For Researchers

Sex-specific differences in the association of vitamin D with low lean mass and frailty: Results from the Berlin Aging Study II

D. Spira, N. Buchmann, M. König, et al.

Nutrition. 2019;62:1-6

Sex-specific differences in factors associated with aging and lifespan, such as sarcopenia and disease development, are increasingly recognized. The study aims to assess sex-specific aspects of the association between vitamin D insufficiency and low lean mass as well as between vitamin D insufficiency and the frailty phenotype.

Phase angle and metabolic equivalents as predictors of frailty transitions in advanced age

B.M. Zanforlini, C. Trevisan, A. Bertocco, et al.

Exp Gerontol. 2019 Apr 24. pii: S0531-5565(19)30121-4. doi: 10.1016/j.exger.2019.04.016. [Epub ahead of print]

The aim of this prospective study was to investigate whether two cellular and metabolic health indices, phase angle (PhA) and metabolic equivalents (METs), can predict changes in frailty states in fit community-dwelling older people.

Ultrasound measurement of rectus femoris muscle thickness as a quick screening test for sarcopenia assessment

K. Rustani, L. Kundisova, P.L. Capecchi, et al.

Arch Gerontol Geriatr. 2019;83:151-154

According to European Working Group on Sarcopenia in Older People (EWGSOP) the diagnosis of sarcopenia requires the assessment of muscle mass, muscle force and function, that is time-consuming and not easily at hand in everyday clinical practice. We propose the B-mode ultrasound measurement of muscle thickness as a quick screening test to assess the presence of sarcopenia.

Effects of IGF-1 isoforms on muscle growth and sarcopenia

F. Ascenzi, L. Barberi, G. Dobrowolny, et al.

Aging Cell. 2019 Apr 5:e12954. doi: 10.1111/acel.12954. [Epub ahead of print]

The insulin-like growth factor-1 (IGF-1) has been implicated in many anabolic pathways in skeletal muscle. IGF-1 exists in different isoforms that might exert different role in skeletal muscle. Here we study the effects of two full propeptides IGF-1Ea and IGF-1Eb in skeletal muscle, with the aim to define whether and through which mechanisms their overexpression impacts muscle aging.

Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention

C.W. Li, K. Yu, N. Shyh-Chang, et al.

J Cachexia Sarcopenia Muscle. 2019 Apr 10. doi: 10.1002/jcsm.12417. [Epub ahead of print]

In this study, we evaluated whether proinflammatory cytokines are associated with the onset of sarcopenia, which circulating factors are associated with the severity of sarcopenia, and how these factors change after lifestyle interventions in sarcopenic elderly persons.

Muscle mass and strength gains following 6 months of resistance type exercise training are only partly preserved within one year with autonomous exercise continuation in older adults

T. Snijders, M. Leenders, L.C.P.G.M. de Groot, et al.

Exp Gerontol. 2019;121:71-78.

Although resistance type exercise training (RT) effectively increases muscle mass and strength in older individuals, it remains unclear whether gains in muscle mass and strength are maintained without continued supervised training. We assessed the capacity of older individuals to maintain muscle mass and strength gains one year after partaking in a successful RT program.