For Researchers

Urinary 8-oxo-7,8-dihydroguanosine as a potential biomarker of frailty for elderly patients with cardiovascular disease

Y.D. Liang, Q. Liu, M.H. Du, et al.

Free Radic Biol Med. 2020 Mar 23;152:248-254. doi: 10.1016/j.freeradbiomed.2020.03.011. [Epub ahead of print]

The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) in urine are two aging biomarkers that have not been explored deeply in cases of frailty.

Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature

A. Picca, R. Beli, R. Calvani, et al.

Cells. 2020 Apr 15;9(4). pii: E973. doi: 10.3390/cells9040973.

Mitochondrial dysfunction and systemic inflammation are major factors in the development of sarcopenia, but the molecular determinants linking the two mechanisms are only partially understood. The study of extracellular vesicle (EV) trafficking may provide insights into this relationship.

Content of exercise programmes targeting older people with sarcopenia or frailty - findings from a UK survey

M.D. Witham, M. Chawner, S. Biase, et al.

J Frailty Sarcopenia Falls. 2020 Mar 1;5(1):17-23. doi: 10.22540/JFSF-05-017. eCollection 2020 Mar.

The aim was to establish whether existing exercise programmes offered to people with sarcopenia or frailty adhere to the current evidence base.

A potential urinary biomarker to determine frailty status among older adults

S. Jiang, L. Kang, M. Zhu, et al.

Arch Gerontol Geriatr. 2020 Feb 25;88:104038. doi: 10.1016/j.archger.2020.104038. [Epub ahead of print]

The aim was to evaluate whether urinary 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), a biomarker of RNA oxidative damage, was independently associated with frailty.

Plasma 25-hydroxyvitamin D level and the risk of frailty among Chinese community-based oldest-old: evidence from the CLHLS study

Q. Xiao, M. Wu, J. Cui, et al.

BMC Geriatr. 2020 Apr 6;20(1):126. doi: 10.1186/s12877-020-01523-w.

Vitamin D deficiency has been linked to the risk of frailty. However, there are limited methods for evaluations of the potential association of vitamin D with frailty in a longevous (80+) population. The aim of this study was to examine the association between plasma 25-hydroxyvitamin D [25(OH)D] levels and the risk of frailty among the Chinese community based oldest-old.

Association between sarcopenia and levels of growth hormone and insulin-like growth factor-1 in the elderly

A. Bian, Y. Ma, X. Zhou, et al.

BMC Musculoskelet Disord. 2020 Apr 7;21(1):214. doi: 10.1186/s12891-020-03236-y.

The purpose of the study is to understand the factors associated with sarcopenia and the role of growth hormone (GH) and insulin-like growth factor (IGF-1) in the occurrence of sarcopenia.

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