For Healthcare Providers

Exploring the potential of salivary and blood immune biomarkers to elucidate physical frailty in institutionalized older women

G.E. Furtado, M. Uba Chupel, L. Minuzzi, et al.

Exp Gerontol. 2020;129:110759. doi: 10.1016/j.exger.2019.110759. Epub 2019 Oct 31.

Identification of older populations at increased risk of physical frailty using biochemical approaches could improve screening accuracy. The aim of this study was to study the relationship between immune markers and independent components of physical frailty in institutionalized older women.

The impact of frailty on healthcare resource use: a longitudinal analysis using the Clinical Practice Research Datalink in England

L. Han, A. Clegg, T. Doran, et al.

Age Ageing. 2019 ;48(5):665-671. doi: 10.1093/ageing/afz088.

Routine frailty identification and management is national policy in England, but there remains a lack of evidence on the impact of frailty on healthcare resource use. We evaluated the impact of frailty on the use and costs of general practice and hospital care.

The accumulation of deficits approach to describe frailty

R. Lachmann, M. Stelmach-Mardas, M.M. Bergmann, et al.

PLoS One. 2019 Oct 15;14(10):e0223449. doi: 10.1371/journal.pone.0223449. eCollection 2019

The advancing age of the participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study was the incentive to investigate frailty as a major parameter of ageing. The aim of this study was to develop a multidimensional tool to measure frailty in an ageing, free-living study population.

Dose-response association between physical activity and sedentary time categories on ageing biomarkers

A. Mañas, B. Del Pozo-Cruz, I. Rodríguez-Gómez, et al.

BMC Geriatr. 2019;19(1):270

Physical activity and sedentary behaviour have been suggested to independently affect a number of health outcomes. To what extent different combinations of physical activity and sedentary behaviour may influence physical function and frailty outcomes in older adults is unknown. The aim of this study was to examine the combination of mutually exclusive categories of accelerometer-measured physical activity and sedentary time on physical function and frailty in older adults.

Beneficial Effects of Leucine Supplementation on Criteria for Sarcopenia: A Systematic Review

F.M. Martínez-Arnau, R. Fonfría-Vivas, O. Cauli

Nutrients. 2019 Oct 17;11(10)

Treating sarcopenia remains a challenge, and nutritional interventions present promising approaches. We summarize the effects of leucine supplementation in treating older individuals with sarcopenia associated with aging or to specific disorders, and we focus on the effect of leucine supplementation on various sarcopenia criteria, e.g., muscular strength, lean mass, and physical performance.

Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management

E. Dent, J.E. Morley, A.J. Cruz-Jentoft, et al.

J Nutr Health Aging. 2019;23(9):771-787

The task force of the International Conference of Frailty and Sarcopenia Research (ICFSR) developed these clinical practice guidelines to overview the current evidence-base and to provide recommendations for the identification and management of frailty in older adults.