For Researchers

Identification of frailty by the use of the SEGAm scale (part A) in geriatrical consultation

A.A. Zulfiqar

Geriatr Psychol Neuropsychiatr Vieil. 2018;16(3):269-277

A prospective, observational study was performed in subjects aged over 75 years, coming from the first neuro-geriatric consultation, from July 3, 2017 to August 18, 2017, included in the CHU Rouen, and benefiting from frailty screening through the use of the grid SEGAm (part A); this correlated with the subjective opinion of the nurse.

Comparing Mini Sarcopenia Risk Assessment With SARC-F for Screening Sarcopenia in Community-Dwelling Older Adults

M. Yang, X. Hu, L. Xie, et al.

J Am Med Dir Assoc. 2018 Jun 13. pii: S1525-8610(18)30229-9. doi: 10.1016/j.jamda.2018.04.012. [Epub ahead of print]

The Mini Sarcopenia Risk Assessment (MSRA), a new sarcopenia screening tool, has 2 versions: MSRA-7 (full version, 7 items) and MSRA-5 (short version, 5 items).

We aimed to compare the diagnostic values of MSRA-7 and MSRA-5 to SARC-F for screening sarcopenia.

SARC-F for sarcopenia screening in community-dwelling older adults: Are 3 items enough?

M. Yang, X. Hu, L. Xie, et al.

Medicine (Baltimore). 2018;97(30):e11726

A 3-item SARC-F (termed SARC-F-3 in our study) was recently suggested as a screening tool for sarcopenia.

The aim of this study was to compare the diagnostic value of SARC-F-3 to SARC-F in community-dwelling older people.

A free radical theory of frailty

J. Viña, C. Borras and M.C. Gomez-Cabrera

Free Radic Biol Med. 2018 Jun 26;124:358-363

In this review, we describe results from both, experimental animals and human cohorts, that lead us to the formulate this free radical theory of frailty.

The age-related loss of skeletal muscle mass and function: measurement and mechanisms of muscle fibre atrophy and muscle fibre loss in humans

D.J. Wilkinson, M. Piasecki and P.J. Atherton

Ageing Res Rev. 2018;47:123-132

This review will focus on muscle deterioration with ageing and highlight the two underpinning mechanisms regulating declines in muscle mass and function: muscle fibre atrophy and muscle fibre loss (hypoplasia) - and their measurement.

Cholecalciferol or 25-Hydroxycholecalciferol Supplementation Does Not Affect Muscle Strength and Physical Performance in Prefrail and Frail Older Adults

A.M.M. Vaes, M. Tieland, N. Toussaint, et al.

J Nutr. 2018;148(5):712-720

Vitamin D supplementation is proposed as a potential treatment strategy to counteract functional decline in older adults. However, data from randomized trials are either limited or inconsistent.

This study investigated the effect of daily supplementation with 25-hydroxycholecalciferol [25(OH)D3] or cholecalciferol (vitamin D3) on muscle strength and physical performance in older adults.