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Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

A. Santoro, G. Guidarelli, R. Ostan, et al.

Eur Radiol. 2019 Feb 4. doi: 10.1007/s00330-018-5973-2. [Epub ahead of print]

The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.

Prospective Views for Whey Protein and/or Resistance Training Against Age-related Sarcopenia

Y. Liao, Z. Peng, L. Chen, et al.

Aging Dis. 2019;10(1):157-173

Whey protein and/or resistance training has shown promise in preventing and treating age-related sarcopenia. Sex hormones could be potential contributors for gender differences in skeletal muscle and age-related sarcopenia. In addition, skeletal muscle and the development of sarcopenia are influenced by gut microbiota.

Biological Processes and Biomarkers Related to Frailty in Older Adults: A State-of-the-Science Literature Review

J. Wang, C.A. Maxwell, F. Yu

Biol Res Nurs. 2019;21(1):80-106

The objectives of this literature review were to (1) synthesize biological processes linked to frailty and their corresponding biomarkers and (2) identify potential associations among these processes and biomarkers.

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

D.D. Huang, S.D. Fan, X.Y. Chen, et al.

Exp Gerontol. 2019 Jan 25. pii: S0531-5565(18)30615-6. doi: 10.1016/j.exger.2019.01.022. [Epub ahead of print]

Mitochondrial dysfunction during aging is a key factor that contributes to sarcopenia. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been increasingly recognized to regulate mitochondrial function. The present study aimed to investigate the role of Nrf2 in the development of frailty and sarcopenia during aging, and to demonstrate whether Nrf2 contributes to the maintenance of muscle mass and function by regulation of mitochondrial biogenesis and dynamics during the aging process.

Relationship between nutritional status and frailty in hospitalized older patients

X. Hong, J. Yan, L. Xu, et al.

Clin Interv Aging. 2019;14:105-111

The definition of frailty still lacks quantitative biomarkers. This study aimed to investigate the relationship between nutrition-related biomarkers and frailty in hospitalized older patients.

Epidemiology of Sarcopenia and Factors Associated With It Among Community-Dwelling Older Adults in Taiwan

Y.H. Kuo, T.F. Wang, L.K. Liu, et al.

Am J Med Sci. 2019;357(2):124-133

Sarcopenia is a well-recognized geriatric syndrome. We sought to determine the prevalence of sarcopenia and factors associated with it among community-dwelling older adults in Taiwan.