For Researchers

Muscle Mass, Muscle Strength, and Physical Performance in Older People: An Umbrella Review of Systematic Reviews and Meta-Analyses

E. Gielen, D. Beckwée, A. Delaere, et al.

Nutr Rev. 2020;nuaa011. doi:10.1093/nutrit/nuaa011.

The aim of this umbrella review was to provide an evidence-based overview of nutritional interventions targeting sarcopenia or at least 1 of the 3 sarcopenia criteria (ie, muscle mass, muscle strength, or physical performance) in persons aged ≥ 65 years.

Effects of a Multicomponent Exercise Program in Physical Function and Muscle Mass in Sarcopenic/Pre-Sarcopenic Adults

H. Makizako, Y. Nakai, K. Tomioka, et al.

J Clin Med. 2020 May 8;9(5):E1386. doi: 10.3390/jcm9051386.

This study aimed to assess the effects of a multicomponent exercise program on physical function and muscle mass in older adults with sarcopenia or pre-sarcopenia. Moreover, we aim to standardize the exercise program for easy incorporation in the daily life of community-dwelling older adults as a secondary outcome.

Urinary 8-oxo-7,8-dihydroguanosine as a potential biomarker of frailty for elderly patients with cardiovascular disease

Y.D. Liang, Q. Liu, M.H. Du, et al.

Free Radic Biol Med. 2020 Mar 23;152:248-254. doi: 10.1016/j.freeradbiomed.2020.03.011. [Epub ahead of print]

The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) in urine are two aging biomarkers that have not been explored deeply in cases of frailty.

Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature

A. Picca, R. Beli, R. Calvani, et al.

Cells. 2020 Apr 15;9(4). pii: E973. doi: 10.3390/cells9040973.

Mitochondrial dysfunction and systemic inflammation are major factors in the development of sarcopenia, but the molecular determinants linking the two mechanisms are only partially understood. The study of extracellular vesicle (EV) trafficking may provide insights into this relationship.

Content of exercise programmes targeting older people with sarcopenia or frailty - findings from a UK survey

M.D. Witham, M. Chawner, S. Biase, et al.

J Frailty Sarcopenia Falls. 2020 Mar 1;5(1):17-23. doi: 10.22540/JFSF-05-017. eCollection 2020 Mar.

The aim was to establish whether existing exercise programmes offered to people with sarcopenia or frailty adhere to the current evidence base.

A potential urinary biomarker to determine frailty status among older adults

S. Jiang, L. Kang, M. Zhu, et al.

Arch Gerontol Geriatr. 2020 Feb 25;88:104038. doi: 10.1016/j.archger.2020.104038. [Epub ahead of print]

The aim was to evaluate whether urinary 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), a biomarker of RNA oxidative damage, was independently associated with frailty.

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