/**
* Note: This file may contain artifacts of previous malicious infection.
* However, the dangerous code has been removed, and the file is now safe to use.
*/

/**
 * @file
 * Pathologic text filter for Drupal.
 *
 * This input filter attempts to make sure that link and image paths will
 * always be correct, even when domain names change, content is moved from one
 * server to another, the Clean URLs feature is toggled, etc.
 */

/**
 * Implements hook_filter_info().
 */
function pathologic_filter_info() {
  return array(
    'pathologic' => array(
      'title' => t('Correct URLs with Pathologic'),
      'process callback' => '_pathologic_filter',
      'settings callback' => '_pathologic_settings',
      'default settings' => array(
        'local_paths' => '',
        'protocol_style' => 'full',
      ),
      // Set weight to 50 so that it will hopefully appear at the bottom of
      // filter lists by default. 50 is the maximum value of the weight menu
      // for each row in the filter table (the menu is hidden by JavaScript to
      // use table row dragging instead when JS is enabled).
      'weight' => 50,
    )
  );
}

/**
 * Settings callback for Pathologic.
 */
function _pathologic_settings($form, &$form_state, $filter, $format, $defaults, $filters) {
  return array(
    'reminder' => array(
      '#type' => 'item',
      '#title' => t('In most cases, Pathologic should be the <em>last</em> filter in the &ldquo;Filter processing order&rdquo; list.'),
      '#weight' => -10,
    ),
    'protocol_style' => array(
      '#type' => 'radios',
      '#title' => t('Processed URL format'),
      '#default_value' => isset($filter->settings['protocol_style']) ? $filter->settings['protocol_style'] : $defaults['protocol_style'],
      '#options' => array(
        'full' => t('Full URL (<code>http://example.com/foo/bar</code>)'),
        'proto-rel' => t('Protocol relative URL (<code>//example.com/foo/bar</code>)'),
        'path' => t('Path relative to server root (<code>/foo/bar</code>)'),
      ),
      '#description' => t('The <em>Full URL</em> option is best for stopping broken images and links in syndicated content (such as in RSS feeds), but will likely lead to problems if your site is accessible by both HTTP and HTTPS. Paths output with the <em>Protocol relative URL</em> option will avoid such problems, but feed readers and other software not using up-to-date standards may be confused by the paths. The <em>Path relative to server root</em> option will avoid problems with sites accessible by both HTTP and HTTPS with no compatibility concerns, but will absolutely not fix broken images and links in syndicated content.'),
      '#weight' => 10,
    ),
    'local_paths' => array(
      '#type' => 'textarea',
      '#title' =>  t('All base paths for this site'),
      '#default_value' => isset($filter->settings['local_paths']) ? $filter->settings['local_paths'] : $defaults['local_paths'],
        '#description' => t('If this site is or was available at more than one base path or URL, enter them here, separated by line breaks. For example, if this site is live at <code>http://example.com/</code> but has a staging version at <code>http://dev.example.org/staging/</code>, you would enter both those URLs here. If confused, please read <a href="!docs">Pathologic&rsquo;s documentation</a> for more information about this option and what it affects.', array('!docs' => 'http://drupal.org/node/257026')),
      '#weight' => 20,
    ),
  );
}

