For Researchers

A free radical theory of frailty

J. Viña, C. Borras and M.C. Gomez-Cabrera

Free Radic Biol Med. 2018 Jun 26;124:358-363

In this review, we describe results from both, experimental animals and human cohorts, that lead us to the formulate this free radical theory of frailty.

The age-related loss of skeletal muscle mass and function: measurement and mechanisms of muscle fibre atrophy and muscle fibre loss in humans

D.J. Wilkinson, M. Piasecki and P.J. Atherton

Ageing Res Rev. 2018;47:123-132

This review will focus on muscle deterioration with ageing and highlight the two underpinning mechanisms regulating declines in muscle mass and function: muscle fibre atrophy and muscle fibre loss (hypoplasia) - and their measurement.

Cholecalciferol or 25-Hydroxycholecalciferol Supplementation Does Not Affect Muscle Strength and Physical Performance in Prefrail and Frail Older Adults

A.M.M. Vaes, M. Tieland, N. Toussaint, et al.

J Nutr. 2018;148(5):712-720

Vitamin D supplementation is proposed as a potential treatment strategy to counteract functional decline in older adults. However, data from randomized trials are either limited or inconsistent.

This study investigated the effect of daily supplementation with 25-hydroxycholecalciferol [25(OH)D3] or cholecalciferol (vitamin D3) on muscle strength and physical performance in older adults.

Validation of the sarcopenia index to assess muscle mass in the critically ill: A novel application of kidney function markers

E.F. Barreto, J.O. Poyant, H.H. Coville, et al.

Clin Nutr. 2018 Jun 8. pii: S0261-5614(18)30218-8. doi: 10.1016/j.clnu.2018.05.031. [Epub ahead of print]

Adverse outcomes for hospitalized patients with sarcopenia are well documented, and identification of patients at risk remains challenging. The sarcopenia index (SI), previously defined as (serum creatinine/serum cystatin C) × 100, could be an inexpensive, readily accessible, objective tool to predict muscle mass and risk for adverse clinical outcomes. The aim of this study was to assess the validity of the SI as a predictor of muscle mass

Time Spent in Sedentary Behaviour as Discriminant Criterion for Frailty in Older Adults

V.D. da Silva, S. Tribess, J. Meneguci, et al.

Int J Environ Res Public Health. 2018;15(7). pii: E1336

This paper aims to analyse whether time spent in sedentary behaviour was a discriminant criterion for frailty in older adults.

The frail older person does not exist: development of frailty profiles with latent class analysis

W.M. Looman, I.N. Fabbricotti, J.W. Blom, et al.

BMC Geriatr. 2018;18(1):84

The heterogeneous population of frail older people has differing needs and faces different health issues that should be considered to tailor care interventions.

Evaluation research of these interventions should acknowledge the heterogeneity of frailty by profiling.