Dla naukowców

Serum Sestrins: Potential Predictive Molecule in Human Sarcopenia

S.P. Rajan, M. Anwar, B. Jain, et al.

Aging Clin Exp Res. 2020 Jun 27. doi: 10.1007/s40520-020-01642-9.

The study aims to identify sarcopenia in older adults using Asian Working group guidelines (AWGS) to determine clinically relevant cut-off levels for diagnosis and their association with antioxidant protein Sesns.

Association Between Dietary Habits and Physical Function in Brazilian and Italian Older Women

H.J. Coelho-Junior, R. Calvani, A. Picca, et al.

Nutrients. 2020 Jun 1;12(6):E1635. doi: 10.3390/nu12061635.

The present study investigated and compared the patterns of dietary protein intake and physical function in Brazilian and Italian older women.

Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy

S. Mankhong, S. Kim, S. Moon, et al.

Cells . 2020 Jun 2;9(6):E1385. doi: 10.3390/cells9061385.

In this article we describe the fundamental aging mechanisms. Next, e discuss both in vitro and in vivo experimental models based on molecular mechanisms that have the potential to elucidate the biochemical processes integral to sarcopenia. Lastly, we discuss the possible molecular targets and the current status of drug candidates for sarcopenia treatment.

Muscle Mass, Muscle Strength, and Physical Performance in Older People: An Umbrella Review of Systematic Reviews and Meta-Analyses

E. Gielen, D. Beckwée, A. Delaere, et al.

Nutr Rev. 2020;nuaa011. doi:10.1093/nutrit/nuaa011.

The aim of this umbrella review was to provide an evidence-based overview of nutritional interventions targeting sarcopenia or at least 1 of the 3 sarcopenia criteria (ie, muscle mass, muscle strength, or physical performance) in persons aged ≥ 65 years.

Effects of a Multicomponent Exercise Program in Physical Function and Muscle Mass in Sarcopenic/Pre-Sarcopenic Adults

H. Makizako, Y. Nakai, K. Tomioka, et al.

J Clin Med. 2020 May 8;9(5):E1386. doi: 10.3390/jcm9051386.

This study aimed to assess the effects of a multicomponent exercise program on physical function and muscle mass in older adults with sarcopenia or pre-sarcopenia. Moreover, we aim to standardize the exercise program for easy incorporation in the daily life of community-dwelling older adults as a secondary outcome.

Urinary 8-oxo-7,8-dihydroguanosine as a potential biomarker of frailty for elderly patients with cardiovascular disease

Y.D. Liang, Q. Liu, M.H. Du, et al.

Free Radic Biol Med. 2020 Mar 23;152:248-254. doi: 10.1016/j.freeradbiomed.2020.03.011. [Epub ahead of print]

The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) in urine are two aging biomarkers that have not been explored deeply in cases of frailty.

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