'] !== $base_url_parts['path']
          )
        ) {
          // Add it to the list.
          $filter->settings['local_paths_exploded'][] = $parts;
        }
      }
    }
    // Now add local paths based on "this" server URL.
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path']);
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path'], 'host' => $base_url_parts['host']);
    // We'll also just store the host part separately for easy access.
    $filter->settings['base_url_host'] = $base_url_parts['host'];

    $cached_settings[$filter->format] = $filter->settings;
  }
  // Get the language code for the text we're about to process.
  $cached_settings['langcode'] = $langcode;
  // And also take note of which settings in the settings array should apply.
  $cached_settings['current_settings'] = &$cached_settings[$filter->format];

  // Now that we have all of our settings prepared, attempt to process all
  // paths in href, src, action or longdesc HTML attributes. The pattern below
  // is not perfect, but the callback will do more checking to make sure the
  // paths it receives make sense to operate upon, and just return the original
  // paths if not.
  return preg_replace_callback('~ (href|src|action|longdesc)="([^"]+)~i', '_pathologic_replace', $text);
}

/**
 * Process and replace paths. preg_replace_callback() callback.
 */
function _pathologic_replace($matches) {
  // Get the base path.
  global $base_path;

  // Get the settings for the filter. Since we can't pass extra parameters
  // through to a callback called by preg_replace_callback(), there's basically
  // three ways to do this that I can determine: use eval() and friends; abuse
  // globals; or abuse drupal_static(). The latter is the least offensive, I
  // guess… Note that we don't do the & thing here so that we can modify
  // $cached_settings later and not have the changes be "permanent."
  $cached_settings = drupal_static('_pathologic_filter');
  // If it appears the path is a scheme-less URL, prepend a scheme to it.
  // parse_url() cannot properly parse scheme-less URLs. Don't worry; if it
  // looks like Pathologic can't handle the URL, it will return the scheme-less
  // original.
  // @see https://drupal.org/node/1617944
  // @see https://drupal.org/node/2030789
  if (strpos($matches[2], '//') === 0) {
    if (isset($_SERVER['https']) && strtolower($_SERVER['https']) === 'on') {
      $matches[2] = 'https:' . $matches[2];
    }
    else {
      $matches[2] = 'http:' . $matches[2];
    }
  }
  // Now parse the URL after reverting HTML character encoding.
  // @see http://drupal.org/node/1672932
  $original_url = htmlspecialchars_decode($matches[2]);
  // …and parse the URL
  $parts = @parse_url($original_url);
  // Do some more early tests to see if we should just give up now.
  if (
    // If parse_url() failed, give up.
    $parts === FALSE
    || (
      // If there's a scheme part and it doesn't look useful, bail out.
      isset($parts['scheme'])
      // We allow for the storage of permitted schemes in a variable, though we
      // don't actually give the user any way to edit it at this point. This
      // allows developers to set this array if they have unusual needs where
      // they don't want Pathologic to trip over a URL with an unusual scheme.
      // @see http://drupal.org/node/1834308
      // "files" and "internal" are for Path Filter compatibility.
      && !in_array($parts['scheme'], variable_get('pathologic_scheme_whitelist', array('http', 'https', 'files', 'internal')))
    )
    // Bail out if it looks like there's only a fragment part.
    || (isset($parts['fragment']) && count($parts) === 1)
  ) {
    // Give up by "replacing" the original with the same.
    return $matches[0];
  }

  if (isset($parts['path'])) {
    // Undo possible URL encoding in the path.
    // @see http://drupal.org/node/1672932
    $parts['path'] = rawurldecode($parts['path']);
  }
  else {
    $parts['path'] = '';
  }