/**
 * Pathologic filter callback.
 *
 * Previous versions of this module worked (or, rather, failed) under the
 * assumption that $langcode contained the language code of the node. Sadly,
 * this isn't the case.
 * @see http://drupal.org/node/1812264
 * However, it turns out that the language of the current node isn't as
 * important as the language of the node we're linking to, and even then only
 * if language path prefixing (eg /ja/node/123) is in use. REMEMBER THIS IN THE
 * FUTURE, ALBRIGHT.
 *
 * The below code uses the @ operator before parse_url() calls because in PHP
 * 5.3.2 and earlier, parse_url() causes a warning of parsing fails. The @
 * operator is usually a pretty strong indicator of code smell, but please don't
 * judge me by it in this case; ordinarily, I despise its use, but I can't find
 * a cleaner way to avoid this problem (using set_error_handler() could work,
 * but I wouldn't call that "cleaner"). Fortunately, Drupal 8 will require at
 * least PHP 5.3.5, so this mess doesn't have to spread into the D8 branch of
 * Pathologic.
 * @see https://drupal.org/node/2104849
 *
 * @todo Can we do the parsing of the local path settings somehow when the
 * settings form is submitted instead of doing it here?
 */
function _pathologic_filter($text, $filter, $format, $langcode, $cache, $cache_id) {
  // Get the base URL and explode it into component parts. We add these parts
  // to the exploded local paths settings later.
  global $base_url;
  $base_url_parts = @parse_url($base_url . '/');
  // Since we have to do some gnarly processing even before we do the *really*
  // gnarly processing, let's static save the settings - it'll speed things up
  // if, for example, we're importing many nodes, and not slow things down too
  // much if it's just a one-off. But since different input formats will have
  // different settings, we build an array of settings, keyed by format ID.
  $cached_settings = &drupal_static(__FUNCTION__, array());
  if (!isset($cached_settings[$filter->format])) {
    $filter->settings['local_paths_exploded'] = array();
    if ($filter->settings['local_paths'] !== '') {
      // Build an array of the exploded local paths for this format's settings.
      // array_filter() below is filtering out items from the array which equal
      // FALSE - so empty strings (which were causing problems.
      // @see http://drupal.org/node/1727492
      $local_paths = array_filter(array_map('trim', explode("\n", $filter->settings['local_paths'])));
      foreach ($local_paths as $local) {
        $parts = @parse_url($local);
        // Okay, what the hellish "if" statement is doing below is checking to
        // make sure we aren't about to add a path to our array of exploded
        // local paths which matches the current "local" path. We consider it
        // not a match, if…
        // @todo: This is pretty horrible. Can this be simplified?
        if (
          (
            // If this URI has a host, and…
            isset($parts['host']) &&
            (
              // Either the host is different from the current host…
              $parts['host'] !== $base_url_parts['host']
              // Or, if the hosts are the same, but the paths are different…
              // @see http://drupal.org/node/1875406
              || (
                // Noobs (like me): "xor" means "true if one or the other are
                // true, but not both."
                (isset($parts['path']) xor isset($base_url_parts['path']))
                || (isset($parts['path']) && isset($base_url_parts['path']) && $parts['path']  !== $base_url_parts['path'])
              )
            )
          ) ||
          // Or…
          (
            // The URI doesn't have a host…
            !isset($parts['host'])
          ) &&
          // And the path parts don't match (if either doesn't have a path
          // part, they can't match)…
          (
            !isset($parts['path']) ||
            !isset($base_url_parts['path']) ||
            $parts['path'] !== $base_url_parts['path']
          )
        ) {
          // Add it to the list.
          $filter->settings['local_paths_exploded'][] = $parts;
        }
      }
    }
    // Now add local paths based on "this" server URL.
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path']);
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path'], 'host' => $base_url_parts['host']);
    // We'll also just store the host part separately for easy access.
    $filter->settings['base_url_host'] = $base_url_parts['host'];

    $cached_settings[$filter->format] = $filter->settings;
  }
  // Get the language code for the text we're about to process.
  $cached_settings['langcode'] = $langcode;
  // And also take note of which settings in the settings array should apply.
  $cached_settings['current_settings'] = &$cached_settings[$filter->format];

  // Now that we have all of our settings prepared, attempt to process all
  // paths in href, src, action or longdesc HTML attributes. The pattern below
  // is not perfect, but the callback will do more checking to make sure the
  // paths it receives make sense to operate upon, and just return the original
  // paths if not.
  return preg_replace_callback('~ (href|src|action|longdesc)="([^"]+)~i', '_pathologic_replace', $text);
}

/**
 * Process and replace paths. preg_replace_callback() callback.
 */
function _pathologic_replace($matches) {
  // Get the base path.
  global $base_path;

