For Researchers

Changes in frailty status in a community-dwelling cohort of older adults: The VERISAÚDE study

L. Lorenzo-López, R. López-López, A. Maseda, et al.

Maturitas. 2019;119:54-60

Greater understanding of changes in the degree of frailty is important for clarifying the natural history of frailty and may help clinical decision-making regarding preventive interventions. The objectives of this study were to explore natural frailty transition rates at 1-year follow-up and to identify the main determinants of such transitions.

Systemic and Metabolic Signature of Sarcopenia in Community-Dwelling Older Adults

Y. Lu, L.G. Karagounis, T.P. Ng, et al.

J Gerontol A Biol Sci Med Sci. 2019 Jan 8. doi: 10.1093/gerona/glz001. [Epub ahead of print]

The present cross-sectional study characterized the nutritional and metabolic profile of sarcopenia through an extensive exploration of a wide array of blood biomarkers related to muscle protein metabolism and transcriptomic signatures in community-dwelling elderly.

Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise

A. Picca, R. Calvani, C. Leeuwenburgh, et al.

Expert Opin Ther Targets. 2019;23(2):153-160

We discuss the evidence that points to mitochondrial dysfunction having a causative role in sarcopenia and the mechanisms involved in the accumulation of damaged mitochondria in the aged muscle. We also discuss the effects of physical exercise on mitochondrial quality control and muscle health in advanced age.

Serum Myostatin Levels Are Higher in Fitter, More Active, and Non-Frail Long-Term Nursing Home Residents and Increase after a Physical Exercise Intervention

H. Arrieta, G. Hervás, C. Rezola-Pardo, et al.

Gerontology. 2018 Nov 21:1-11. doi: 10.1159/000494137. [Epub ahead of print]

The aim is to determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and frailty in long-term nursing home residents. We also aimed to ascertain the effect of an exercise program on myostatin levels.

Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case

C. Mast, D. Dardevet, I. Papet

Nutr Res Rev. 2018;31(2):179-192

The present review provides the rationale for the potential pro-sarcopenic effect of paracetamol (acetaminophen; APAP) then recent results concerning the effect of chronic APAP treatment on muscle mass and metabolism are discussed.

Understanding functional and social risk characteristics of frail older adults: a cross-sectional survey study

D.R. Lee, E.C. Santo, J.C. Lo, et al.

BMC Fam Pract. 2018;19(1):170

Frailty is a condition of increasing importance, given the aging adult population. With an anticipated shortage of geriatricians, primary care physicians will increasingly need to manage care for frail adults with complex functional risks and social-economic circumstances.