For Researchers

Inflammatory biomarkers of frailty

M. Vatic, S. von Haehling, N. Ebner

Exp Gerontol. 2020;133:110858. doi: 10.1016/j.exger.2020.110858. Epub 2020 Jan 31.

This review summarizes the present knowledge of inflammatory biomarkers that are considered promising tools to evaluate frailty.

ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty

L. Rodriguez-Mañas, I. Araujo de Carvalho, S. Bhasin,et al.

J Frailty Aging. 2020;9(1):4-8. doi: 10.14283/jfa.2019.32.

The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - a group of academic and industry scientists from around the world -- met in February 2019 to discuss the current state of biomarker development for frailty and sarcopenia.

Sarcoscore: A Novel Approach for Assessing Sarcopenia and Functional Disability in Older Adults

Y. Osuka, H. Kim, H. Kawai,et al.

J Clin Med. 2020;9(3). pii: E692. doi: 10.3390/jcm9030692.

We developed an index for assessing sarcopenia degree (sarcoscore) and compared it to the Asian Working Group for Sarcopenia (AWGS) criteria.

Circulating Interleukin-6 Is Associated with Skeletal Muscle Strength, Quality, and Functional Adaptation with Exercise Training in Mobility-Limited Older Adults

G.J Grosicki, B.B. Barrett, D.A. Englund,et al.

J Frailty Aging. 2020;9(1):57-63. doi: 10.14283/jfa.2019.30.

The aim was to investigate relationships between circulating IL-6, skeletal muscle health and exercise adaptation in mobility-limited older adults.

Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium

S. Bhasin, T.G. Travison, T.M. Maniniz, et al.

J Am Geriatr Soc. 2020 Mar 9. doi: 10.1111/jgs.16372. [Epub ahead of print]

The aim was to develop an evidence-based definition of sarcopenia that can facilitate identification of older adults at risk for clinically relevant outcomes (eg, self-reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition and Outcomes Consortium (SDOC) crafted a set of position statements informed by a literature review and SDOC's analyses of eight epidemiologic studies, six randomized clinical trials, four cohort studies of special populations, and two nationally representative population-based studies.

The Tilburg Frailty Indicator (TFI): New Evidence for Its Validity

R.J. Gobbens, P. Boersma, I. Uchmanowicz, et al.

Clin Interv Aging. 2020;15:265-274

The Tilburg Frailty Indicator (TFI) is a self-report user-friendly questionnaire for assessing multidimensional frailty among community-dwelling older people. The main aim of this study is to re-evaluate the validity of the TFI, both cross-sectionally and longitudinally, focusing on the predictive value of the total TFI and its physical, psychological, and social domains for adverse outcomes disability, indicators of healthcare utilization, and falls.