Pour les chercheurs

High flavonoid cocoa supplement ameliorates plasma oxidative stress and inflammation levels while improving mobility and quality of life in older subjects: a double blind randomized clinical trial

L. Munguia, I. Rubio-Gayosso, I. Ramirez-Sanchez, et al.

J Gerontol A Biol Sci Med Sci. 2019 May 6. pii: glz107. doi: 10.1093/gerona/glz107. [Epub ahead of print]

The age-related decline in mass, strength and performance of skeletal muscle is associated with loss of independence, falls risk, disability, institutionalization and death.

To determine whether a cocoa supplement enriched in flavonoids can improve plasma markers of oxidative stress and inflammation, physical performance and frailty in middle and older age subjects, we conducted a two-phase, randomized, double blind, clinical trial.

Effects of dietary patterns and low protein intake on sarcopenia risk in the very old: The Newcastle 85+ study

A. Granic, N. Mendonça, A.A. Sayer, et al.

Clin Nutr. 2019 Jan 21. pii: S0261-5614(19)30011-1. doi: 10.1016/j.clnu.2019.01.009. [Epub ahead of print]

The aim was to investigate the association between healthy dietary patterns DPs and the risk of sarcopenia over 3 years, and to determine whether protein intake influences this relationship in community-dwelling older adults from the Newcastle 85 + Study.

Higher protein intake is associated with a lower likelihood of frailty among older women, Kuopio OSTPRE-Fracture Prevention Study

M. Isanejad, J. Sirola, T. Rikkonen, et al.

Eur J Nutr. 2019 May 7. doi: 10.1007/s00394-019-01978-7. [Epub ahead of print]

Nordic nutrition recommendations (2012) suggest protein intake ≥ 1.1 g/kg body weight (BW) to preserve physical function in Nordic older adults. However, no published study has used this cut-off to evaluate the association between protein intake and frailty. This study examined associations between protein intake, and sources of protein intake, with frailty status at the 3-year follow-up.

Associations between dietary patterns at age 71 and the prevalence of sarcopenia 16 years later

M. Karlsson, W. Becker, K. Michaëlsson, et al.

Clin Nutr. 2019 Apr 18. pii: S0261-5614(19)30182-7. doi: 10.1016/j.clnu.2019.04.009. [Epub ahead of print]

The growing recognition of the significance of sarcopenia has highlighted the need to understand etiologic factors, where food intake likely plays a role. The aim was to investigate the association between dietary patterns at mean age 71 and the prevalence of sarcopenia at mean age 87 in a Swedish cohort of community dwelling men.

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study

K. Liberman, R. Njemini, Y. Luiking, et al.

Aging Clin Exp Res. 2019 May 2. doi: 10.1007/s40520-019-01208-4. [Epub ahead of print]

A chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited. The aim was to investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis.

Sex-specific differences in the association of vitamin D with low lean mass and frailty: Results from the Berlin Aging Study II

D. Spira, N. Buchmann, M. König, et al.

Nutrition. 2019;62:1-6

Sex-specific differences in factors associated with aging and lifespan, such as sarcopenia and disease development, are increasingly recognized. The study aims to assess sex-specific aspects of the association between vitamin D insufficiency and low lean mass as well as between vitamin D insufficiency and the frailty phenotype.

Pages