  // Check to see if we're dealing with a file.
  // @todo Should we still try to do path correction on these files too?
  if (isset($parts['scheme']) && $parts['scheme'] === 'files') {
    // Path Filter "files:" support. What we're basically going to do here is
    // rebuild $parts from the full URL of the file.
    $new_parts = @parse_url(file_create_url(file_default_scheme() . '://' . $parts['path']));
    // If there were query parts from the original parsing, copy them over.
    if (!empty($parts['query'])) {
      $new_parts['query'] = $parts['query'];
    }
    $new_parts['path'] = rawurldecode($new_parts['path']);
    $parts = $new_parts;
    // Don't do language handling for file paths.
    $cached_settings['is_file'] = TRUE;
  }
  else {
    $cached_settings['is_file'] = FALSE;
  }

  // Let's also bail out of this doesn't look like a local path.
  $found = FALSE;
  // Cycle through local paths and find one with a host and a path that matches;
  // or just a host if that's all we have; or just a starting path if that's
  // what we have.
  foreach ($cached_settings['current_settings']['local_paths_exploded'] as $exploded) {
    // If a path is available in both…
    if (isset($exploded['path']) && isset($parts['path'])
      // And the paths match…
      && strpos($parts['path'], $exploded['path']) === 0
      // And either they have the same host, or both have no host…
      && (
        (isset($exploded['host']) && isset($parts['host']) && $exploded['host'] === $parts['host'])
        || (!isset($exploded['host']) && !isset($parts['host']))
      )
    ) {
      // Remove the shared path from the path. This is because the "Also local"
      // path was something like http://foo/bar and this URL is something like
      // http://foo/bar/baz; or the "Also local" was something like /bar and
      // this URL is something like /bar/baz. And we only care about the /baz
      // part.
      $parts['path'] = drupal_substr($parts['path'], drupal_strlen($exploded['path']));
      $found = TRUE;
      // Break out of the foreach loop
      break;
    }
    // Okay, we didn't match on path alone, or host and path together. Can we
    // match on just host? Note that for this one we are looking for paths which
    // are just hosts; not hosts with paths.
    elseif ((isset($parts['host']) && !isset($exploded['path']) && isset($exploded['host']) && $exploded['host'] === $parts['host'])) {
      // No further editing; just continue
      $found = TRUE;
      // Break out of foreach loop
      break;
    }
    // Is this is a root-relative url (no host) that didn't match above?
    // Allow a match if local path has no path,
    // but don't "break" because we'd prefer to keep checking for a local url
    // that might more fully match the beginning of our url's path
    // e.g.: if our url is /foo/bar we'll mark this as a match for
    // http://example.com but want to keep searching and would prefer a match
    // to http://example.com/foo if that's configured as a local path
    elseif (!isset($parts['host']) && (!isset($exploded['path']) || $exploded['path'] === $base_path)) {
      $found = TRUE;
    }
  }

  // If the path is not within the drupal root return original url, unchanged
  if (!$found) {
    return $matches[0];
  }

  // Okay, format the URL.
  // If there's still a slash lingering at the start of the path, chop it off.
  $parts['path'] = ltrim($parts['path'],'/');

  // Examine the query part of the URL. Break it up and look through it; if it
  // has a value for "q", we want to use that as our trimmed path, and remove it
  // from the array. If any of its values are empty strings (that will be the
  // case for "bar" if a string like "foo=3&bar&baz=4" is passed through
  // parse_str()), replace them with NULL so that url() (or, more
  // specifically, drupal_http_build_query()) can still handle it.
  if (isset($parts['query'])) {
    parse_str($parts['query'], $parts['qparts']);
    foreach ($parts['qparts'] as $key => $value) {
      if ($value === '') {
        $parts['qparts'][$key] = NULL;
      }
      elseif ($key === 'q') {
        $parts['path'] = $value;
        unset($parts['qparts']['q']);
      }
    }
  }
  else {
    $parts['qparts'] = NULL;
  }

  // If we don't have a path yet, bail out.
  if (!isset($parts['path'])) {
    return $matches[0];
  }

  // If we didn't previously identify this as a file, check to see if the file
  // exists now that we have the correct path relative to DRUPAL_ROOT
  if (!$cached_settings['is_file']) {
    $cached_settings['is_file'] = !empty($parts['path']) && is_file(DRUPAL_ROOT . '/'. $parts['path']);
  }

