For Researchers

Reported Weight Change in Older Adults and Presence of Frailty

R.S. Crow, C.L. Petersen, S.B. Cook, et al.

J Frailty Aging. 2020;9(2):74-81. doi: 10.14283/jfa.2019.44.

A 5% change in weight is a significant predictor for frailty and obesity. We ascertained how self-reported weight change over the lifespan impacts rates of frailty in older adults.

Physical activity and exercise: Strategies to manage frailty

J. Angulo, M. El Assar, A. Álvarez-Bustos, et al.

Redox Biol. 2020 Mar 20:101513. doi: 10.1016/j.redox.2020.101513. [Epub ahead of print]

Frailty, a consequence of the interaction of the aging process and certain chronic diseases, compromises functional outcomes in the elderly and substantially increases their risk for developing disabilities and other adverse outcomes. Frailty follows from the combination of several impaired physiological mechanisms affecting multiple organs and systems. And, though frailty and sarcopenia are related, they are two different conditions. Thus, strategies to preserve or improve functional status should consider systemic function in addition to muscle conditioning. Physical activity/exercise is considered one of the main strategies to counteract frailty-related physical impairment in the elderly.

Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial

F.M. Martínez-Arnau, R. Fonfría-Vivas, C. Buigues, et al.

Nutrients. 2020 Mar 27;12(4). pii: E932. doi: 10.3390/nu12040932.

We assessed the efficacy of leucine administration to evaluate whether the regular intake of this essential amino acid can improve muscle mass, muscle strength and functional performance and respiratory muscle function in institutionalized older individuals.

Circulating MicroRNAs in Plasma Decrease in Response to Sarcopenia in the Elderly

N. He, Y.L. Zhang, Y. Zhang, et al.

Front Genet. 2020 Mar 5;11:167. doi: 10.3389/fgene.2020.00167. eCollection 2020.

Sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is a major cause of morbidity and mortality in elders. Current diagnostic criteria of sarcopenia have not been agreed internationally, and the clinical diagnostic biomarkers for sarcopenia have not been identified. Circulating miRNAs (miRNAs, miRs) have recently been characterized as novel biomarkers for sarcopenia. However, the change of circulating miRNAs in response to sarcopenia are still not fully understood.

Factors associated with sarcopenia: A cross-sectional analysis using UK Biobank

F. Petermann-Rocha, M. Chen, S.R. Gray, et al.

Maturitas. 2020 Mar;133:60-67. doi: 10.1016/j.maturitas.2020.01.004. Epub 2020 Jan 8.

The critical sociodemographic, lifestyle and diseases factors influencing sarcopenia, defined by the current European Working Group on Sarcopenia 2 (EWGSOP2) classification and cut-off points, have not yet been fully elucidated. This study aimed, therefore, to determine sociodemographic, anthropometric, lifestyle and health-related factors associated with sarcopenia using the new EWGSOP2 definition.

Differences in the Prevalence of Sarcopenia in Community-Dwelling, Nursing Home and Hospitalized Individuals. A Systematic Review and Meta-Analysis

S.K. Papadopoulou, P. Tsintavis, P. Potsaki, et al.

J Nutr Health Aging. 2020;24(1):83-90. doi: 10.1007/s12603-019-1267-x.

The current systematic review and meta-analysis study was carried out to estimate the overall prevalence of sarcopenia in both males and females in different regions around the world and to show the major differences in its occurrence among different populations.

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