For Researchers

Association between Sarcopenia and Metabolic Syndrome in Middle-Aged and Older Non-Obese Adults: A Systematic Review and Meta-Analysis

H. Zhang, S. Lin, T. Gao, et al.

Nutrients. 2018 Mar 16;10(3). pii: E364. doi: 10.3390/nu10030364

Our study revealed that a higher proportion of metabolic syndrome (MetS) in middle-aged and older non-obese people with sarcopenia.

Moreover, sarcopenia was positively associated with MetS in this population. Further large-scale prospective cohort studies are needed to investigate the causality between sarcopenia and MetS.



SARC-F for Screening of Sarcopenia Among Older Adults: A Meta-analysis of Screening Test Accuracy

S. Ida, R. Kaneko, K. Murata

J Am Med Dir Assoc. 2018 May 16. pii: S1525-8610(18)30153-1. doi: 10.1016/j.jamda.2018.04.001. [Epub ahead of print]

Although the screening sensitivity performance of SARC-F was poor, its specificity was high; thus, it is an effective tool for selecting subjects who should undergo further testing for confirming a diagnosis of sarcopenia.



Sarcopenia: assessment of disease burden and strategies to improve outcomes

I. Liguori, G. Russo, L. Aran, et al.

Clin Interv Aging. 2018;13:913-927

Because sarcopenia is associated with important adverse health outcomes, such as frailty, hospitalization, and mortality, several therapeutic strategies have been identified that involve exercise training, nutritional supplementation, hormonal therapies, and novel strategies and are still under investigation.

At the present time, only physical exercise has showed a positive effect in managing and preventing sarcopenia and its adverse health outcomes. Thus, further well-designed and well-conducted studies on sarcopenia are needed.



Exercise interventions in healthy older adults with sarcopenia: A systematic review and meta-analysis

L. Vlietstra, W. Hendrickx, D.L. Waters

Australas J Ageing. 2018 Apr 11. doi: 10.1111/ajag.12521. [Epub ahead of print]

Exercise interventions significantly improved strength, balance and muscle mass. However, the number of trials was small and the training effect was inconsistent due to heterogeneity in exercise mode, duration and intensity. Lack of detailed description makes it impossible to reflect on the progressive resistance training approaches used. More research is needed to confirm these findings.



Frailty and multimorbidity: a systematic review and meta-analysis

D.L. Vetrano, K. Palmer, A. Marengoni, et al.

J Gerontol A Biol Sci Med Sci. 2018 May 3. doi: 10.1093/gerona/gly110. [Epub ahead of print]

Frailty and multimorbidity are two related conditions in older adults. Most frail individuals are also multimorbid but fewer multimorbid ones present also frailty.

Our findings are not conclusive regarding the causal association between the two conditions. Further longitudinal and well-designed studies may help to untangle the relationship between frailty and multimorbidity.



The Impact of Dietary Factors on Indices of Chronic Disease in Older People: A Systematic Review

C.A. Nowson, C. Service, J. Appleton, et al.

J Nutr Health Aging. 2018;22(2):282-296

The aims of this sudy were to i) conduct a systematic review of studies assessing dietary factors in relation to six key functional indicators which impact on quality of life in adults ≥65 yrs: non-fatal cardiovascular events, cognition, mental health, falls and fractures, physical health (muscle mass, strength) and frailty; and ii) assess if there was sufficient evidence to devise food-based dietary recommendations.