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M.J. Mohler, C.S. Wendel , R.E. Taylor-Piliae, et al.Gerontology. 2016;62(6):654-664 This study aimed to evaluate wearable sensor-based measures of gait, balance, and physical activity that are predictive of future falls in community-dwelling older adults. Results obtained suggests that independent predictors of falls are dependent on frailty status. Among sensor-derived parameters, balance deficit, longer typical walking episodes, and shorter typical standing episodes were the most sensitive predictors of prospective falls in the combined pre-frail and frail sample. Gait deficit was not a sensitive fall predictor in the context of frailty status. |
T. Morat, K.J. Gilmore and C.L. RiceExp Gerontol. 2016;81:28-36 This study applied the screening tool developed by the European Working Group on Sarcopenia in Older People (EWGSOP) on seniors aged over 65years and concurrently tested various laboratory-based indices of neuromuscular function. Based on gait speed, handgrip strength and muscle mass all subjects were categorized into one of the three conceptual sarcopenia stages (pre-sarcopenia, sarcopenia, severe sarcopenia). The laboratory tests found neuromuscular differences among the 3 groups which generally supported the classification scheme and helped to illustrate some key factors that could explain differences in functional capacities. |
J.I. Yoo, Y.C. Ha, Y.K. Lee, et al.J Bone Metab. 2016;23(2):101-9 Despite increasing concern regarding health problems as a result of environmental pollutants, no association of toxic heavy metals with sarcopenia has been demonstrated in the general population. In this article the association of heavy metals, including lead, mercury and cadmium, with sarcopenia in the Korean population was investigated. This study demonstrates that high levels of blood lead, mercury and cadmium increase the prevalence of sarcopenia in both genders of elderly populations. |
H. Sandoval-Insausti, R.F. Pérez-Tasigchana, E. López-García, et al.J Gerontol A Biol Sci Med Sci. 2016;71(10):1329-34 This study examined the association of protein and other macronutrient intake with the risk of frailty in older adults. Authors concluded that the intake of total protein, animal protein, and MUFAs was inversely associated with incident frailty. Promoting the intake of these nutrients might reduce frailty. |
L.P. Breitling, K.U. Saum, L. Perna, et al.Clinical Epigenetics. 2016;8:21 The epigenetic clock, in particular epigenetic pre-aging quantified by the so-called DNA methylation age acceleration, has recently suggested to closely correlate with a variety of disease phenotypes. There remains a dearth of data, however, on its association with telomere length and frailty, which can be considered major correlates of age on the genomic and clinical level, respectively. The results of the present study suggest that epigenetic age acceleration is correlated with clinically relevant aging-related phenotypes through pathways unrelated to cellular senescence as assessed by telomere length. |
M.S. Fragala, D.E. Alley, M.D. Shardell, et al.J Am Geriatr Soc.2016;64:144–150 This study aimed at comparing the relative predictive power of handgrip and leg extension strength in predicting slow walking. Results suggest that handgrip strength may be an adequate measure to predict physical function whereas leg extension strength is only a slightly better predictor of slow gait speed. |