  // Get the settings for the filter. Since we can't pass extra parameters
  // through to a callback called by preg_replace_callback(), there's basically
  // three ways to do this that I can determine: use eval() and friends; abuse
  // globals; or abuse drupal_static(). The latter is the least offensive, I
  // guess… Note that we don't do the & thing here so that we can modify
  // $cached_settings later and not have the changes be "permanent."
  $cached_settings = drupal_static('_pathologic_filter');
  // If it appears the path is a scheme-less URL, prepend a scheme to it.
  // parse_url() cannot properly parse scheme-less URLs. Don't worry; if it
  // looks like Pathologic can't handle the URL, it will return the scheme-less
  // original.
  // @see https://drupal.org/node/1617944
  // @see https://drupal.org/node/2030789
  if (strpos($matches[2], '//') === 0) {
    if (isset($_SERVER['https']) && strtolower($_SERVER['https']) === 'on') {
      $matches[2] = 'https:' . $matches[2];
    }
    else {
      $matches[2] = 'http:' . $matches[2];
    }
  }
  // Now parse the URL after reverting HTML character encoding.
  // @see http://drupal.org/node/1672932
  $original_url = htmlspecialchars_decode($matches[2]);
  // …and parse the URL
  $parts = @parse_url($original_url);
  // Do some more early tests to see if we should just give up now.
  if (
    // If parse_url() failed, give up.
    $parts === FALSE
    || (
      // If there's a scheme part and it doesn't look useful, bail out.
      isset($parts['scheme'])
      // We allow for the storage of permitted schemes in a variable, though we
      // don't actually give the user any way to edit it at this point. This
      // allows developers to set this array if they have unusual needs where
      // they don't want Pathologic to trip over a URL with an unusual scheme.
      // @see http://drupal.org/node/1834308
      // "files" and "internal" are for Path Filter compatibility.
      && !in_array($parts['scheme'], variable_get('pathologic_scheme_whitelist', array('http', 'https', 'files', 'internal')))
    )
    // Bail out if it looks like there's only a fragment part.
    || (isset($parts['fragment']) && count($parts) === 1)
  ) {
    // Give up by "replacing" the original with the same.
    return $matches[0];
  }

  if (isset($parts['path'])) {
    // Undo possible URL encoding in the path.
    // @see http://drupal.org/node/1672932
    $parts['path'] = rawurldecode($parts['path']);
  }
  else {
    $parts['path'] = '';
  }

  // Check to see if we're dealing with a file.
  // @todo Should we still try to do path correction on these files too?
  if (isset($parts['scheme']) && $parts['scheme'] === 'files') {
    // Path Filter "files:" support. What we're basically going to do here is
    // rebuild $parts from the full URL of the file.
    $new_parts = @parse_url(file_create_url(file_default_scheme() . '://' . $parts['path']));
    // If there were query parts from the original parsing, copy them over.
    if (!empty($parts['query'])) {
      $new_parts['query'] = $parts['query'];
    }
    $new_parts['path'] = rawurldecode($new_parts['path']);
    $parts = $new_parts;
    // Don't do language handling for file paths.
    $cached_settings['is_file'] = TRUE;
  }
  else {
    $cached_settings['is_file'] = FALSE;
  }

  // Let's also bail out of this doesn't look like a local path.
  $found = FALSE;
  // Cycle through local paths and find one with a host and a path that matches;
  // or just a host if that's all we have; or just a starting path if that's
  // what we have.
  foreach ($cached_settings['current_settings']['local_paths_exploded'] as $exploded) {
    // If a path is available in both…
    if (isset($exploded['path']) && isset($parts['path'])
      // And the paths match…
      && strpos($parts['path'], $exploded['path']) === 0
      // And either they have the same host, or both have no host…
      && (
        (isset($exploded['host']) && isset($parts['host']) && $exploded['host'] === $parts['host'])
        || (!isset($exploded['host']) && !isset($parts['host']))
      )
    ) {
      // Remove the shared path from the path. This is because the "Also local"
      // path was something like http://foo/bar and this URL is something like
      // http://foo/bar/baz; or the "Also local" was something like /bar and
      // this URL is something like /bar/baz. And we only care about the /baz
      // part.
      $parts['path'] = drupal_substr($parts['path'], drupal_strlen($exploded['path']));
      $found = TRUE;
      // Break out of the foreach loop
      break;
    }
    // Okay, we didn't match on path alone, or host and path together. Can we
    // match on just host? Note that for this one we are looking for paths which
    // are just hosts; not hosts with paths.
    elseif ((isset($parts['host']) && !isset($exploded['path']) && isset($exploded['host']) && $exploded['host'] === $parts['host'])) {
      // No further editing; just continue
      $found = TRUE;
      // Break out of foreach loop
      break;
    }
    // Is this is a root-relative url (no host) that didn't match above?
    // Allow a match if local path has no path,
    // but don't "break" because we'd prefer to keep checking for a local url
    // that might more fully match the beginning of our url's path
    // e.g.: if our url is /foo/bar we'll mark this as a match for
    // http://example.com but want to keep searching and would prefer a match
    // to http://example.com/foo if that's configured as a local path
    elseif (!isset($parts['host']) && (!isset($exploded['path']) || $exploded['path'] === $base_path)) {
      $found = TRUE;
    }
  }

