For Researchers

The “Sarcopenia and Physical fRailty IN older people: multicomponenT Treatment strategies” (SPRINTT) project: advancing the care of physically frail and sarcopenic older people

R. Bernabei, L. Mariotti, P. Bordes, et al.

Aging Clin Exp Res Epub 2017 Feb 10

CLICK HERE TO READ THE FULL TEXT

The absolute and relative number of people aged 65+ is on a sharp rise worldwide. Such a demographic transition is certainly a desirable result of the magnificent combination of socioeconomic development, technological, and medical advancements, and the establishment of solid public health systems.

Biomarkers for physical frailty and sarcopenia

R. Calvani, F. Marini, M. Cesari, et al.

Aging Clin Exp Res Epub 2017 Feb 10

CLICK HERE TO READ THE FULL TEXT

This review provides an overview of currently available biological markers for PF and sarcopenia, as well as a critical appraisal of strengths and weaknesses of traditional procedures for biomarker development in the field. A novel approach for biomarker identification and validation, based on multivariate methodologies, is also discussed.

 

Nutrition, frailty, and sarcopenia

A. J. Cruz-Jentoft, E. Kiesswetter, M. Drey, et al.

Aging Clin Exp Res Epub 2017 Feb 10

CLICK HERE TO READ THE FULL TEXT

This brief review explores the role of energy and protein intake and other key nutrients on muscle function.

Physical frailty and sarcopenia (PF&S): a point of view from the industry

S. Del Signore and R.Roubenff

Aging Clin Exp Res Epub 2017 Feb 10

CLICK HERE TO READ THE FULL TEXT

We agree with regulators that better characterization of subpopulations, not only in elderly patients, can improve the benefit risk ratio of medicines. At the same time, we believe it is in the public health interest to develop novel drugs indicated for specific geriatric conditions.

Possibilities of ICT-supported services in the clinical management of older adults

M. Vollenbroek-Hutten, S. Jansen-Kosterink, M. Tabak, et al.

Aging Clin Exp Res Epub 2017 Feb 10

CLICK HERE TO READ THE FULL TEXT

Aim of this article is to describe the possible field of application for ICTsupported services in the management of older adults, in particular those with functional impairment.

The need of operational paradigms for frailty in older persons: the SPRINTT project

M. Cesari, E. Marzetti, R. Calvani, et al.

Aging Clin Exp Res Epub 2017 Feb 10

CLICK HERE TO READ THE FULL TEXT

The lack of consensus around a single operational definition has limited the clinical implementation of frailty in clinical practice.

In this context, the recently funded “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) project (largely based on such a novel approach) may indeed fill an important gap in the field and provide key insights for counteracting the disabling cascade in the elderly.

Pages