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Muscle mass and strength gains following 6 months of resistance type exercise training are only partly preserved within one year with autonomous exercise continuation in older adults

T. Snijders, M. Leenders, L.C.P.G.M. de Groot, et al.

Exp Gerontol. 2019;121:71-78.

Although resistance type exercise training (RT) effectively increases muscle mass and strength in older individuals, it remains unclear whether gains in muscle mass and strength are maintained without continued supervised training. We assessed the capacity of older individuals to maintain muscle mass and strength gains one year after partaking in a successful RT program.

Dietary Patterns, Skeletal Muscle Health, and Sarcopenia in Older Adults

A. Granic, A.A. Sayer, S.M. Robinson

Nutrients. 2019 Mar 30;11(4). pii: E745. doi: 10.3390/nu11040745.

The prevalence of sarcopenia increases with age and leads to high personal, social, and economic costs. Finding adequate nutritional measures to maintain muscle health, preserve function, and independence for the growing population of older adults would have important scientific and societal implications.

The Impact of Physical Activity and Sedentary Behaviors on Frailty Levels

D.S. Kehler, O. Theou

Mech Ageing Dev. 2019 Mar 26. pii: S0047-6374(18)30244-6. doi: 10.1016/j.mad.2019.03.004. [Epub ahead of print]

Here, we summarize epidemiological and clinical trial evidence concerning the impact of physical activity and sedentary behaviors on frailty levels. We also analysed the National Health and Nutrition Examination Survey (NHANES) data to describe physical activity and sedentary behavior accumulation patterns across frailty levels and their impact on mortality risk.

Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence

K.J. Yoon, D. Zhang, S.J. Kim, et al.

Biochem Biophys Res Commun. 2019 Mar 22. pii: S0006-291X(19)30475-9. doi: 10.1016/j.bbrc.2019.03.086. [Epub ahead of print]

Here we show that pre-activation of AMPK with the AMPK activator, AICAR can mitigate the diminished cellular viability of skeletal muscle cells induced by doxorubicin, which accelerates senescence through free radical production.

A comparison between an ICT tool and a traditional physical measure for frailty evaluation in older adults

A. Mulasso, P.R. Brustio, A. Rainoldi, et al.

BMC Geriatr. 2019;19(1):88.

This study aimed to: i) evaluate differences in the mobility index (MI) provided by ADAMO system, an innovative remote monitoring device for older adults; ii) compare the association of the MI and a traditional physical measure with frailty.

Establishing the Link Between Lean Mass and Grip Strength Cut-points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference

P.M. Cawthon, T.G. Travison, T.M. Manini, et al.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14. pii: glz081. doi: 10.1093/gerona/glz081. [Epub ahead of print]

Lack of consensus on how to diagnose sarcopenia has limited the ability to diagnose this condition and hindered drug development. The Sarcopenia Definitions and Outcomes Consortium (SDOC) was formed to develop evidence-based diagnostic cut-points for lean mass and/or muscle strength that identify people at increased risk of mobility disability. We describe here the proceedings of a meeting of SDOC and other experts to discuss strategic considerations in the development of evidence-based sarcopenia definition.