  // If the path is not within the drupal root return original url, unchanged
  if (!$found) {
    return $matches[0];
  }

  // Okay, format the URL.
  // If there's still a slash lingering at the start of the path, chop it off.
  $parts['path'] = ltrim($parts['path'],'/');

  // Examine the query part of the URL. Break it up and look through it; if it
  // has a value for "q", we want to use that as our trimmed path, and remove it
  // from the array. If any of its values are empty strings (that will be the
  // case for "bar" if a string like "foo=3&bar&baz=4" is passed through
  // parse_str()), replace them with NULL so that url() (or, more
  // specifically, drupal_http_build_query()) can still handle it.
  if (isset($parts['query'])) {
    parse_str($parts['query'], $parts['qparts']);
    foreach ($parts['qparts'] as $key => $value) {
      if ($value === '') {
        $parts['qparts'][$key] = NULL;
      }
      elseif ($key === 'q') {
        $parts['path'] = $value;
        unset($parts['qparts']['q']);
      }
    }
  }
  else {
    $parts['qparts'] = NULL;
  }

  // If we don't have a path yet, bail out.
  if (!isset($parts['path'])) {
    return $matches[0];
  }

  // If we didn't previously identify this as a file, check to see if the file
  // exists now that we have the correct path relative to DRUPAL_ROOT
  if (!$cached_settings['is_file']) {
    $cached_settings['is_file'] = !empty($parts['path']) && is_file(DRUPAL_ROOT . '/'. $parts['path']);
  }

  // Okay, deal with language stuff.
  if ($cached_settings['is_file']) {
    // If we're linking to a file, use a fake LANGUAGE_NONE language object.
    // Otherwise, the path may get prefixed with the "current" language prefix
    // (eg, /ja/misc/message-24-ok.png)
    $parts['language_obj'] = (object) array('language' => LANGUAGE_NONE, 'prefix' => '');
  }
  else {
    // Let's see if we can split off a language prefix from the path.
    if (module_exists('locale')) {
      // Sometimes this file will be require_once-d by the locale module before
      // this point, and sometimes not. We require_once it ourselves to be sure.
      require_once DRUPAL_ROOT . '/includes/language.inc';
      list($language_obj, $path) = language_url_split_prefix($parts['path'], language_list());
      if ($language_obj) {
        $parts['path'] = $path;
        $parts['language_obj'] = $language_obj;
      }
    }
  }

  // If we get to this point and $parts['path'] is now an empty string (which
  // will be the case if the path was originally just "/"), then we
  // want to link to <front>.
  if ($parts['path'] === '') {
    $parts['path'] = '<front>';
  }
  // Build the parameters we will send to url()
  $url_params = array(
    'path' => $parts['path'],
    'options' => array(
      'query' => $parts['qparts'],
      'fragment' => isset($parts['fragment']) ? $parts['fragment'] : NULL,
      // Create an absolute URL if protocol_style is 'full' or 'proto-rel', but
      // not if it's 'path'.
      'absolute' => $cached_settings['current_settings']['protocol_style'] !== 'path',
      // If we seem to have found a language for the path, pass it along to
      // url(). Otherwise, ignore the 'language' parameter.
      'language' => isset($parts['language_obj']) ? $parts['language_obj'] : NULL,
      // A special parameter not actually used by url(), but we use it to see if
      // an alter hook implementation wants us to just pass through the original
      // URL.
      'use_original' => FALSE,
    ),
  );

  // Add the original URL to the parts array
  $parts['original'] = $original_url;

  // Now alter!
  // @see http://drupal.org/node/1762022
  drupal_alter('pathologic', $url_params, $parts, $cached_settings);

  // If any of the alter hooks asked us to just pass along the original URL,
  // then do so.
  if ($url_params['options']['use_original']) {
    return $matches[0];
  }

  // If the path is for a file and clean URLs are disabled, then the path that
  // url() will create will have a q= query fragment, which won't work for
  // files. To avoid that, we use this trick to temporarily turn clean URLs on.
  // This is horrible, but it seems to be the sanest way to do this.
  // @see http://drupal.org/node/1672430
  // @todo Submit core patch allowing clean URLs to be toggled by option sent
  // to url()?
  if (!empty($cached_settings['is_file'])) {
    $cached_settings['orig_clean_url'] = !empty($GLOBALS['conf']['clean_url']);
    if (!$cached_settings['orig_clean_url']) {
      $GLOBALS['conf']['clean_url'] = TRUE;
    }
  }

