Für Forschende
N. Veronese, B. Stubbs, L. Fontana et al.J Am Med Dir Assoc. 2016 Jun 7. pii: S1525-8610(16)30115-3. doi: 10.1016/j.jamda.2016.04.021. [Epub ahead of print] This longitudinal study (follow-up of 4.4 years) aimed to investigate whether frailty is associated with an increased risk of incident type 2 diabetes mellitus (T2DM) in a prospective cohort of community-dwelling older people. Among community-dwelling older people, frailty and prefrailty were significant and independent predictors of T2DM, which is a major and potentially preventable risk factor for multiple comorbidities. |
J. Reiss, B. Iglseder, M. Kreutzer et al.BMC Geriatr. 2016;16(1):52 The European Working Group on Sarcopenia in Older People (EWGSOP) suggests different methods for case finding for sarcopenia. However, data comparing the different methodological options are scarce for geriatric inpatients. Muscle mass measured by BIA was highly correlated to DXA (r > 0.9), but BIA systematically overestimated muscle mass. The raw agreement between the DXA- and BIA-based approaches for classifying participants as having normal or reduced muscle mass was at best 80 % depending on the BIA cut-offs used. |
G. KojimaBone. 2016;90:116-122. This systematic review and meta-analysis showed evidence that pre-frailty and frailty are significant predictors of fractures among community-dwelling older people. |
B. Can, O. Kara, M.C. Kizilarslanoglu et al.Aging Clin Exp Res. 2016 Aug 29. [Epub ahead of print] The aim of the study was to evaluate the relationship between sarcopenia and biomarkers that may be involved in its pathogenesis and hence allow early detection. |
A.M. Holwerda, I.W. Kouw, J. Trommelen et al.J Nutr. 2016 Jun 8. pii: jn230086. [Epub ahead of print] The present study assessed whether physical activity performed in the evening can augment the overnight muscle protein synthetic response to presleep protein ingestion in older men. |
J. Yoshino , G.I. Smith, S.C. Kelly et al.Physiol Rep. 2016;4(11). pii: e12785. In this study, we used muscle biopsy samples collected during a recently completed randomized controlled trial that found that n-3 PUFA therapy increased muscle mass and function in older adults to provide a comprehensive assessment of the effect of n-3 PUFA therapy on the skeletal muscle gene expression profile in these people. Data obtained suggest that n-3 PUFA therapy results in small but coordinated changes in the muscle transcriptome that may help explain the n-3 PUFA-induced improvements in muscle mass and function. |