For Healthcare Providers

The “Sarcopenia and Physical fRailty IN older people: multicomponenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods

F. Landi, M. Cesari, R. Calvani, et al.

Aging Clin Exp Res Epub 2017 Feb 10

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SPRINTT is a phase III, multicenter RCT aimed at comparing the efficacy of a MCI, based on long-term structured physical activity, nutritional counseling/dietary intervention, and an information and communication technology intervention, versus a healthy aging lifestyle education program designed to prevent mobility disability in 1500 older persons with physical frailty and sarcopenia who will be followed for up to 36 months.

 

Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial

M. Cesari, F. Landi, R. Calvani, et al.

Aging Clin Exp Res Epub 2017 Feb 10

CLICK HERE TO READ THE FULL TEXT

In the present article, the rationale that guided the operationalization of the theoretical concept of physical frailty and sarcopenia (PF&S), the condition of interest for the “Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies” (SPRINTT) trial, is presented.

The Predictive Value of the EWGSOP Definition of Sarcopenia: Results From the InCHIANTI Study

L. Bianchi , L. Ferrucci, A. Cherubini, et al.

J Gerontol A Biol Sci Med Sci. 2016;71(2):259-64

Aim of the study was to explore the predictive value of the European Working Group on Sarcopenia in Older People (EWGSOP) diagnostic algorithm in terms of disability, hospitalization, and mortality and analyze the specific role of grip strength and walking speed as diagnostic criteria for sarcopenia.

Results obtained suggest the EWGSOP's phenotype as a good predictor of incident disability, hospitalization and death.

 

Frailty as a Predictor of Acute Kidney Injury in Hospitalized Elderly Patients: A Single Center, Retrospective Cohort Study

S.H. Baek, S.W. Lee, S.W. Kim, et al.

PLoS One. 2016;11(6):e0156444

This study aimed at determining the effect of frailty as a predictor of acute kidney injury (AKI). 533 hospitalized elderly patients (aged ≥ 65 years) were retrospectively enrolled.

Data obtained suggest that frailty may independently predict the development of AKI and adverse outcomes in geriatric inpatients.

Prevalence and Incidence of Frailty in Community-Dwelling Older People: Beijing Longitudinal Study of Aging II

Z. Zheng, S. Guan, H. Ding, et al.

J Am Geriatr Soc. 2016;64(6):1281-6

The objective of this secondary analysis of a prospective cohort study was to estimate the prevalence and incidence of frailty and evaluate the effect of frailty on adverse outcomes in 10,039 Chinese elderly adults (≥55 years). A 12.3% prevalence and a 13% incidence of frailty was demonstrated in community-dwelling Chinese older adults.

Frailty as a predictor of hospitalisation among community-dwelling older people: a systematic review and meta-analysis

G. Kojima

J Epidemiol Community Health. 2016;70(7):722-9

This systematic review and meta-analysis demonstrated that physical frailty is a significant predictor of hospitalization among community-dwelling older people.

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