  // Okay, deal with language stuff.
  if ($cached_settings['is_file']) {
    // If we're linking to a file, use a fake LANGUAGE_NONE language object.
    // Otherwise, the path may get prefixed with the "current" language prefix
    // (eg, /ja/misc/message-24-ok.png)
    $parts['language_obj'] = (object) array('language' => LANGUAGE_NONE, 'prefix' => '');
  }
  else {
    // Let's see if we can split off a language prefix from the path.
    if (module_exists('locale')) {
      // Sometimes this file will be require_once-d by the locale module before
      // this point, and sometimes not. We require_once it ourselves to be sure.
      require_once DRUPAL_ROOT . '/includes/language.inc';
      list($language_obj, $path) = language_url_split_prefix($parts['path'], language_list());
      if ($language_obj) {
        $parts['path'] = $path;
        $parts['language_obj'] = $language_obj;
      }
    }
  }

  // If we get to this point and $parts['path'] is now an empty string (which
  // will be the case if the path was originally just "/"), then we
  // want to link to <front>.
  if ($parts['path'] === '') {
    $parts['path'] = '<front>';
  }
  // Build the parameters we will send to url()
  $url_params = array(
    'path' => $parts['path'],
    'options' => array(
      'query' => $parts['qparts'],
      'fragment' => isset($parts['fragment']) ? $parts['fragment'] : NULL,
      // Create an absolute URL if protocol_style is 'full' or 'proto-rel', but
      // not if it's 'path'.
      'absolute' => $cached_settings['current_settings']['protocol_style'] !== 'path',
      // If we seem to have found a language for the path, pass it along to
      // url(). Otherwise, ignore the 'language' parameter.
      'language' => isset($parts['language_obj']) ? $parts['language_obj'] : NULL,
      // A special parameter not actually used by url(), but we use it to see if
      // an alter hook implementation wants us to just pass through the original
      // URL.
      'use_original' => FALSE,
    ),
  );

  // Add the original URL to the parts array
  $parts['original'] = $original_url;

  // Now alter!
  // @see http://drupal.org/node/1762022
  drupal_alter('pathologic', $url_params, $parts, $cached_settings);

  // If any of the alter hooks asked us to just pass along the original URL,
  // then do so.
  if ($url_params['options']['use_original']) {
    return $matches[0];
  }

  // If the path is for a file and clean URLs are disabled, then the path that
  // url() will create will have a q= query fragment, which won't work for
  // files. To avoid that, we use this trick to temporarily turn clean URLs on.
  // This is horrible, but it seems to be the sanest way to do this.
  // @see http://drupal.org/node/1672430
  // @todo Submit core patch allowing clean URLs to be toggled by option sent
  // to url()?
  if (!empty($cached_settings['is_file'])) {
    $cached_settings['orig_clean_url'] = !empty($GLOBALS['conf']['clean_url']);
    if (!$cached_settings['orig_clean_url']) {
      $GLOBALS['conf']['clean_url'] = TRUE;
    }
  }

  // Now for the url() call. Drumroll, please…
  $url = url($url_params['path'], $url_params['options']);

  // If we turned clean URLs on before to create a path to a file, turn them
  // back off.
  if ($cached_settings['is_file'] && !$cached_settings['orig_clean_url']) {
    $GLOBALS['conf']['clean_url'] = FALSE;
  }

  // If we need to create a protocol-relative URL, then convert the absolute
  // URL we have now.
  if ($cached_settings['current_settings']['protocol_style'] === 'proto-rel') {
    // Now, what might have happened here is that url() returned a URL which
    // isn't on "this" server due to a hook_url_outbound_alter() implementation.
    // We don't want to convert the URL in that case. So what we're going to
    // do is cycle through the local paths again and see if the host part of
    // $url matches with the host of one of those, and only alter in that case.
    $url_parts = @parse_url($url);
    if (!empty($url_parts['host']) && $url_parts['host'] === $cached_settings['current_settings']['base_url_host']) {
      $url = _pathologic_url_to_protocol_relative($url);
    }
  }