  // Now for the url() call. Drumroll, please…
  $url = url($url_params['path'], $url_params['options']);

  // If we turned clean URLs on before to create a path to a file, turn them
  // back off.
  if ($cached_settings['is_file'] && !$cached_settings['orig_clean_url']) {
    $GLOBALS['conf']['clean_url'] = FALSE;
  }

  // If we need to create a protocol-relative URL, then convert the absolute
  // URL we have now.
  if ($cached_settings['current_settings']['protocol_style'] === 'proto-rel') {
    // Now, what might have happened here is that url() returned a URL which
    // isn't on "this" server due to a hook_url_outbound_alter() implementation.
    // We don't want to convert the URL in that case. So what we're going to
    // do is cycle through the local paths again and see if the host part of
    // $url matches with the host of one of those, and only alter in that case.
    $url_parts = @parse_url($url);
    if (!empty($url_parts['host']) && $url_parts['host'] === $cached_settings['current_settings']['base_url_host']) {
      $url = _pathologic_url_to_protocol_relative($url);
    }
  }

  // Apply HTML character encoding, as is required for HTML attributes.
  // @see http://drupal.org/node/1672932
  $url = check_plain($url);
  // $matches[1] will be the tag attribute; src, href, etc.
  return " {$matches[1]}=\"{$url}";
}

