For Researchers

Beneficial Effects of Leucine Supplementation on Criteria for Sarcopenia: A Systematic Review

F.M. Martínez-Arnau, R. Fonfría-Vivas, O. Cauli

Nutrients. 2019 Oct 17;11(10)

Treating sarcopenia remains a challenge, and nutritional interventions present promising approaches. We summarize the effects of leucine supplementation in treating older individuals with sarcopenia associated with aging or to specific disorders, and we focus on the effect of leucine supplementation on various sarcopenia criteria, e.g., muscular strength, lean mass, and physical performance.

The inter-relationship between marginal vitamin D deficiency and muscle

V. Kamwa, Z.K. Hassan-Smith

Curr Opin Endocrinol Diabetes Obes. 2019 Sep 30. doi: 10.1097/MED.0000000000000504. [Epub ahead of print]

The aim is to review the recent literature on the interplay between mild vitamin D deficiency and skeletal muscle strength and performance.

Sarcopenia: A Time for Action. An SCWD Position Paper

J. Bauer, J.E. Morley, A.M.W.J. Schols, et al.

J Cachexia Sarcopenia Muscle. 2019 Sep 15. doi: 10.1002/jcsm.12483. [Epub ahead of print]

There is a need for more clinical research into the appropriate measurement for muscle mass and the management of sarcopenia. Accordingly, this position statement provides recommendations on the management of sarcopenia and how to progress the knowledge and recognition of sarcopenia.

Differentially methylated gene patterns between age-matched sarcopenic and non-sarcopenic women

L. He, P. Khanal, C.I. Morse, A. Williams, et al.

J Cachexia Sarcopenia Muscle. 2019 Sep 11. doi: 10.1002/jcsm.12478. [Epub ahead of print]

Sarcopenia is characterized by progressive decreases in muscle mass, muscle strength, and muscle function with ageing. Although many studies have investigated the mechanisms of sarcopenia, its connection with epigenetic factors, such as DNA methylation, still remains poorly understood. The aim of this study was to explore sarcopenia-related DNA methylation differences in blood samples between age-matched sarcopenic and non-sarcopenic older women.

Tai Chi and whole-body vibrating therapy in sarcopenic men in advanced old age: a clinical randomized controlled trial

Y.Q. Zhu, N. Peng, M. Zhou, et al.

Eur J Ageing. 2019;16(3):273-282

This study was to investigate the effects of Tai Chi (TC) and whole-body vibration (WBV) exercise in sarcopenic men in advanced old age.

Apolipoprotein ε4 allele is associated with frailty syndrome: results from the hellenic longitudinal investigation of ageing and diet study

N. Mourtzi, E. Ntanasi, M. Yannakoulia, et al.

Age Ageing. 2019 Aug 23. pii: afz098. doi: 10.1093/ageing/afz098. [Epub ahead of print]

Apolipoprotein (APOE) ε4 allele has been associated with a number of age-related diseases but previous studies failed to identify any link with Frailty syndrome. The aim of the present study is to investigate the association between APOE ε4 allele and frailty syndrome.