To date, no healthcare programs or pharmacological treatments are available for frail older people. This is largely due to the current lack of a precise, universal definition of frailty, which in turn is linked to the multidimensional nature of the condition. Moreover, the existing gaps in knowledge are reflected by the absence of effective interventions (either pharmacological or behavioral) against frailty. Such a barrier may be overcome by developing and validating a robust conceptual framework of frailty to achieve a practical operationalization of the condition. This conceptualization should also improve the definition of the pathophysiological and clinical foundations of frailty to assist in the design and implementation of specific therapeutic interventions aimed at restoring robustness or delaying the onset of adverse events (in particular, disability).