For Researchers

ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty

L. Rodriguez-Mañas, I. Araujo de Carvalho, S. Bhasin,et al.

J Frailty Aging. 2020;9(1):4-8. doi: 10.14283/jfa.2019.32.

The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - a group of academic and industry scientists from around the world -- met in February 2019 to discuss the current state of biomarker development for frailty and sarcopenia.

Sarcoscore: A Novel Approach for Assessing Sarcopenia and Functional Disability in Older Adults

Y. Osuka, H. Kim, H. Kawai,et al.

J Clin Med. 2020;9(3). pii: E692. doi: 10.3390/jcm9030692.

We developed an index for assessing sarcopenia degree (sarcoscore) and compared it to the Asian Working Group for Sarcopenia (AWGS) criteria.

Circulating Interleukin-6 Is Associated with Skeletal Muscle Strength, Quality, and Functional Adaptation with Exercise Training in Mobility-Limited Older Adults

G.J Grosicki, B.B. Barrett, D.A. Englund,et al.

J Frailty Aging. 2020;9(1):57-63. doi: 10.14283/jfa.2019.30.

The aim was to investigate relationships between circulating IL-6, skeletal muscle health and exercise adaptation in mobility-limited older adults.

Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium

S. Bhasin, T.G. Travison, T.M. Maniniz, et al.

J Am Geriatr Soc. 2020 Mar 9. doi: 10.1111/jgs.16372. [Epub ahead of print]

The aim was to develop an evidence-based definition of sarcopenia that can facilitate identification of older adults at risk for clinically relevant outcomes (eg, self-reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition and Outcomes Consortium (SDOC) crafted a set of position statements informed by a literature review and SDOC's analyses of eight epidemiologic studies, six randomized clinical trials, four cohort studies of special populations, and two nationally representative population-based studies.

The Tilburg Frailty Indicator (TFI): New Evidence for Its Validity

R.J. Gobbens, P. Boersma, I. Uchmanowicz, et al.

Clin Interv Aging. 2020;15:265-274

The Tilburg Frailty Indicator (TFI) is a self-report user-friendly questionnaire for assessing multidimensional frailty among community-dwelling older people. The main aim of this study is to re-evaluate the validity of the TFI, both cross-sectionally and longitudinally, focusing on the predictive value of the total TFI and its physical, psychological, and social domains for adverse outcomes disability, indicators of healthcare utilization, and falls.

Protein-Related Dietary Parameters and Frailty Status in Older Community-Dwellers across Different Frailty Instruments

H.J. Coelho-Júnior, R. Calvani, A. Picca, et al.

Nutrients. 2020;12(2). pii: E508. doi: 10.3390/nu12020508.

The present study investigated the associations between frailty status and (a) daily protein intake, (b) daily body weight-adjusted protein intake, (c) branched-chain amino acid (BCAA) consumption, (d) evenness of protein distribution across main meals, (e) number of daily meals providing at least 30 g of protein, and (f) number of daily meals providing at least 0.4 g protein/kg of body weight in community-dwelling older adults. The relationship between frailty status and protein-related dietary parameters was explored across different frailty assessment tools.

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