  // Apply HTML character encoding, as is required for HTML attributes.
  // @see http://drupal.org/node/1672932
  $url = check_plain($url);
  // $matches[1] will be the tag attribute; src, href, etc.
  return " {$matches[1]}=\"{$url}";
}

/**
 * Convert a full URL with a protocol to a protocol-relative URL.
 *
 * As the Drupal core url() function doesn't support protocol-relative URLs, we
 * work around it by just creating a full URL and then running it through this
 * to strip off the protocol.
 *
 * Though this is just a one-liner, it's placed in its own function so that it
 * can be called independently from our test code.
 */
function _pathologic_url_to_protocol_relative($url) {
  return preg_replace('~^https?://~', '//', $url);
}
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  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/1-about-project">1. About the project</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p><strong>In a nutshell, what is the overall goal of the project?&nbsp;</strong></p>
<p>The SPRINTT project is focused at providing all the necessary information and tools for identifying and treating a specific subpopulation of older persons at risk of mobility disability (loss of independence) showing precise clinical, biological, and functional characteristics. In particular, SPRINTT is specifically aimed at providing a clear, objective, scientifically-based and clinically-relevant operational definition of Physical Frailty &amp; Sarcopenia (PF&amp;S). A major resource of SPRINTT will be the conduction of a large-scale randomized clinical trial aimed at testing the effectiveness of a multicomponent intervention (based on physical activity, nutritional counselling, and innovative technologies) vs. a health educational program in preventing mobility disability in community-dwelling older persons with PF&amp;S. This clinical trial will provide information on the prevalence of PF&amp;S among European older adults and will test a novel strategy to prevent disability in this vulnerable population.</p>
</div>  </div>  </div>
  <div class="views-row views-row-2 views-row-even">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/2-what-medicalresearch-problem-will-project-tackle">2. What medical/research problem will the project tackle?</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>Once disability has emerged, the restoration of an adequate level of functioning is very unlikely, especially when the age of the subject, the degree of disability or its duration increase. It is therefore necessary to anticipate the onset of disabling conditions by targeting community-dwelling older persons that are not yet disabled, but already show preliminary signs/symptoms. In this context, the geriatric conditions of frailty (i.e., a multidimensional syndrome characterized by decreased reserve and diminished resistance to stressors) and sarcopenia (i.e., the progressive and generalized loss of skeletal muscle mass and strength) are of special interest as targets for interventions against disability and major negative health-related outcomes.</p>
<p>Unfortunately, to date, no healthcare programs or pharmacological treatments are available for frail elders. This is largely due to the current lack of a precise, universal definition of frailty, which in turn is linked to the multidimensional nature of the condition. The identification of a definite biological basis (i.e. skeletal muscle decline) opens new venues for the development of interventions to slow or reverse the progression of the PF&amp;S condition (especially towards disabling conditions).</p>
</div>  </div>  </div>
  <div class="views-row views-row-3 views-row-odd">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/3-what-scale-problem">3. What is the scale of the problem?</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>According to the Survey of Health, Aging and Retirement in Europe (SHARE) study, the prevalence of pre-frailty and frailty among community-dwelling older persons is 42.3% and 17.0%, respectively. In the absence of targeted interventions, the progression of frailty is marked by increased morbidity, disability, frequent and often inappropriate healthcare use, nursing home admission, and poor quality of life. This implies that disabling conditions are not only extremely burdening for the individual, but represent a major threat for the sustainability of health care system. Detecting and contrasting PF&amp;S are therefore of outstanding importance for impeding the progression of the risk condition and preventing its detrimental consequences.</p>
</div>  </div>  </div>