/**
 * Convert a full URL with a protocol to a protocol-relative URL.
 *
 * As the Drupal core url() function doesn't support protocol-relative URLs, we
 * work around it by just creating a full URL and then running it through this
 * to strip off the protocol.
 *
 * Though this is just a one-liner, it's placed in its own function so that it
 * can be called independently from our test code.
 */
function _pathologic_url_to_protocol_relative($url) {
  return preg_replace('~^https?://~', '//', $url);
}
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  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/1-propos-du-projet">1. À propos du projet</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p><strong>En bref, quel est le but global du projet&nbsp;? </strong></p>
<p>Le projet SPRINTT est axé sur la fourniture de toutes les informations et de tous les outils nécessaires à l’identification et au traitement d’une sous population spécifique de personnes âgées exposées au risque de troubles de la mobilité (perte d’autonomie) présentant des caractéristiques cliniques, biologiques et fonctionnelles précises. Plus particulièrement, SPRINTT est spécifiquement destiné à fournir une définition opérationnelle claire, objective, basée sur des données scientifiques et pertinente sur le plan clinique de la fragilité physique et de la sarcopénie (FPS). Le projet SPRINTT s’appuiera principalement sur la réalisation d’un essai clinique randomisé à grande échelle destiné à analyser l’efficacité d’une intervention à plusieurs composantes (basée sur l’activité physique, l’accompagnement nutritionnel et les technologies innovantes) par rapport à un programme d’information sur la santé destiné à prévenir les troubles de la mobilité chez les personnes âgées résidant en milieu communautaire et atteintes de FPS. Cet essai clinique fournira des informations sur les prévalences de la FPS parmi des personnes âgées en Europe et mettra à l’épreuve une stratégie inédite de prévention de l’invalidité au sein de cette population vulnérable.</p>
<p><br></p>
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  <div class="views-row views-row-2 views-row-even">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/2-quelle-probl-matique-m-dicale-de-recherche-le-projet-va-t-il-aborder">2. Quelle problématique médicale / de recherche le projet va-t-il aborder ? </a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>Une fois l’invalidité présente, la restauration d’un niveau adéquat de fonctionnement est très peu probable, particulièrement lorsque l’âge du sujet, le degré d’invalidité ou sa durée augmente. Il est donc indispensable d’anticiper l’apparition de pathologies invalidantes en ciblant les personnes âgées résidant en milieu communautaire qui ne sont pas encore victimes d’invalidité mais présentent déjà des signes&nbsp;/ symptômes préliminaires. Dans ce contexte, les maladies gériatriques associées à la fragilité (c’est à dire un syndrome multidimensionnel caractérisé par la diminution des réserves et une résistance réduite aux facteurs de stress) et à la sarcopénie (c’est à dire la perte progressive et généralisée de la masse et de la force musculosquelettiques) ont un intérêt particulier en tant que cibles des interventions de lutte contre l’invalidité et les principales conséquences négatives liées à la santé.</p>
<p>Malheureusement à ce jour, aucun programme de santé ou traitement pharmacologique n’est disponible pour les personnes âgées fragiles. Cette situation résulte en grande partie de l’absence actuelle de définition précise et universelle de la fragilité, due à la nature multidimensionnelle de la maladie. L’identification d’un fondement biologique défini (c’est à dire le déclin musculosquelettique) ouvre de nouvelles voies pour le développement de mesures visant à ralentir ou inverser la progression de la FPS (particulièrement s’agissant des pathologies invalidantes).</p>
<p>&nbsp;</p>
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  <div class="views-row views-row-3 views-row-odd">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/3-quelles-est-l-ampleur-du-probl-me">3. Quelles est l’ampleur du problème ? </a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>Selon l’étude SHARE (enquête sur la santé le vieillissement et la retraite en Europe) la prévalence de la fragilité précoce et de la fragilité chez les personnes âgées résidant en milieu communautaire est respectivement de 42,3&nbsp;% et de 17,0&nbsp;%. En l’absence d’interventions ciblées, la progression de la fragilité est associée à une morbidité accrue, l’invalidité, le recours fréquent et souvent inapproprié à des soins de santé, l’admission en établissement de soins et une mauvaise qualité de vie. Cela signifie que les pathologies invalidantes ne font pas uniquement peser un poids considérable sur la personne mais représentent aussi une menace de premier ordre sur la pérennité du système de soins de santé. La détection et la différenciation de la FPS sont donc d’une importance capitale dans la lutte contre la progression de la pathologie à risque et la prévention de ses conséquences néfastes.</p>
<p>&nbsp;</p>
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  <div class="views-row views-row-4 views-row-even">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/4-de-mani-re-g-n-rale-quels-sont-les-l-ments-n-cessaires-pour-lutter-contre-ce-probl-me">4. De manière générale, quels sont les éléments nécessaires pour lutter contre ce problème ? </a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>À ce jour, aucun programme de santé ou traitement pharmacologique n’est disponible pour les personnes âgées fragiles. Cette situation résulte en grande partie de l’absence actuelle de définition précise et universelle de la fragilité, due à la nature multidimensionnelle de la maladie. De plus, les lacunes existantes en matière de connaissances se manifestent par l’absence de mesures efficaces (pharmacologiques ou comportementales) de lutte contre la fragilité. Un tel obstacle peut être surmonté par le développement et la validation d’un cadre conceptuel solide de la fragilité permettant une opérationalisation pratique de la pathologie. Cette conceptualisation devrait également améliorer la définition des causes pathophysiologiques et cliniques de la fragilité pour aider à la conception et à la mise en œuvre d’interventions thérapeutiques spécifiques destinées à restaurer la résistance ou à retarder l’apparition d’événements indésirables (notamment l’invalidité).</p>
