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Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial

M. Cesari, F. Landi, R. Calvani, et al.

Aging Clin Exp Res Epub 2017 Feb 10


In the present article, the rationale that guided the operationalization of the theoretical concept of physical frailty and sarcopenia (PF&S), the condition of interest for the “Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies” (SPRINTT) trial, is presented.

Frailty as a Predictor of Acute Kidney Injury in Hospitalized Elderly Patients: A Single Center, Retrospective Cohort Study

S.H. Baek, S.W. Lee, S.W. Kim, et al.

PLoS One. 2016;11(6):e0156444

This study aimed at determining the effect of frailty as a predictor of acute kidney injury (AKI). 533 hospitalized elderly patients (aged ≥ 65 years) were retrospectively enrolled.

Data obtained suggest that frailty may independently predict the development of AKI and adverse outcomes in geriatric inpatients.

Prevalence and Incidence of Frailty in Community-Dwelling Older People: Beijing Longitudinal Study of Aging II

Z. Zheng, S. Guan, H. Ding, et al.

J Am Geriatr Soc. 2016;64(6):1281-6

The objective of this secondary analysis of a prospective cohort study was to estimate the prevalence and incidence of frailty and evaluate the effect of frailty on adverse outcomes in 10,039 Chinese elderly adults (≥55 years). A 12.3% prevalence and a 13% incidence of frailty was demonstrated in community-dwelling Chinese older adults.

Prevalence of Frailty and Factors Associated with Frailty in Individuals Aged 90 and Older: The 90+ Study

D.R. Lee, C.H. Kawas, L. Gibbs, et al.

J Am Geriatr Soc. 2016;64(11):2257-2262

This study estimated the overall prevalence of frailty in people aged 90 and older to be 28.0%. The overall prevalence of frailty was 24% in those aged 90 to 94 and 39.5% in those aged 95 and older. The prevalence of frailty was significantly associated with age in women but not men and with living with relatives or caregiver or in a group setting.

Frailty as a major factor in the increate risk of death and disability in older people with diabetes

M. Castro-Rodríguez, J.A. Carnicero, F. J. Garcia-Garcia, et al.

J Am Med Dir Assoc. 2016;17(10):949-55

The objective of this prospective cohort study on 1825 individuals (≥65years old) was to assess the role of frailty in predicting death and incident disability in older adults with type 2 diabetes mellitus. The results obtained suggest that frailty is an important risk factor for death and disability in older adults with diabetes, supporting the recent recommendations that frailty status should be routinely assessed in these patients.

Frailty Is Associated with an Increased Risk of Incident Type 2 Diabetes in the Elderly

N. Veronese, B. Stubbs, L. Fontana, et al.

J Am Med Dir Assoc. 2016;17(10):902-7

This longitudinal study (follow-up of 4.4 years) aimed to investigate whether frailty is associated with an increased risk of incident type 2 diabetes mellitus (T2DM) in a prospective cohort of community-dwelling older people. Among community-dwelling older people, frailty and prefrailty were significant and independent predictors of T2DM, which is a major and potentially preventable risk factor for multiple comorbidities.