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Associations between dietary patterns at age 71 and the prevalence of sarcopenia 16 years later

M. Karlsson, W. Becker, K. Michaëlsson, et al.

Clin Nutr. 2019 Apr 18. pii: S0261-5614(19)30182-7. doi: 10.1016/j.clnu.2019.04.009. [Epub ahead of print]

The growing recognition of the significance of sarcopenia has highlighted the need to understand etiologic factors, where food intake likely plays a role. The aim was to investigate the association between dietary patterns at mean age 71 and the prevalence of sarcopenia at mean age 87 in a Swedish cohort of community dwelling men.

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study

K. Liberman, R. Njemini, Y. Luiking, et al.

Aging Clin Exp Res. 2019 May 2. doi: 10.1007/s40520-019-01208-4. [Epub ahead of print]

A chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited. The aim was to investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis.

Sex-specific differences in the association of vitamin D with low lean mass and frailty: Results from the Berlin Aging Study II

D. Spira, N. Buchmann, M. König, et al.

Nutrition. 2019;62:1-6

Sex-specific differences in factors associated with aging and lifespan, such as sarcopenia and disease development, are increasingly recognized. The study aims to assess sex-specific aspects of the association between vitamin D insufficiency and low lean mass as well as between vitamin D insufficiency and the frailty phenotype.

Phase angle and metabolic equivalents as predictors of frailty transitions in advanced age

B.M. Zanforlini, C. Trevisan, A. Bertocco, et al.

Exp Gerontol. 2019 Apr 24. pii: S0531-5565(19)30121-4. doi: 10.1016/j.exger.2019.04.016. [Epub ahead of print]

The aim of this prospective study was to investigate whether two cellular and metabolic health indices, phase angle (PhA) and metabolic equivalents (METs), can predict changes in frailty states in fit community-dwelling older people.

Ultrasound measurement of rectus femoris muscle thickness as a quick screening test for sarcopenia assessment

K. Rustani, L. Kundisova, P.L. Capecchi, et al.

Arch Gerontol Geriatr. 2019;83:151-154

According to European Working Group on Sarcopenia in Older People (EWGSOP) the diagnosis of sarcopenia requires the assessment of muscle mass, muscle force and function, that is time-consuming and not easily at hand in everyday clinical practice. We propose the B-mode ultrasound measurement of muscle thickness as a quick screening test to assess the presence of sarcopenia.

Effects of IGF-1 isoforms on muscle growth and sarcopenia

F. Ascenzi, L. Barberi, G. Dobrowolny, et al.

Aging Cell. 2019 Apr 5:e12954. doi: 10.1111/acel.12954. [Epub ahead of print]

The insulin-like growth factor-1 (IGF-1) has been implicated in many anabolic pathways in skeletal muscle. IGF-1 exists in different isoforms that might exert different role in skeletal muscle. Here we study the effects of two full propeptides IGF-1Ea and IGF-1Eb in skeletal muscle, with the aim to define whether and through which mechanisms their overexpression impacts muscle aging.