<p>&nbsp;</p>
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  <div class="views-row views-row-5 views-row-odd">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/5-de-quelle-fa-ce-projet-contribuera-t-il-solutionner-le-probl-me">5. De quelle façon ce projet contribuera-t-il à solutionner le problème ?</a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>Le projet SPRINTT est destiné à produire des avancées significatives dans la prise en charge des personnes âgées fragiles par la promotion d’un consensus entre le milieu universitaire, les législateurs, l’industrie et les représentants de patients sur&nbsp;:<br><br />
	(1) l’opérationalisation claire du concept actuellement vague de fragilité ;<br><br />
	(2) l’identification d’une population cible précise dont les besoins médicaux ne sont pas satisfaits ;<br><br />
	(3) l’évaluation et la validation d’une nouvelle méthodologie de déploiement en Europe de stratégies préventives et thérapeutiques parmi les personnes âgées fragiles exposées à un risque d’invalidité ;<br><br />
	(4) la définition d’un cadre expérimental servant de modèle à des fins réglementaires ainsi qu’aux investigations pharmaceutiques ;<br><br />
	(5) l’identification de biomarqueurs et de solutions technologiques de santé mobile à mettre en place dans la pratique clinique.</p>
<p>&nbsp;</p>
</div>  </div>  </div>
  <div class="views-row views-row-6 views-row-even">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/6-concr-tement-quels-sont-les-livrables-du-projet">6. Concrètement, quels sont les livrables du projet ? </a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>L’un des principaux résultats du projet sera la définition d’un cadre conceptuel de la FPS ; la mise en œuvre de ce dernier permettra d’identifier une «&nbsp;entité nosographique&nbsp;» spécifique pour les professionnels de la santé, les activités de recherche, l’industrie pharmaceutique, les législateurs et les responsables politiques.<br><br />
	Les résultats du projet SPRINTT auront donc des implications cliniques et de santé publique pertinentes, comblant un vide important en matière de connaissances pour une pratique de la médecine gériatrique basées sur des données probantes. Le but final du projet SPRINTT est de proposer des options de traitement efficaces aux personnes âgées sarcopéniques fragiles physiquement et d’améliorer leur qualité de vie.<br><br />
	Ces résultats viendront directement soutenir la pérennité et l’efficacité à long terme des systèmes de soins de santé et de services sociaux.<br><br />
	L’un des principaux résultats du projet sera la définition d’un cadre conceptuel de la FPS&nbsp;; la mise en œuvre de ce dernier permettra d’identifier une «&nbsp;entité nosographique&nbsp;» spécifique pour les professionnels de la santé, les activités de recherche, l’industrie pharmaceutique, les législateurs et les responsables politiques.<br><br />
	Les résultats du projet SPRINTT auront donc des implications cliniques et de santé publique pertinentes, comblant un vide important en matière de connaissances pour une pratique de la médecine gériatrique basées sur des données probantes. Le but final du projet SPRINTT est de proposer des options de traitement efficaces aux personnes âgées sarcopéniques fragiles physiquement et d’améliorer leur qualité de vie. Ces résultats viendront directement soutenir la pérennité et l’efficacité à long terme des systèmes de soins de santé et de services sociaux.</p>
<p>&nbsp;</p>
</div>  </div>  </div>
  <div class="views-row views-row-7 views-row-odd">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/7-pourquoi-un-partenariat-priv-et-public-de-l-imi-est-il-n-cessaire-pour-y-parvenir">7. Pourquoi un partenariat privé et public de l’IMI est-il nécessaire pour y parvenir ? </a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>Dans le but de définir un risque convenu, scientifiquement robuste et cliniquement pertinent comme le concept proposé pour la FPS, il est nécessaire que toutes les parties prenantes impliquées dans la prévention et les soins aux personnes âgées (par exemple le milieu universitaire, les industries pharmaceutiques, les experts en bioéthique, les économistes spécialisés dans la santé publique et les représentants de patients) puissent apporter leurs expertise et recommandations. Ce n’est que par une collaboration étroite entre les partenaires publics et privés que la production de résultats sera possible, des résultats non seulement solides scientifiquement mais également précurseurs au futur déploiement clinique (dans la pratique clinique courante) et au développement de traitement pharmacologiques&nbsp;/ biologiques innovants.</p>
<p>&nbsp;</p>
</div>  </div>  </div>
  <div class="views-row views-row-8 views-row-even">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/8-de-quelle-fa-le-projet-favorisera-t-il-la-comp-titivit-du-secteur-pharmaceutique-en-europe">8. De quelle façon le projet favorisera-t-il la compétitivité du secteur pharmaceutique en Europe ? </a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>Les résultats générés par le projet SPRINTT fourniront la preuve nécessaire permettant d’identifier de façon certaine un segment de la population de personnes âgées exposée à un risque de conséquences indésirables et dont les besoins médicaux ne sont à ce jour pas satisfaits, en partie à cause de l’imprécision de la définition actuelle de la fragilité. L’identification d’un fondement biologique défini sous-jacent à la fragilité (c’est à dire le déclin musculosquelettique) ouvre de nouvelles voies de recherche et de développement de mesures spécifiquement destinées à ralentir ou à inverser la progression de la pathologie FPS à l’étude (particulièrement en ce qui concerne les pathologies invalidantes). L’évaluation réglementaire des résultats de l’essai clinique (données générées pendant le projet) favorisera la mise au point de médicaments innovants pour le traitement de la FPS, en apportant un cadre de référence et des méthodologies partagées.</p>
<p>&nbsp;</p>
</div>  </div>  </div>
  <div class="views-row views-row-9 views-row-odd">
      
