For Researchers

Dysregulated homeostatic pathways in sarcopenia among frail older adults

T.P. Ng, Y. Lu, R.W.M. Choo, et al.

Aging Cell. 2018 Oct 9:e12842. doi: 10.1111/acel.12842. [Epub ahead of print]

Sarcopenia, a core feature of the physical frailty syndrome, is characterized by multisystem physiological dysregulation. No study has explored qualitatively the hierarchical network of relationships among different dysregulated pathways involved in the pathogenesis of sarcopenia.

Low vitamin intake is associated with risk of frailty in older adults

T. Balboa-Castillo, E.A. Struijk, E. Lopez-Garcia, et al.

Age Ageing. 2018;47(6):872-879

The association between vitamin intake and frailty has hardly been studied. The objective was to assess the association of dietary vitamin intake with incident frailty in older adults from Spain.

Evaluation of appendicular lean mass using bio impedance in persons aged 80+: A new equation based on the BUTTERFLY-study

S. Vermeiren, D. Beckwée, R. Vella-Azzopardi, et al.

Clin Nutr. 2018 Aug 2. pii: S0261-5614(18)31240-8. doi: 10.1016/j.clnu.2018.07.029. [Epub ahead of print]

To date, the accuracy of bio-impedance (BIA) to assess body composition & sarcopenia in persons aged 80 and over remains unclear.

We aimed to evaluate the agreement between dual energy X-ray absorptiometry (DXA) and BIA equations to determine lean mass, as well as their suitability to identify sarcopenia.

Handgrip Strength, Function, and Mortality in Older Adults: A Time-varying Approach

R.P. McGrath, B.M. Vincent, I.M. Lee, et al.

Med Sci Sports Exerc. 2018;50(11):2259-2266

The aim of this study is to determine the time-varying associations between 1) decreased handgrip strength and disabilities in each activity of daily living (ADL) function, and 2) disaggregated ADL limitations and time to mortality in older adults.

Sarcopenia: revised European consensus on definition and diagnosis

A.J. Cruz-Jentoft, G. Bahat, J. Bauer, Y. Boirie, et al.

Age Ageing. 2018 Oct 12. doi: 10.1093/ageing/afy169. [Epub ahead of print]

In 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings.

The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants

E. Marzetti, M. Cesari, R. Calvani, et al.

Exp Gerontol. 2018;113:48-57


Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees.