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Frailty Is Associated with an Increased Risk of Incident Type 2 Diabetes in the Elderly.

N. Veronese, B. Stubbs, L. Fontana et al.

J Am Med Dir Assoc. 2016 Jun 7. pii: S1525-8610(16)30115-3. doi: 10.1016/j.jamda.2016.04.021. [Epub ahead of print]

This longitudinal study (follow-up of 4.4 years) aimed to investigate whether frailty is associated with an increased risk of incident type 2 diabetes mellitus (T2DM) in a prospective cohort of community-dwelling older people. Among community-dwelling older people, frailty and prefrailty were significant and independent predictors of T2DM, which is a major and potentially preventable risk factor for multiple comorbidities.

Case finding for sarcopenia in geriatric inpatients: performance of bioimpedance analysis in comparison to dual X-ray absorptiometry

J. Reiss, B. Iglseder, M. Kreutzer et al.

BMC Geriatr. 2016;16(1):52

The European Working Group on Sarcopenia in Older People (EWGSOP) suggests different methods for case finding for sarcopenia. However, data comparing the different methodological options are scarce for geriatric inpatients. Muscle mass measured by BIA was highly correlated to DXA (r > 0.9), but BIA systematically overestimated muscle mass. The raw agreement between the DXA- and BIA-based approaches for classifying participants as having normal or reduced muscle mass was at best 80 % depending on the BIA cut-offs used.

Prediction of one-year mortality by five different frailty instruments: A comparative study in hospitalized geriatric patients.

M. Ritt, L.C. Bollheimer, C.C. Sieber et al.

Arch Gerontol Geriatr. 2016;66:66-72.

307 patients ≥65years who were hospitalized in geriatric wards were included in this prospective analysis. A fifty-item frailty index (FI), a ten-domain+co-morbidity frailty index based on a standardized comprehensive geriatric assessment (FI-CGA), the nine category Clinical Frailty Scale (CFS-9), the CSHA rules-based frailty definition (CSHA-RBFD), and the frailty phenotype (FP) were assessed during the patients' hospital stays. Among those frailty instruments that were evaluated, the CFS-9 emerged as the most powerful for prediction of one-year mortality.

Frailty as a predictor of fractures among community-dwelling older people: A systematic review and meta-analysis.

G. Kojima

Bone. 2016;90:116-122.

This systematic review and meta-analysis showed evidence that pre-frailty and frailty are significant predictors of fractures among community-dwelling older people.

Emergency general surgery specific frailty index: A validation study.

T.O. Jokar, K. Ibraheem , P. Rhee et al.

J Trauma Acute Care Surg. 2016 May 27. [Epub ahead of print]

Assessment of operative risk in geriatric patients undergoing emergency general surgery (EGS) is challenging. Frailty is an established measure for risk assessment in surgical cases. The aim of our study was to validate a modified 15 variable emergency general surgery specific frailty index (EGSFI). Data obtained suggest that the 15-variable validated EGSFI is a simple and reliable bedside tool to determine the frailty status of patients undergoing emergency general surgery.

Serum markers of inflammation and oxidative stress in sarcopenia.

B. Can, O. Kara, M.C. Kizilarslanoglu et al.

Aging Clin Exp Res. 2016 Aug 29. [Epub ahead of print]

The aim of the study was to evaluate the relationship between sarcopenia and biomarkers that may be involved in its pathogenesis and hence allow early detection.
The present study demonstrated an association of sarcopenia with inflammatory markers CRP, erythrocyte sedimentation rate and adiponectin.

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