For Healthcare Providers

Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study

M. Rabassa, R. Zamora-Ros, M. Urpi-Sarda, et al.

Am J Clin Nutr 2015;102:1534–42

Resveratrol may play a protective role against the frailty syndrome (FS) because of its antioxidant and anti-inflammatory properties. This study has prospectively evaluated the association between habitual dietary resveratrol exposure and the development of FS after 3-, 6-, and 9-years follow-up periods in a community-dwelling older population. This study has shown that higher habitual dietary resveratrol exposure was associated with lower risk of older community dwellers developing FS during the first 3 years of follow-up but not after longer follow-up periods.

Caloric restriction and aerobic exercise in sarcopenic and non-sarcopenic obese women: an observational and retrospective study

S. Barbat-Artigas, S. Garnier, S. Joffroy, et al.

J Cachexia Sarcopenia Muscle. 2016;7(3):284-9

The objective of this observational and retrospective study was to verify the effect of a mixed weight loss programme combining caloric restriction and exercise on body composition, and lipid-lipoprotein profile of obese women according to their sarcopenic status. Data obtained suggest that a short weight loss programme combining caloric restriction and aerobic exercise may significantly reduce fat mass and improve lipid-lipoprotein profile in obese women, independently of their sarcopenic status. Such programmes may have deleterious effects on lean mass in non-sarcopenic obese subjects, only.

Accelerometer-determined physical activity, muscle mass, and leg strength in community-dwelling older adults

Y.C. Foong, N. Chherawala, D. Aitken, et al.

J Cachexia Sarcopenia Muscle. 2016;7(3):275-83

The aim of this study was to describe the relationship between accelerometer-determined physical activity (PA), muscle mass, and lower-limb strength in community-dwelling older adults. Using accelerometer technology, both the amount and intensity of accelerometer-determined PA had an independent, dose-response relationship with lean mass percentage and lower limb strength, with the largest effect for vigorous activity. Time spent in sedentary activity was negatively associated with lean mass percentage, but was not associated with lower limb strength. The magnitude of the association between PA and lean mass percentage decreased with age.

Prevalence and risk factors of sarcopenia among adults living in nursing homes

H. E. Senior, T. R. Henwood, E. M. Beller, et al.

Maturitas. 2015; 82: 418–423

Sarcopenia is a progressive loss of skeletal muscle and muscle function, with significant health and disability consequences for older adults. This study was aimed to evaluate the prevalence and risk factors of sarcopenia among older residential aged care adults using the European Working Group on Sarcopenia in Older People (EWGSOP) criteria.

Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial

J.M. Bauer, S. Verlaan, I. Bautmans, et al.

J Am Med Dir Assoc .2015;16:740-747

This study was a multicenter, randomized, controlled, double-blind, 2 parallel-group trial among 380 sarcopenic primarily independent-living older adults. The aim of the study was to test the hypothesis that a specific oral nutritional supplement can result in improvements in measures of sarcopenia. Improvements in muscle mass and lower-extremity function were observed, suggesting that nutritional supplementation alone might benefit geriatric patients.

Nutritional, Physical, Cognitive and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial

T. P. Ng, L. Feng, M.S. Nyunt, et al.

Am J Med. 2015;128(11):1225-1236.e1

This study aimed to assess the reversibility of frailty in 246 community-living prefrail and frail older people in Singapore (mean age: 70 years). Participants were randomly assigned to 5 different 6-month interventions: nutritional supplementation, physical training, cognitive training, combination treatment and usual care control. Frailty score, body mass index, knee extension strength, gait speed, energy/vitality, physical activity levels and secondary outcomes (activities of daily living dependency, hospitalization and falls) were assessed at 0, 3, 6 and 12 months. Frailty score and status over 12 months were reduced in all groups, but the reduction rates were significantly higher in the intervention groups compared with the usual care control group, with the combination intervention group showing the highest odds (OR 5.00). Beneficial effects persisted at 12 months.

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