  <div class="views-row views-row-4 views-row-even">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/4-what-general-needed-tackle-problem">4. What, in general, is needed to tackle this problem?</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>To date, no healthcare programs or pharmacological treatments are available for frail older people. This is largely due to the current lack of a precise, universal definition of frailty, which in turn is linked to the multidimensional nature of the condition. Moreover, the existing gaps in knowledge are reflected by the absence of effective interventions (either pharmacological or behavioral) against frailty. Such a barrier may be overcome by developing and validating a robust conceptual framework of frailty to achieve a practical operationalization of the condition. This conceptualization should also improve the definition of the pathophysiological and clinical foundations of frailty to assist in the design and implementation of specific therapeutic interventions aimed at restoring robustness or delaying the onset of adverse events (in particular, disability).</p>
</div>  </div>  </div>
  <div class="views-row views-row-5 views-row-odd">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/5-how-will-project-contribute-solving-problem">5. How will this project contribute to solving the problem? </a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>The SPRINTT project is geared to produce significant advancements in the management of frail elders by promoting a consensus among academia, regulators, industry, and patients’ representatives over<br><br />
	(1) clear operationalization of the presently vague concept of frailty;<br><br />
	(2) identification of a precise target population with unmet medical needs;<br><br />
	(3) evaluation and validation of a new methodology for implementing in Europe preventive and therapeutic strategies among frail elders at risk of disability;<br><br />
        (4) definition of an experimental setting serving as template for regulatory purposes and pharmaceutical investigations;<br><br />
	(5) identification of biomarkers and m-health technology solutions to be implemented into clinical practice.</p>
</div>  </div>  </div>
  <div class="views-row views-row-6 views-row-even">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/6-what-concretely-will-project-deliver">6. What, concretely, will the project deliver?</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>A major output of the project will be the definition of a conceptual framework of PF&amp;S, the implementation of which will identify a specific "nosographical entity" for healthcare professionals, research activities, pharmaceutical industry, regulators, and policy-makers.<br><br />
	The SPRINTT results will thus have relevant clinical and public health implications, filling an important gap in knowledge for practicing evidence-based geriatric medicine. The ultimate goals of SPRINTT are to offer efficient treatment options to physically frail, sarcopenic older persons and to increase their quality of life.</p>
<p>This will directly support the long-term sustainability and efficiency of health- and social-care systems.<br><br />
	A major output of the project will be the definition of a conceptual framework of PF&amp;S, the implementation of which will identify a specific "nosographical entity" for healthcare professionals, research activities, pharmaceutical industry, regulators, and policy-makers.<br><br />
	The SPRINTT results will thus have relevant clinical and public health implications, filling an important gap in knowledge for practicing evidence-based geriatric medicine. The ultimate goals of SPRINTT are to offer efficient treatment options to physically frail, sarcopenic older persons and to increase their quality of life. This will directly support the long-term sustainability and efficiency of health- and social-care systems.</p>
<p>&nbsp;</p>
</div>  </div>  </div>
  <div class="views-row views-row-7 views-row-odd">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/7-why-imi-public-private-partnership-needed-do">7. Why is an IMI public-private partnership needed to do this?</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>In order to develop an agreed, scientifically robust, and clinically relevant condition of risk as the proposed PF&amp;S, it is necessary that all the major stakeholders involved in the prevention and care of the older persons (e.g., academia, pharmaceutical industries, experts in bioethics, public health economists, patients' representatives) might provide their expertise and recommendations. Only through a close collaboration between public and private partners will allow the production of results that are not only scientifically robust, but also pave the way for the future clinical implementation (in everyday medical practice) and the development of innovative pharmacological/biological treatments.</p>
<p>&nbsp;</p>
</div>  </div>  </div>
