For Researchers
H. Makizako, Y. Nakai, K. Tomioka, et al.J Clin Med. 2020 May 8;9(5):E1386. doi: 10.3390/jcm9051386. This study aimed to assess the effects of a multicomponent exercise program on physical function and muscle mass in older adults with sarcopenia or pre-sarcopenia. Moreover, we aim to standardize the exercise program for easy incorporation in the daily life of community-dwelling older adults as a secondary outcome. |
Y.D. Liang, Q. Liu, M.H. Du, et al.Free Radic Biol Med. 2020 Mar 23;152:248-254. doi: 10.1016/j.freeradbiomed.2020.03.011. [Epub ahead of print] The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) in urine are two aging biomarkers that have not been explored deeply in cases of frailty. |
A. Picca, R. Beli, R. Calvani, et al.Cells. 2020 Apr 15;9(4). pii: E973. doi: 10.3390/cells9040973. Mitochondrial dysfunction and systemic inflammation are major factors in the development of sarcopenia, but the molecular determinants linking the two mechanisms are only partially understood. The study of extracellular vesicle (EV) trafficking may provide insights into this relationship. |
M.D. Witham, M. Chawner, S. Biase, et al.J Frailty Sarcopenia Falls. 2020 Mar 1;5(1):17-23. doi: 10.22540/JFSF-05-017. eCollection 2020 Mar. The aim was to establish whether existing exercise programmes offered to people with sarcopenia or frailty adhere to the current evidence base. |
S. Jiang, L. Kang, M. Zhu, et al.Arch Gerontol Geriatr. 2020 Feb 25;88:104038. doi: 10.1016/j.archger.2020.104038. [Epub ahead of print] The aim was to evaluate whether urinary 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), a biomarker of RNA oxidative damage, was independently associated with frailty. |
Q. Xiao, M. Wu, J. Cui, et al.BMC Geriatr. 2020 Apr 6;20(1):126. doi: 10.1186/s12877-020-01523-w. Vitamin D deficiency has been linked to the risk of frailty. However, there are limited methods for evaluations of the potential association of vitamin D with frailty in a longevous (80+) population. The aim of this study was to examine the association between plasma 25-hydroxyvitamin D [25(OH)D] levels and the risk of frailty among the Chinese community based oldest-old. |