For Researchers

Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men

A.M. Holwerda, K.J.M. Paulussen, M. Overkamp, et al.

Am J Physiol Endocrinol Metab. 2019 May 21. doi: 10.1152/ajpendo.00073.2019. [Epub ahead of print]

We investigated whether co-ingestion of 1.5 g free leucine with a single, 15 g bolus of protein further augments the post-prandial muscle protein synthetic response during recovery from resistance-type exercise in older men.

Consequences of applying the new EWGSOP2 guideline instead of the former EWGSOP guideline for sarcopenia case finding in older patients

J. Reiss, B. Iglseder, R. Alzner, et al.

Age Ageing. 2019 May 21. pii: afz035. doi: 10.1093/ageing/afz035. [Epub ahead of print]

We examined the consequences of applying the new EWGSOP2 algorithm for sarcopenia screening instead of the former EWGSOP algorithm (EWGSOP1) in geriatric inpatients.

Smoking and Diabetes as Predictive Factors of Accelerated Loss of Muscle Mass in Middle-Aged and Older Women: A Six-Year Retrospective Cohort Study

N. Lee, C.J. Choi

J Womens Health (Larchmt). 2019 May 23. doi: 10.1089/jwh.2018.7527. [Epub ahead of print]

Preservation of muscle mass during aging reduces the risk of frailty and age-related chronic diseases. We investigated the lifestyle, psychological factors, and common cardiometabolic diseases associated with accelerated muscle loss in middle-aged and older women.

Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project

B. Hsu, V. Hirani, R.G. Cumming, et al.

J Gerontol A Biol Sci Med Sci. 2019;74(6):835-841

Previous studies demonstrated associations between interleukin-6 (IL-6) and frailty, but associations between a wide range of cytokines, chemokines, and growth factors with prevalent and incident frailty has not been studied.

Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty "cytokinome" at its core

E. Marzetti, A. Picca, F. Marini, et al.

Exp Gerontol. 2019;122:129-138

This study was designed to explore the association between a large panel of inflammatory biomolecules and physical frailty and sarcopenia in older adults through a multivariate statistical approach. Gender-specific inflammatory patterns were also explored.

High flavonoid cocoa supplement ameliorates plasma oxidative stress and inflammation levels while improving mobility and quality of life in older subjects: a double blind randomized clinical trial

L. Munguia, I. Rubio-Gayosso, I. Ramirez-Sanchez, et al.

J Gerontol A Biol Sci Med Sci. 2019 May 6. pii: glz107. doi: 10.1093/gerona/glz107. [Epub ahead of print]

The age-related decline in mass, strength and performance of skeletal muscle is associated with loss of independence, falls risk, disability, institutionalization and death.

To determine whether a cocoa supplement enriched in flavonoids can improve plasma markers of oxidative stress and inflammation, physical performance and frailty in middle and older age subjects, we conducted a two-phase, randomized, double blind, clinical trial.