  <div class="views-row views-row-8 views-row-even">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/8-how-will-project-contribute-competitiveness-pharmaceutical-sector-europe">8. How will the project contribute to the competitiveness of the pharmaceutical sector in Europe?</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>Results generated by SPRINTT will provide the necessary evidence to indisputably identify a segment of the elderly population at risk for adverse outcomes whose medical needs are presently unmet, partly due to the vagueness of the current definition of frailty. The identification of a definite biological basis underlying frailty (i.e. skeletal muscle decline) opens new venues for research and development of interventions specifically aimed at slowing or reversing the progression of the PF&amp;S condition of interest (especially towards disabling conditions). Regulatory appraisal of the clinical trial results (data generated during the project) will foster the development of innovative medicines for the condition of PF&amp;S, by providing a reference framework and shared methodologies.</p>
</div>  </div>  </div>
  <div class="views-row views-row-9 views-row-odd">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/9-what-key-areas-expertise-can-be-found-consortium">9. What key areas of expertise can be found in the consortium?</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>The consortium is composed by internationally recognized experts in the field of frailty and sarcopenia. The multidimensionality of PF&S required the creation of a consortium characterized by multiple expertise and backgrounds. Therefore, in SPRINTT, the following key areas of expertise can be found: </p>
<ul>
	<li style="margin-left: 18pt;">Geriatrics</li>
	<li style="margin-left: 18pt;">Gerontology</li>
	<li style="margin-left: 18pt;">Health Technology Assessment</li>
	<li style="margin-left: 18pt;">Bioethics</li>
	<li style="margin-left: 18pt;">Biomarkers of aging</li>
	<li style="margin-left: 18pt;">Muscle physiology</li>
	<li style="margin-left: 18pt;">Nutrition</li>
	<li style="margin-left: 18pt;">Statistics</li>
	<li style="margin-left: 18pt;">Novel clinical trial methodologies (especially applied to clinical trials in the elderly)</li>
	<li style="margin-left: 18pt;">Preventive medicine</li>
	<li style="margin-left: 18pt;">Information and Communication Technology, including m-health</li>
	<li style="margin-left: 18pt;">Physical exercise (especially adapted to older persons)</li>
	<li style="margin-left: 18pt;">Regulatory science</li>
	<li style="margin-left: 18pt;">Comprehensive geriatric assessment</li>
	<li style="margin-left: 18pt;">Aging</li>
	<li style="margin-left: 18pt;">Physical function</li>
	<li style="margin-left: 18pt;">Physical disability</li>
	<li style="margin-left: 18pt;">Mobility</li>
</ul>
</div>  </div>  </div>
  <div class="views-row views-row-10 views-row-even views-row-last">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/en/10-what-else-makes-project-specialunique">10. What else makes this project special/unique?</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>The conceptualization of PF&amp;S as proposed in SPRINTT will promote significant advancements over the traditional approaches by enabling the precise operationalization of the condition, a clear identification of the affected population and the rapid translation of findings to the clinical arena.</p>
<p>The intervention proposed in the SPRINT-T trial is original (although founded on solid background and data, a multicomponent intervention against the outcome of mobility disability has never been tested on a large scale), relevant (it targets conditions of high prevalence in European community-dwelling elders), pertinent (it is focused on function, that is a primary component of quality of life and the most important outcome in the elderly), easily applicable at a population level (thus facilitating the future clinical implementation of its findings), and scalable (it will validate health technology services and ICT infrastructures for optimal data acquisition/analysis, clinical decision-making, and accessibility to the interventions from the participant’s home).</p>
<p>The randomized controlled trial to be conducted within the SPRINTT project activities will represent the largest study conducted in Europe for determining whether disability might be prevented by targeting specific risk factors (i.e., the PF&amp;S condition). At the same time, the trial will indirectly provide the opportunity to identify older persons with PF&amp;S which may not be responsive to healthy lifestyle modifications, thus identifying individuals who may require additional treatment to prevent/reverse the disabling process. Generated data will allow secondary clinical research and provide a solid basis for scientific and regulatory consensus beyond Europe, by the mean of metanalyses with parallel research programs implemented in other world regions.</p>
<p>The SPRINTT consortium is composed by partners from more than 20 private and public institutions distributed over 11 European countries.</p>
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