For Researchers

Establishing the Link Between Lean Mass and Grip Strength Cut-points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference

P.M. Cawthon, T.G. Travison, T.M. Manini, et al.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14. pii: glz081. doi: 10.1093/gerona/glz081. [Epub ahead of print]

Lack of consensus on how to diagnose sarcopenia has limited the ability to diagnose this condition and hindered drug development. The Sarcopenia Definitions and Outcomes Consortium (SDOC) was formed to develop evidence-based diagnostic cut-points for lean mass and/or muscle strength that identify people at increased risk of mobility disability. We describe here the proceedings of a meeting of SDOC and other experts to discuss strategic considerations in the development of evidence-based sarcopenia definition.

Nutritional interventions to prevent and treat frailty

A.J. Cruz-Jentoft, J. Woo

Curr Opin Clin Nutr Metab Care. 2019 Feb 18. doi: 10.1097/MCO.0000000000000556. [Epub ahead of print]

Frailty is a multidimensional condition common in older adults, where reduced resiliency leads to adverse outcomes. It has strong links with malnutrition and sarcopenia, mostly through muscle health. This review explores the links between nutrition and frailty from different perspectives.

Can Physical Activity Offset the Detrimental Consequences of Sedentary Time on Frailty? A Moderation Analysis in 749 Older Adults Measured With Accelerometers

A. Mañas, B.D. Pozo-Cruz, I. Rodríguez-Gómez, et al.

J Am Med Dir Assoc. 2019 Feb 6. pii: S1525-8610(18)30719-9. doi: 10.1016/j.jamda.2018.12.012. [Epub ahead of print]

The Johnson-Neyman technique determined that the estimated moderate-to-vigorous physical activity point was 27.25 minutes/d, from which sedentary time has no significant effect on frailty.

Exercise training increases skeletal muscle strength independent of hypertrophy in older adults aged 75 years and older

H. Lee, I.G. Kim, C. Sung, et al.

Geriatr Gerontol Int. 2019;19(3):265-270

We investigated whether exercise-mediated acquisition of muscle mass and strength would occur in a concurrent manner in older adults.

A total of 152 community-dwelling older adults (young-old aged 65-74 years, old-old aged >75 years) were allocated into either 8-week comprehensive exercise training or the control group.

The role of omega-3 in the prevention and treatment of sarcopenia

J. Dupont, L. Dedeyne, S. Dalle, et al.

Aging Clin Exp Res. 2019 Feb 19. doi: 10.1007/s40520-019-01146-1. [Epub ahead of print]

This narrative review provides an overview of the current knowledge about omega-3 PUFAs and their role in the prevention and treatment of sarcopenia. We conclude that there is growing evidence for a beneficial effect of omega-3 PUFAs supplementation in sarcopenic older persons, which may add to the effect of exercise and/or protein supplementation.

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

H. Neelakantan, C.R. Brightwell, T.G. Graber, et al.

Biochem Pharmacol. 2019 Feb 9. pii: S0006-2952(19)30046-2. doi: 10.1016/j.bcp.2019.02.008. [Epub ahead of print]

We recently developed small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed with aging in skeletal muscles and linked to impairment of the NAD+ salvage pathway, dysregulated sirtuin 1 activity, and increased muSC senescence. We hypothesized that NNMT inhibitor (NNMTi) treatment will rescue age-related deficits in muSC activity to promote superior regeneration post-injury in aging muscle.