For Researchers

Serum Myostatin Levels Are Higher in Fitter, More Active, and Non-Frail Long-Term Nursing Home Residents and Increase after a Physical Exercise Intervention

H. Arrieta, G. Hervás, C. Rezola-Pardo, et al.

Gerontology. 2018 Nov 21:1-11. doi: 10.1159/000494137. [Epub ahead of print]

The aim is to determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and frailty in long-term nursing home residents. We also aimed to ascertain the effect of an exercise program on myostatin levels.

Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case

C. Mast, D. Dardevet, I. Papet

Nutr Res Rev. 2018;31(2):179-192

The present review provides the rationale for the potential pro-sarcopenic effect of paracetamol (acetaminophen; APAP) then recent results concerning the effect of chronic APAP treatment on muscle mass and metabolism are discussed.

Understanding functional and social risk characteristics of frail older adults: a cross-sectional survey study

D.R. Lee, E.C. Santo, J.C. Lo, et al.

BMC Fam Pract. 2018;19(1):170

Frailty is a condition of increasing importance, given the aging adult population. With an anticipated shortage of geriatricians, primary care physicians will increasingly need to manage care for frail adults with complex functional risks and social-economic circumstances.

Dysregulated homeostatic pathways in sarcopenia among frail older adults

T.P. Ng, Y. Lu, R.W.M. Choo, et al.

Aging Cell. 2018 Oct 9:e12842. doi: 10.1111/acel.12842. [Epub ahead of print]

Sarcopenia, a core feature of the physical frailty syndrome, is characterized by multisystem physiological dysregulation. No study has explored qualitatively the hierarchical network of relationships among different dysregulated pathways involved in the pathogenesis of sarcopenia.

Low vitamin intake is associated with risk of frailty in older adults

T. Balboa-Castillo, E.A. Struijk, E. Lopez-Garcia, et al.

Age Ageing. 2018;47(6):872-879

The association between vitamin intake and frailty has hardly been studied. The objective was to assess the association of dietary vitamin intake with incident frailty in older adults from Spain.

Evaluation of appendicular lean mass using bio impedance in persons aged 80+: A new equation based on the BUTTERFLY-study

S. Vermeiren, D. Beckwée, R. Vella-Azzopardi, et al.

Clin Nutr. 2018 Aug 2. pii: S0261-5614(18)31240-8. doi: 10.1016/j.clnu.2018.07.029. [Epub ahead of print]

To date, the accuracy of bio-impedance (BIA) to assess body composition & sarcopenia in persons aged 80 and over remains unclear.

We aimed to evaluate the agreement between dual energy X-ray absorptiometry (DXA) and BIA equations to determine lean mass, as well as their suitability to identify sarcopenia.