For Researchers

Physical Frailty Assessment in Older Women: Can Simplification Be Achieved Without Loss of Syndrome Measurement Validity?

Q.L. Xue, J. Tian, L.P. Fried, et al.

Am J Epidemiol. 2016;183(11):1037-44

Different phenotypes have increasingly been used as tools for clinical characterization of frailty among older adults. Although there have been studies about the comparability and effectiveness of various simplifications and approximations of existing frailty phenotypes for risk prediction, there have been no studies in which investigators evaluated the stability of the clinical characterization achieved. Findings obtained shown that it was no merely the number of criteria used to characterize the PFPs but rather the specific criteria combinations that predicted the risk of adverse outcomes. There are clinically important contexts in which simplified PFPs cannot be used interchangeably.

A Multicomponent Exercise Intervention that Reverses Frailty and Improves Cognition, Emotion, and Social Networking in the Community-Dwelling Frail Elderly: A Randomized Clinical Trial

F.J. Tarazona-Santabalbina, M.C. Gómez-Cabrera, P. Pérez-Ros, et al.

J Am Med Dir Assoc. 2016;17(5):426-33

The aim of this study is to ascertain if a supervised-facility multicomponent exercise program (MEP) when performed by frail older persons can reverse frailty and improve functionality; cognitive, emotional, and social networking; as well as biological biomarkers of frailty, when compared with a controlled population that received no training. 

Motor Performance and Physical Activity as Predictors of Prospective Falls in Community-Dwelling Older Adults by Frailty Level: Application of Wearable Technology

M.J. Mohler, C.S. Wendel , R.E. Taylor-Piliae, et al.

Gerontology. 2016;62(6):654-664

This study aimed to evaluate wearable sensor-based measures of gait, balance, and physical activity that are predictive of future falls in community-dwelling older adults. Results obtained suggests that independent predictors of falls are dependent on frailty status. Among sensor-derived parameters, balance deficit, longer typical walking episodes, and shorter typical standing episodes were the most sensitive predictors of prospective falls in the combined pre-frail and frail sample. Gait deficit was not a sensitive fall predictor in the context of frailty status.

Neuromuscular function in different stages of sarcopenia

T. Morat, K.J. Gilmore and C.L. Rice

Exp Gerontol. 2016;81:28-36

This study applied the screening tool developed by the European Working Group on Sarcopenia in Older People (EWGSOP) on seniors aged over 65years and concurrently tested various laboratory-based indices of neuromuscular function. Based on gait speed, handgrip strength and muscle mass all subjects were categorized into one of the three conceptual sarcopenia stages (pre-sarcopenia, sarcopenia, severe sarcopenia). The laboratory tests found neuromuscular differences among the 3 groups which generally supported the classification scheme and helped to illustrate some key factors that could explain differences in functional capacities.

High Levels of Heavy Metals Increase the Prevalence of Sarcopenia in the Elderly Population

J.I. Yoo, Y.C. Ha, Y.K. Lee, et al.

J Bone Metab. 2016;23(2):101-9

Despite increasing concern regarding health problems as a result of environmental pollutants, no association of toxic heavy metals with sarcopenia has been demonstrated in the general population. In this article the association of heavy metals, including lead, mercury and cadmium, with sarcopenia in the Korean population was investigated. This study demonstrates that high levels of blood lead, mercury and cadmium increase the prevalence of sarcopenia in both genders of elderly populations.

Macronutrients Intake and Incident Frailty in Older Adults: A Prospective Cohort Study

H. Sandoval-Insausti, R.F. Pérez-Tasigchana, E. López-García, et al.

J Gerontol A Biol Sci Med Sci 2016;71(10):1329-34

This study examined the association of protein and other macronutrient intake with the risk of frailty in older adults. Authors concluded that the intake of total protein, animal protein, and MUFAs was inversely associated with incident frailty. Promoting the intake of these nutrients might reduce frailty.