For Researchers

Smoking and Diabetes as Predictive Factors of Accelerated Loss of Muscle Mass in Middle-Aged and Older Women: A Six-Year Retrospective Cohort Study

N. Lee, C.J. Choi

J Womens Health (Larchmt). 2019 May 23. doi: 10.1089/jwh.2018.7527. [Epub ahead of print]

Preservation of muscle mass during aging reduces the risk of frailty and age-related chronic diseases. We investigated the lifestyle, psychological factors, and common cardiometabolic diseases associated with accelerated muscle loss in middle-aged and older women.

Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project

B. Hsu, V. Hirani, R.G. Cumming, et al.

J Gerontol A Biol Sci Med Sci. 2019;74(6):835-841

Previous studies demonstrated associations between interleukin-6 (IL-6) and frailty, but associations between a wide range of cytokines, chemokines, and growth factors with prevalent and incident frailty has not been studied.

Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty "cytokinome" at its core

E. Marzetti, A. Picca, F. Marini, et al.

Exp Gerontol. 2019;122:129-138

This study was designed to explore the association between a large panel of inflammatory biomolecules and physical frailty and sarcopenia in older adults through a multivariate statistical approach. Gender-specific inflammatory patterns were also explored.

High flavonoid cocoa supplement ameliorates plasma oxidative stress and inflammation levels while improving mobility and quality of life in older subjects: a double blind randomized clinical trial

L. Munguia, I. Rubio-Gayosso, I. Ramirez-Sanchez, et al.

J Gerontol A Biol Sci Med Sci. 2019 May 6. pii: glz107. doi: 10.1093/gerona/glz107. [Epub ahead of print]

The age-related decline in mass, strength and performance of skeletal muscle is associated with loss of independence, falls risk, disability, institutionalization and death.

To determine whether a cocoa supplement enriched in flavonoids can improve plasma markers of oxidative stress and inflammation, physical performance and frailty in middle and older age subjects, we conducted a two-phase, randomized, double blind, clinical trial.

Effects of dietary patterns and low protein intake on sarcopenia risk in the very old: The Newcastle 85+ study

A. Granic, N. Mendonça, A.A. Sayer, et al.

Clin Nutr. 2019 Jan 21. pii: S0261-5614(19)30011-1. doi: 10.1016/j.clnu.2019.01.009. [Epub ahead of print]

The aim was to investigate the association between healthy dietary patterns DPs and the risk of sarcopenia over 3 years, and to determine whether protein intake influences this relationship in community-dwelling older adults from the Newcastle 85 + Study.

Higher protein intake is associated with a lower likelihood of frailty among older women, Kuopio OSTPRE-Fracture Prevention Study

M. Isanejad, J. Sirola, T. Rikkonen, et al.

Eur J Nutr. 2019 May 7. doi: 10.1007/s00394-019-01978-7. [Epub ahead of print]

Nordic nutrition recommendations (2012) suggest protein intake ≥ 1.1 g/kg body weight (BW) to preserve physical function in Nordic older adults. However, no published study has used this cut-off to evaluate the association between protein intake and frailty. This study examined associations between protein intake, and sources of protein intake, with frailty status at the 3-year follow-up.

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