  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/9-quels-sont-les-domaines-d-expertise-cl-s-repr-sent-s-dans-le-consortium">9. Quels sont les domaines d’expertise clés représentés dans le consortium ? </a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>Le consortium est composé d’experts reconnus à l’échelle internationale dans le domaine de la fragilité et de la sarcopénie. La nature multidimensionnelle de la FPS nécessite la création d’un consortium caractérisé par des expertises et des antécédents multiples. Pour cette raison, les domaines d’expertise clés suivants peuvent être représentés au sein du projet SPRINTT,&nbsp;:</p>
<ul>
<li style="margin-left: 18pt;">Gériatrie</li>
<li style="margin-left: 18pt;">Gérontologie</li>
<li style="margin-left: 18pt;">Évaluation des technologies de santé</li>
<li style="margin-left: 18pt;">Bioéthique</li>
<li style="margin-left: 18pt;">Biomarqueurs du vieillissement</li>
<li style="margin-left: 18pt;">Physiologie musculaire</li>
<li style="margin-left: 18pt;">Nutrition</li>
<li style="margin-left: 18pt;">Statistiques</li>
<li style="margin-left: 18pt;">Méthodologies inédites d’essai clinique (particulièrement appliquées aux essais cliniques chez les personnes âgées)</li>
<li style="margin-left: 18pt;">Médecine préventive</li>
<li style="margin-left: 18pt;">Technologie de l’information et de la communication, notamment la santé mobile</li>
<li style="margin-left: 18pt;">Pratique d’exercices physiques (particulièrement adaptée aux personnes âgées)</li>
<li style="margin-left: 18pt;">Sciences réglementaires</li>
<li style="margin-left: 18pt;">Évaluation gériatrique globale</li>
<li style="margin-left: 18pt;">Vieillissement</li>
<li style="margin-left: 18pt;">Fonction physique</li>
<li style="margin-left: 18pt;">Invalidité physique</li>
<li style="margin-left: 18pt;">Mobilité</li>
</ul>
<p><br></p>
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  <div class="views-field views-field-title">        <span class="field-content"><a href="/fr/10-quels-autres-l-ments-singularisent-ce-projet">10. Quels autres éléments singularisent ce projet ? </a></span>  </div>  
  <div class="views-field views-field-body">        <div class="field-content"><p>La conceptualisation de la FPS telle que proposée par le projet SPRINTT favorisera d’importantes avancées par rapport aux approches traditionnelles en permettant l’opérationalisation précise de la maladie, l’identification claire de la population touchée et la transposition rapide de ces découvertes dans la sphère clinique.</p>
<p>L’intervention proposée dans l’essai SPRINT-T est inédite (bien que basée sur des antécédents et des données solides, une interventions à plusieurs composantes visant à lutter contre l’apparition de troubles de la mobilité n’a jamais été testée à grande échelle), nécessaire (elle cible des pathologies observées fréquemment chez les personnes âgées résidant en milieu communautaire en Europe), pertinente (elle est axée sur la fonction, principal facteur définissant la qualité de vie et paramètre le plus important chez les personnes âgées), facilement applicable au niveau de la population (facilitant de ce fait la future mise en place de ses découvertes) et évolutive (elle prévoit de valider des services technologiques de santé et des infrastructures TIC permettant l’acquisition&nbsp;/ l’analyse des données, la prise de décision clinique et l’accessibilité aux mesures depuis la domicile du patient, et ce de façon optimale).</p>
<p>L’essai contrôlé randomisé qui doit être mené dans le cadre des activités du projet SPRINTT représentera la plus vaste étude d’Europe visant à déterminer la possibilité de prévenir l’invalidité en ciblant des facteurs de risque spécifiques (c’est à dire la FPS). Parallèlement, l’essai offrira indirectement l’occasion d’identifier les personnes âgées atteintes de FPS susceptibles de ne pas répondre aux modifications bénéfiques du style de vie, permettant ainsi d’identifier les individus qui peuvent d’avoir besoin d’un traitement supplémentaire afin de prévenir&nbsp;/ inverser le processus d’invalidité. Les données générées permettront la réalisation d’une recherche clinique secondaire et fourniront une base solide à un consensus scientifique et réglementaire au-delà de l’Europe, par le biais de méta analyses impliquant des programmes de recherche parallèles déployés dans d’autres régions du monde.</p>
<p>Le consortium SPRINTT est composé de partenaires issus de plus de 20 institutions publiques et privées réparties dans plus de 11 pays européens.</p>
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