For Researchers

Apolipoprotein ε4 allele is associated with frailty syndrome: results from the hellenic longitudinal investigation of ageing and diet study

N. Mourtzi, E. Ntanasi, M. Yannakoulia, et al.

Age Ageing. 2019 Aug 23. pii: afz098. doi: 10.1093/ageing/afz098. [Epub ahead of print]

Apolipoprotein (APOE) ε4 allele has been associated with a number of age-related diseases but previous studies failed to identify any link with Frailty syndrome. The aim of the present study is to investigate the association between APOE ε4 allele and frailty syndrome.

Health Benefits of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Addition to Physical Exercise in Older Adults: A Systematic Review with Meta-Analysis

J. Courel-Ibáñez, T. Vetrovsky, K. Dadova, et al.

Nutrients. 2019;11(9)

Both regular exercise training and beta-hydroxy-beta-methylbutyrate (HMB) supplementation are shown as effective treatments to delay or reverse frailty and reduce cognitive impairment in older people. However, there is very little evidence on the true benefits of combining both strategies. The aim of this meta-analysis was to quantify the effects of exercise in addition to HMB supplementation, on physical and cognitive health in older adults.

The Biological Foundations of Sarcopenia: Established and Promising Markers

M. Casati, A.S. Costa, D. Capitanio, et al.

Front Med (Lausanne). 2019;6:184

The aim of this review is to suggest innovative and promising sarcopenia markers investigating the link between skeletal muscle and brain. Indeed, as a neurological origin of sarcopenia has been hypothesized, a new perspective on sarcopenia biomarkers may focus on the dysfunction of the neuromuscular junctions (NMJs).

If my muscle could talk: Myokines as a biomarker of frailty

H.J. Coelho-Junior, A. Picca, R. Calvani, et al.

Exp Gerontol. 2019 Aug 29:110715. doi: 10.1016/j.exger.2019.110715. [Epub ahead of print]

This review discusses the rationale to support the use of myokines as biomarkers of frailty in older adults.

Associations of fat-soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative

B. Kochlik, W. Stuetz, K. Pérès, et al.

J Cachexia Sarcopenia Muscle. 2019 Aug 21. doi: 10.1002/jcsm.12479. [Epub ahead of print]

A poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years.

Efficacy of Nutritional Interventions as Stand-Alone or Synergistic Treatments with Exercise for the Management of Sarcopenia

S. Damanti, D. Azzolino, C. Roncaglione, et al.

Nutrients. 2019;11(9)

At present, the only strategies for the management of sarcopenia are mainly based on nutritional and physical exercise interventions. The purpose of this review is to provide an overview on the role of proteins and other key nutrients, alone or in combination with physical exercise, on muscle parameters.