For Researchers

Validation of the sarcopenia index to assess muscle mass in the critically ill: A novel application of kidney function markers

E.F. Barreto, J.O. Poyant, H.H. Coville, et al.

Clin Nutr. 2018 Jun 8. pii: S0261-5614(18)30218-8. doi: 10.1016/j.clnu.2018.05.031. [Epub ahead of print]

Adverse outcomes for hospitalized patients with sarcopenia are well documented, and identification of patients at risk remains challenging. The sarcopenia index (SI), previously defined as (serum creatinine/serum cystatin C) × 100, could be an inexpensive, readily accessible, objective tool to predict muscle mass and risk for adverse clinical outcomes. The aim of this study was to assess the validity of the SI as a predictor of muscle mass

Time Spent in Sedentary Behaviour as Discriminant Criterion for Frailty in Older Adults

V.D. da Silva, S. Tribess, J. Meneguci, et al.

Int J Environ Res Public Health. 2018;15(7). pii: E1336

This paper aims to analyse whether time spent in sedentary behaviour was a discriminant criterion for frailty in older adults.

The frail older person does not exist: development of frailty profiles with latent class analysis

W.M. Looman, I.N. Fabbricotti, J.W. Blom, et al.

BMC Geriatr. 2018;18(1):84

The heterogeneous population of frail older people has differing needs and faces different health issues that should be considered to tailor care interventions.

Evaluation research of these interventions should acknowledge the heterogeneity of frailty by profiling.  

Association between Sarcopenia and Metabolic Syndrome in Middle-Aged and Older Non-Obese Adults: A Systematic Review and Meta-Analysis

H. Zhang, S. Lin, T. Gao, et al.

Nutrients. 2018 Mar 16;10(3). pii: E364. doi: 10.3390/nu10030364

Our study revealed that a higher proportion of metabolic syndrome (MetS) in middle-aged and older non-obese people with sarcopenia.

Moreover, sarcopenia was positively associated with MetS in this population. Further large-scale prospective cohort studies are needed to investigate the causality between sarcopenia and MetS.



SARC-F for Screening of Sarcopenia Among Older Adults: A Meta-analysis of Screening Test Accuracy

S. Ida, R. Kaneko, K. Murata

J Am Med Dir Assoc. 2018 May 16. pii: S1525-8610(18)30153-1. doi: 10.1016/j.jamda.2018.04.001. [Epub ahead of print]

Although the screening sensitivity performance of SARC-F was poor, its specificity was high; thus, it is an effective tool for selecting subjects who should undergo further testing for confirming a diagnosis of sarcopenia.



Sarcopenia: assessment of disease burden and strategies to improve outcomes

I. Liguori, G. Russo, L. Aran, et al.

Clin Interv Aging. 2018;13:913-927

Because sarcopenia is associated with important adverse health outcomes, such as frailty, hospitalization, and mortality, several therapeutic strategies have been identified that involve exercise training, nutritional supplementation, hormonal therapies, and novel strategies and are still under investigation.

At the present time, only physical exercise has showed a positive effect in managing and preventing sarcopenia and its adverse health outcomes. Thus, further well-designed and well-conducted studies on sarcopenia are needed.